TCL-1B2 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the TCL-1B2 protein, a member of the TCL1 family, which is known for its involvement in cellular signaling pathways that regulate growth, proliferation, and survival. TCL-1B2 is thought to function by interacting with key signaling molecules, particularly those involved in the PI3K/AKT pathway, a crucial pathway that governs cell metabolism, survival, and growth in response to extracellular signals. By inhibiting TCL-1B2, these compounds can disrupt its interactions with other proteins, leading to alterations in the PI3K pathway and other interconnected signaling networks. This disruption has a significant impact on cellular processes such as the cell cycle, metabolism, and signal transduction.
The study of TCL-1B2 inhibitors provides valuable insights into the role of TCL-1B2 in maintaining cellular homeostasis and regulating intracellular communication. Researchers use these inhibitors to examine how blocking TCL-1B2 affects key signaling events that contribute to cellular responses like growth and differentiation. Through the inhibition of TCL-1B2, scientists can also explore the unique role this protein plays within the broader TCL1 protein family, offering a more refined understanding of how specific members of this family contribute to signaling regulation. These inhibitors are important tools for uncovering the molecular dynamics of the PI3K/AKT pathway and its role in regulating diverse cellular functions, allowing for a better understanding of how cells balance growth signals and maintain metabolic stability. In essence, TCL-1B2 inhibitors are instrumental in dissecting the complexity of intracellular signaling networks and the protein interactions that sustain cellular function and structure.
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产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | ¥745.00 ¥2471.00 ¥4705.00 | 97 | |
沃特曼宁是一种甾体代谢物,是磷酸肌酸 3- 激酶(PI3K)的强效抑制剂,可能会通过影响 PI3K/AKT 信号通路来降低 TCL1B 的活性。 | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | ¥1365.00 ¥4423.00 | 148 | |
LY294002 是一种合成分子,可抑制 PI3K,从而降低 AKT 磷酸化,并可能减少 TCL1B 介导的信号传导。 | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | ¥699.00 ¥1749.00 ¥3610.00 | 233 | |
雷帕霉素是一种免疫抑制剂,可抑制 PI3K/AKT 通路的下游靶点 mTOR,从而可能影响与 TCL1B 相关的细胞增殖。 | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | ¥733.00 ¥3012.00 | 257 | |
SP600125 是一种 c-Jun N 端激酶(JNK)的蒽吡唑啉酮抑制剂,可通过改变 AP-1 转录因子相关的信号转导来改变 TCL1B 的活性。 | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | ¥993.00 ¥3858.00 | 284 | |
SB203580 是一种吡啶基咪唑衍生物,可选择性抑制 p38 MAPK,从而调节 TCL1B 发挥作用的细胞环境。 | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | ¥3554.00 | ||
Palbociclib 是细胞周期蛋白依赖性激酶 4/6 (CDK4/6) 的选择性抑制剂,可能会影响细胞周期的进展,从而间接影响 TCL1B 的活性。 | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | ¥440.00 ¥1015.00 | 212 | |
PD98059 是一种抑制 MEK 的合成化合物,可能会导致 ERK 激活减少,并间接影响 TCL1B 信号通路。 | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | ¥530.00 ¥1636.00 | 51 | |
达沙替尼是一种多激酶抑制剂,对SRC家族激酶具有活性,可能会影响与TCL1B通路交叉的信号级联。 | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | ¥1038.00 ¥2516.00 | 30 | |
PP2 是 Src 家族酪氨酸激酶的选择性抑制剂,可改变影响 TCL1B 相关过程的下游信号。 | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | ¥632.00 ¥2933.00 ¥4693.00 | 129 | |
索拉非尼(Sorafenib)是一种针对多种受体的激酶抑制剂,可能会影响与 TCL1B 相关的信号通路。 |