Peg10 Inhibitors refer to a diverse class of chemical compounds designed to target and modulate the activity of the PEG10 gene, primarily by interfering with its expression or function. PEG10, which stands for Paternally Expressed Gene 10, is a unique imprinted gene in mammals, implicated in various cellular processes, including cell proliferation, apoptosis, and cancer development. Inhibitors within this class act as valuable tools for researchers and scientists to investigate the intricate mechanisms through which PEG10 influences these processes. These compounds exhibit diverse chemical structures and mechanisms of action, enabling a comprehensive exploration of PEG10's roles in cellular biology.
The mechanisms by which Peg10 Inhibitors function can vary widely. Some compounds focus on epigenetic regulation, impacting PEG10 gene expression by targeting DNA methylation or histone modifications within its regulatory regions. Others may affect post-transcriptional processing, mRNA stability, or translation of PEG10 transcripts. Additionally, Peg10 Inhibitors can potentially interfere with the interactions between PEG10 and its downstream targets, inhibiting specific cellular pathways or signaling cascades associated with PEG10 function. By providing a suite of chemical tools to manipulate PEG10, this class of inhibitors empowers researchers to unravel the complex web of molecular events associated with PEG10's role in normal cellular physiology and disease states. Understanding the mechanisms and consequences of PEG10 inhibition can pave the way for new insights into the fundamental biology of this gene and its potential implications in various biological contexts.
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| Produkt | CAS # | Katalog # | Menge | Preis | Referenzen | Bewertung |
|---|---|---|---|---|---|---|
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | ¥1455.00 ¥3204.00 ¥11327.00 | 3 | |
Zebularin ist ein DNA-Methyltransferase-Inhibitor, der die Methylierung der PEG10-Promotorregion verhindert, was zu einer reduzierten PEG10-Genexpression führt. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | ¥2459.00 ¥3633.00 ¥4806.00 | 7 | |
Dieser Inhibitor, der auch als Decitabin bekannt ist, wirkt ähnlich wie Zebularin, indem er DNA-Methyltransferasen hemmt und den PEG10-Promotor demethyliert. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | ¥1478.00 ¥5810.00 | 2 | |
RG108 ist ein niedermolekularer Inhibitor von DNA-Methyltransferasen, einschließlich solcher, die an der PEG10-Promotor-Methylierung beteiligt sind. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | ¥722.00 ¥2065.00 | 11 | |
Scriptaid ist ein Histon-Deacetylase (HDAC)-Inhibitor, der die epigenetische Regulation moduliert und damit indirekt die PEG10-Expression beeinflusst. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | ¥3159.00 | 4 | |
Dieses Cytidin-Analogon wird in die DNA eingebaut und hemmt DNA-Methyltransferasen, was die Methylierung des PEG10-Promotors beeinflusst. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | ¥982.00 | 9 | |
Valproinsäure ist ein HDAC-Inhibitor, der die PEG10-Expression durch Veränderung der Histon-Acetylierungsmuster beeinflussen kann. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | ¥3554.00 | ||
UNC0638 ist ein G9a-Histon-Methyltransferase-Inhibitor, der die PEG10-Expression indirekt durch Veränderungen der Histon-Methylierung beeinflusst. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | ¥745.00 | ||
EPZ-6438 ist ein EZH2-Histon-Methyltransferase-Inhibitor, der die PEG10-Expression durch Beeinflussung der Histon-Methylierungsmuster moduliert. | ||||||