T cell leukemia homeobox (TLX) 抑制因子

T cell leukemia homeobox (TLX) signaling is a critical regulatory pathway predominantly studied in the context of neural development and brain function. TLX, a member of the nuclear receptor family of transcription factors, plays a pivotal role in regulating the balance between neural stem cell proliferation and differentiation. In the brain, TLX is known to maintain neural stem cells in an undifferentiated and proliferative state, influencing neurogenesis during development and in the adult brain. It achieves this by regulating the expression of target genes involved in cell cycle control, apoptosis, and stem cell maintenance.

T cell leukemia homeobox (TLX) aim to modulate these processes by interfering with the ability of TLX to bind DNA or by influencing its interaction with co-regulatory proteins. The development of TLX inhibitors is driven by the need to understand the molecular mechanisms underlying neural development and the potential dysregulation of these pathways. This class of inhibitors targets the functional domains of TLX, especially the DNA-binding domain or the ligand-binding domain, to its interaction with target genes.