Panobinostat 的分子结构, CAS编号: 404950-80-7
Panobinostat (CAS 404950-80-7)
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备用名:
Panobinostat is also known as LBH-589.
应用:
Panobinostat 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，据报道可抑制人类多发性骨髓瘤细胞系。
CAS号码:
404950-80-7
纯度:
≥98%
分子量:
349.43
分子式:
C21H23N3O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Panobinostat (LBH589) 是一种HDAC (组蛋白去乙酰化酶) 抑制剂，对多发性骨髓瘤等多种疾病具有研究价值。据报道，Panobinostat 可抑制几种人多发性骨髓瘤细胞系，IC50≥20nM。据报道，Panobinostat还可诱导DNA损伤反应基因的表达，并诱导Ph-急性淋巴细胞白血病细胞的凋亡。除了脊髓性肌萎缩和HIV治疗外，Panobinostat在几种不同形式的癌症中也有潜在的应用。
Panobinostat (CAS 404950-80-7) 参考文献
- 蛋白酶体抑制剂硼替佐米诱导的聚集体与管蛋白去乙酰化酶（TDAC）抑制剂LBH589诱导的α-管蛋白超乙酰化在骨髓瘤细胞中具有协同作用。 | Catley, L., et al. 2006. Blood. 108: 3441-9. PMID: 16728695
- 组蛋白去乙酰化酶抑制剂会消耗人类急性白血病细胞中的泽斯特2增强子和相关的多聚酶抑制复合体2蛋白。 | Fiskus, W., et al. 2006. Mol Cancer Ther. 5: 3096-104. PMID: 17172412
- 新型组蛋白去乙酰化酶抑制剂LBH589可诱导Ph-急性淋巴细胞白血病细胞中DNA损伤应答基因的表达和细胞凋亡。 | Scuto, A., et al. 2008. Blood. 111: 5093-100. PMID: 18349321
- 成人 T 细胞白血病/淋巴瘤中 Zeste 同源体 2 的过度表达与组蛋白 H3 上赖氨酸 27 的三甲基化是表观遗传学治疗的靶点。 | Sasaki, D., et al. 2011. Haematologica. 96: 712-9. PMID: 21228036
- 2018年的帕诺比诺司他与多发性骨髓瘤。 | Yee, AJ. and Raje, NS. 2018. Oncologist. 23: 516-517. PMID: 29445026
- 帕诺比诺司他（LBH589）通过上调乳腺癌中APCL的表达抑制Wnt/β-catenin信号通路。 | Qin, G., et al. 2019. Cell Signal. 59: 62-75. PMID: 30880222
- Panobinostat 可穿透血脑屏障，并在小鼠模型中达到有效的脑浓度。 | Homan, MJ., et al. 2021. Cancer Chemother Pharmacol. 88: 555-562. PMID: 34115161
- 帕诺比诺司他（Panobinostat）通过增加前列腺癌组蛋白乙酰化逆转HepaCAM基因表达并抑制其增殖。 | Chen, E., et al. 2022. Gene. 808: 145977. PMID: 34592353
- 帕诺比诺司他（Panobinostat）通过改变卵巢癌中同源重组修复和免疫转录本的表达增强奥拉帕利的疗效。 | Wilson, AJ., et al. 2022. Neoplasia. 24: 63-75. PMID: 34933276
- 帕诺比诺司他（Panobinostat）可增强软组织肉瘤中 NK 细胞的细胞毒性。 | Lu, X., et al. 2022. Clin Exp Immunol. 209: 127-139. PMID: 35867577
- 帕诺比诺司他（LBH589）可提高t(4;11)急性淋巴细胞白血病成人异种模型的存活率，但与MTX和6MP联用会产生拮抗作用。 | Moreno, DA., et al. 2022. Med Oncol. 39: 216. PMID: 36175721
- 帕诺比诺司他（Panobinostat）通过Vps34介导的外泌体途径抑制乳腺癌的进展。 | Wang, X. and Yin, X. 2023. Hum Cell. 36: 366-376. PMID: 36329365
- 帕诺比诺司他能协同增强卵巢癌细胞中破坏微管稳定药物的细胞毒性 | Ovejero-Sánchez, M., et al. 2022. Int J Mol Sci. 23: PMID: 36361809
- 帕诺比诺司他（Panobinostat）与美法兰（Melphalan）联合治疗多发性骨髓瘤患者。 | Gkotzamanidou, M., et al. 2022. Int J Mol Sci. 23: PMID: 36555311
- 组蛋白去乙酰化酶抑制剂帕诺比诺司他（Panobinostat）可提高肿瘤溶解性单纯疱疹病毒结合 PD-1/PD-L1 阻断剂在胶质瘤和鳞状细胞癌模型中的疗效 | Wu, Y., et al. 2022. Viruses. 14: PMID: 36560800
抑制剂：
1200013P24Rik, 4632411B12Rik, 4930502E18Rik, 4930557A04Rik, 5430421N21Rik, 6430550D23Rik, 9430015G10Rik9, A26C1B, A530032D15Rik, A630023A22Rik, AA416372, AB056442, Acatin, AGAP3, AKAP 1, ANKRD11, ANKRD20A5, ANKRD26, ASF1B, ASH2L, ASXL1, ASXL3, BAF250a, BAF57, BAF60a, BAGE4, BAHD1, BCoR, Bdf1, Blood Group H2, BORIS, BPTF, BRMS1L, BRWD1, Btnl1, c-Maf, C14orf43, cbp146, CDY2, CECR2, Chr-B, CHRAC17, Codanin-1, CPA6, CREST, CSN1, Dmap1, DNHD1, DNHD2, DPY-30, Dpy30, DUX3, DYDC2, Dynlt1d, Elongin C, Eso-1, EZI, FAM120AOS, FcRH5, FOXF2, FRYL, GAGE, GAGE12G, GAGE13, GAGE4, GATAD (GATA zinc finger domain containing), GATAD2A, Gm15070, Gm806, GSC, H2-A, H2-M10.1, H2afb2, H2al3, H2BFWT, H3.Y histone 1, H3.Y Histone 2, H60, HAT1, Hat2, Hbb-y, hCAP-D3, hCG_1982709, HDA1, HDA2, HDA4, HDA5, HDA6, HDA7, HDAC, HDAC1, HDAC11, HDAC2, HDAC3, HDAC6, HESL, Hils1, HiNF-P, Histone B, Histone cluster 1 H1C, Histone cluster 1 H1D, Histone cluster 1 H1E, Histone cluster 1 H2A, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AE, Histone cluster 1 H2AG, Histone cluster 1 H2AL, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3B, Histone cluster 1 H3C, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H3I, Histone cluster 1 H3J, Histone cluster 1 H4, Histone cluster 1 H4G, Histone cluster 1 H4H, Histone cluster 1 H4K, Histone cluster 2 H2AA3, Histone cluster 2 H2AB, Histone cluster 2 H2AC, Histone cluster 2 H3A, Histone cluster 2 H3C, Histone cluster 2 H3C1, Histone cluster 2 H3C2, Histone cluster 2 H4, Histone H10, Histone H2A.Bbd, Histone H2A.F, Histone H2A.V, Histone H2A.X, Histone H2B.S, Histone H3, Histone H4, Histone Z, HLF, HoxA4, Ikaros, ING3, INO80D, Integrin, Integrin αV, Intelectin-b, INTS10, INTS8, INTS9, JAZF1, JMJD1A, kismet, L3MBTL2, Lacrein, LDOC1L, LIN-35, LIN-53, LOC100040657, LOC150383_2210021J22Rik, LOC340094, LOC388282, LOC646012, LOC665622, LOC729458, Lyl-1, lysine, Mael, MAGE-A11, MAGE-A2, MAGE-A9, MAGE-A9B, MAGE-B1, MAGE-B18, MAGE-B3, MAGE-B5, MAGE-E2, MAGE-F1, MAGE-G2, mage-k1, Mammaglobin A, Mi2-α, MIER1, MIER3, MLLT (Mixed Lineage Leukemia Translocated), Morc1, Morc3, MORF, MORF4L2, MRG15, MRGBP, mSin3A9, Msx-3, Mxi 1, NAP1L2, NAP1L5, NBPF24, NIF-1, NKAP, Npcd, Nup62-il4i1, NWD1, NY-REN-34, Obox3, Obox5, OCIAD1, Olr542, Olr556, Olr557, Olr577, Olr601, Olr610, Olr611, Olr614, Olr619, Olr634, Olr636, Olr639, Olr697, OTTMUSG00000016789, OTTMUSG00000016790, OTTMUSG00000016887, OTTMUSG00000018481, OTTMUSG00000018888, p130, p130 Cas, p150, p400, PAGE-2, pan-Acetyl, PATE2, PCDHB13, PCDHGA5, PCDHGA6, PEG3, PGs2_5730494M16Rik, PHF12, PHF2, PHF21A, PHF6, PI-9, Pi15, PLAC4, PRAMEF10, PRAMEF14, PRAMEF17, PRAMEF3, PRAMEF9, PRDM10, PRDM15, PRDM4, PRDM8, PWWP2B, RASSF1C, RBBP1, RBM25, RBM35B, RFXAP, RhD, RIZ, RP2, RP23-480B19.10, Rpd3, SAMD4B, SAP 130, SAP 25_Sap25, SAP 30L, SDS3, SETD5, SFMBT2, Siglec-5, SIM2, Sin3, Slfn11, SMARCD2, SMYD2, SNF2L, Snf5, SNURF, SPIN2, SPNS2, SPRN, SRRM5, STAMP2, STOX2, Subh2bv, T cell leukemia homeobox (TLX), TADA3L, TAF II p68, TAF II p70, TFPT, TIGD2, TIGD3, TNRC18, TOX3, Trav12d-3, TRRAP, TSPY9, TSSC4, TTC1, Tup1, UBN-1, USP49, V1RH18, VPS72, VSTM2A, WDR79, WIZ, WT1, YDJC, YEATS2, ZBP-89, ZBTB (Zinc finger BTB domain containing), ZBTB1, ZCWPW1, ZCWPW2, ZFP383, ZFP57, ZFP605, Zfp78, ZFP811, ZFP819, ZFP839, Zfp868, Zfp93, Zfp931, ZFP936, ZFP963, ZFP97, ZFY1, ZFY2, ZMYM6NB, ZMYND12, ZNF160, ZNF165, ZNF224, ZNF274, ZNF304, ZNF385A, ZNF536, ZNF57, ZNF649, ZNF711, ZNF740, 和 ZNHIT1.激活剂：
2900008C10Rik, 4930557A04Rik, ALKBH7, ASXL2, ATF-7IP, ATXN7L2, BAF53B, BAF60a, BAFL, BAZ2A, BRD3, BRD8, BRWD3, BTF3, C230099D08Rik, CBX7, CD38, CENP-A, CHD2, CHRAC15, CLAMP, CMTM2a, CSS2, D2Bwg1423e, DCHS1, DDO, DNAH14, DPF1, EAF1, EFO2, EG236663, EG385328, EG546205, EID-1, Erg, FAM188B2, FIV p27, FOXP3, GAGE3, GAGE7B, GAS41, H1T2, H2AL2, H2al2y, H2BFA, HDA4, HDA5, HHV-4 EBNA-2, HHV-4 LMP-1, HHV-4 ZEBRA, Histone cluster 1 H1B, Histone cluster 1 H2A, Histone cluster 1 H2AA2, Histone cluster 1 H2AC, Histone cluster 1 H2AE, Histone cluster 1 H2AG, Histone cluster 1 H2AK, Histone cluster 1 H2AM, Histone cluster 1 H2AN, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BF, Histone cluster 1 H2BH, Histone cluster 1 H2BP, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H4, Histone cluster 1 H4F, Histone cluster 1 H4I, Histone cluster 1 H4L, Histone cluster 1 H4M, Histone cluster 2 H2AA1, Histone cluster 2 H3B, Histone cluster 2 H3C, Histone cluster 2 H3C2, Histone cluster 2 H4, Histone cluster 2 H4B, Histone cluster 3 H2ba, Histone cluster 4 H4, Histone H1B, Histone H1X, Histone H2A.V, Histone H2B, HIV gp24, HIV-1 p17, HIV-1 p55, HIV-1 Tat, HMG I, HMG-14, HMG-4, HoxD9, HPF1, JMJD2D, KIAA1688, KIAA1704, KIAA2026_9930021J03Rik, L3MBTL, LAGE-2A, Lamin A, LANPL, LDOC1L, LHFP, LIN-54, LOC100039210, LOC100041215, LOC128977, LOC646522, LOC646719, LOC729454, MAGE-A4, MAGE-A6, MAGE-G2, MAML3, MBTD1, Menin, MPHOSPH8, MRGBP, mSin3B, Mxi 1, MYSM1, NAP1L4, NFATc2IP, NY-ESO-1, Peregrin, periphilin 1, PHF20, PRAME like-3, PRAME like-6, PRAME like-7, PRAMEF12, PRAMEF14, PRAMEF16, PRAMEF17, PRAMEF18, R3HCC1, RASSF1, RASSF1F, RBA-1, RbAp46, RCOR2, rotavirus C vp4, SAP 18, SCML2, Sec24, SETD6, Siglec-9, SMARCD2, SPT16, SUV420H2, SWI/SNF-B, Swi3, SYT, TCFL5, TMED3, TMED5, Trimethyl Histone H3, u4/u6 snRNP, WSTF, XAGE-1, ZKSCAN4, ZNF295, ZNF33A, ZNF33B, ZNF345, ZNF396, ZNF469, ZNF498, ZNF553, ZNF597, ZNF671, ZNF806, 和 ZNF828.订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
Panobinostat, 10 mg | sc-208148 | 10 mg | RMB2211.00 |