CHD (chromodomain helicase) 抑制因子

The CHD (chromodomain helicase DNA-binding) family of proteins are ATP-dependent chromatin remodelers that play a crucial role in the regulation of gene expression. These proteins possess a chromodomain, enabling them to specifically recognize and bind to methylated histone tails, a key feature in the epigenetic control of gene expression. This remodeling activity is essential for various cellular processes, including transcriptional regulation, DNA repair, and chromosome organization. CHD proteins can act as both activators and repressors of transcription, depending on the context and specific interactions with other regulatory molecules. Their function and signaling pathways are tightly regulated, and dysregulation of CHD proteins is associated with developmental disorders, neurological disorders, and cancers.

Targeting CHD (chromodomain helicase DNA-binding) proteins with small molecules for disruption or inhibition provides a valuable tool for understanding their mechanistic roles in cellular processes. For instance, inhibiting the ATPase activity of CHD proteins can reveal their role in chromatin remodeling and its impact on transcriptional regulation. Additionally, using small molecule inhibitors to block the interaction between CHD proteins and methylated histones can help in determining how these proteins recognize and bind to specific chromatin marks.