BIX01294 hydrochloride 的分子结构, CAS编号: 1392399-03-9
BIX01294 hydrochloride (CAS 1392399-03-9)
备用名:
2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride
应用:
BIX01294 hydrochloride 是一种选择性组蛋白甲基转移酶（HMTase）抑制剂。
CAS号码:
1392399-03-9
纯度:
≥98%
分子量:
600.00
分子式:
C28H38N6O2•3HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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描述
技术信息
安全信息
安全技术说明书和分析证明书
BIX01294盐酸盐抑制G9a。组蛋白甲基转移酶（HMTase）G9a可以单甲基化或二甲基化组蛋白3（H3）上的赖氨酸9，促进早期胚胎发生、基因组印记和淋巴细胞发育。BIX01294盐酸盐是G9a HMTase的选择性抑制剂（IC50=1.7 µM）。它对HMTase G9a样蛋白（GLP；IC50=38 µM）的抑制作用较弱，对其他已知的HMTases没有影响。BIX01294盐酸盐已与钙通道激活剂BayK8644联合使用，以促进体细胞在体外产生诱导多能干细胞。BIX01294盐酸盐是一种HDAC抑制剂。
BIX01294 hydrochloride (CAS 1392399-03-9) 参考文献
- 一个独特的毒性基因在恶性疟原虫的免疫逃避中占据主要地位 | Ukaegbu, UE., et al. 2015. PLoS Genet. 11: e1005234. PMID: 25993442
- 高通量筛选产生了几种重复相关非 AUG 翻译的小分子抑制剂。 | Green, KM., et al. 2019. J Biol Chem. 294: 18624-18638. PMID: 31649034
- 表观遗传药物库的筛选发现了 4-((羟基氨基)羰基)-N-(2-羟乙基)-N-苯基苯乙酰胺，它通过抑制酪氨酸酶的活性来减少黑色素的合成，而与表观遗传机制无关。 | Song, H., et al. 2020. Int J Mol Sci. 21: PMID: 32605171
- 用于药物发现的机器学习策略可识别抗血吸虫小分子。 | Zorn, KM., et al. 2021. ACS Infect Dis. 7: 406-420. PMID: 33434015
- 用于脑膜瘤潜在治疗的表观遗传化合物的高通量机制筛选 | Tatman, PD., et al. 2021. J Clin Med. 10: PMID: 34300316
- 南昌霉素调控 FYN, PTK2 和 MAPK1/3 以控制人肝星状细胞的纤维化活性 | Li, W., et al. 2022. Elife. 11: PMID: 35617485
抑制剂：
2610110G12Rik, 2810474O19Rik, ACF, ACTR6, ALKBH2, ASCL5, BAF53B, BAZ1A, BAZ2B, BC066135, BCDIN3, BCORL1, C1orf156, C3orf14, C9orf41, CDYL2, CHD (chromodomain helicase), CHD2, CHD5, CHD7, CHD9, Cypt3, Dnmt2, Dnmt3a, DPPA2, EG333452, EG625464, EHM2, Elongin C, EPC1, ESCO1, FBXW26, Fibrillarin-like 1, FOG, FOXB2, FOXD4, FOXD4L2, FOXD4L4, FOXD4L6, FOXR2, G9a, GAGE2A, GATA-6, Gm98, GPR85, H3-K9-HMTase, H3.Y Histone 2, HAT1, hCG_1982709, HDAC, HIRA, Histone cluster 1 H1T, Histone cluster 1 H2AA4, Histone cluster 1 H3D, Histone cluster 1 H3H, Histone cluster 1 H4F, Histone cluster 1 H4G, Histone cluster 1 H4J, Histone cluster 3 H3, Histone H1, Histone H2BM, Histone H3.3B, HoxA2, HoxA7, hyccin, INO80E, KMT5 (lysine methyltransferase), L3MBTL4, LOC145783, LRRC29, MacroH2A2, Mael, Med17, METT11D1, METTL12, METTL22, METTL23, METTL25, METTL2A, METTL2B, MGC50559_4833442J19Rik, Monomethyl Histone H4, Morc1, MSL3L2, NAP5, NSUN1, PA1, Paired Box (PAX), Pax-6, PCDH11Y, PHF13, PHF16, PHF20, PHF20L1, PHF23, PIWIL4, PLAG1, Plectin, PRDM9, Protamine 3, PSRC2, PWWP2A, RCOR2, RGS6, RNMTL1, SAP 30BP, SET7/9, SETD4, SFMBT1, SFMBT2, SMYD4, Sox-9, Sp9, SUV39H1, TMEM98, TRMU, TSPYL6, VSTM2A, ZBTB37, ZBTB43, ZC3H13, ZDBF2, ZNF131, ZNF206, ZNF267, ZNF276, ZNF322A, ZNF597, ZNF607, ZNF642, 和 ZNF644.激活剂：
β1-Syntrophin, 1700011H14Rik, ADA3, ALKBH5, ASH2L, ASXL1, ASXL2, ASXL3, BRD9, BRMS1L, BRUNOL4, BTBD14A, CMV pp65, Cypt2, Cypt4, D530049N12Rik, DPPA4, DXBay18, E(z), E130012A19Rik, E130309D02Rik, E130311K13Rik, ECOP, EG245651, EG384244, EZHIP, FTSJ3, Glrp-1, H2BFWT, Histone cluster 1 H2AD, Histone cluster 1 H2AJ, Histone cluster 1 H2AL, Histone cluster 1 H2BB, Histone cluster 1 H2BE, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H3C, Histone cluster 1 H3J, Histone cluster 1 H4F, Histone cluster 1 H4L, Histone cluster 2 H2AA3, Histone cluster 2 H2BE, Histone cluster 2 H3A, Histone cluster 2 H4A, Histone H3.3B, Histone H4, HKDC1, hnRNP H′/hnRNP H2, HP1, JMJD4, kismet, L3MBTL3, LANPL, LOC644070, LURAP1L, MacroH2A1, MLL4, Morc3, MSL3L1, MYSM1, N-CoR, NAP1L1, Paf1, PCGF6, POLR2D, PRDM14, RBM26, RCBTB2, RNF20, RRP8, SAP 30L, SCML1, Set2, Snf5, Sox19, SPT6, SUV39H1, SUV420H1, TAF II p68, TAF9A, TBL1Y, TCEAL1, TCF-19, VPS72, ZFP57, ZNF142, ZNF583, ZNF585A, ZNF671, 和 ZSWIM6.订购信息
| 产品名称 | 产品编号 | 规格 | 价格 | 数量 | 收藏夹 | |
BIX01294 hydrochloride, 1 mg | sc-293525 | 1 mg | RMB406.00 | |||
BIX01294 hydrochloride, 5 mg | sc-293525A | 5 mg | RMB1241.00 | |||
BIX01294 hydrochloride, 25 mg | sc-293525B | 25 mg | RMB4513.00 |