Date published: 2026-11-7

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MDM2 Antibody (HDM2-323) - Western Blotting - Image 54445
MDM2 抗体 (HDM2-323): sc-56154. U-2 OS 全细胞裂解液中 MDM2 表达的 Western 印迹分析.
MDM2 Antibody (HDM2-323) - Western Blotting - Image 54445
MDM2 抗体 (HDM2-323): sc-56154. U-2 OS 全细胞裂解液中 MDM2 表达的 Western 印迹分析.
MDM2 Antibody (HDM2-323) - Western Blotting - Image 50256
MDM2 抗体 (HDM2-323): sc-56154. 对 Saos-2 全细胞裂解液中 MDM2 的表达进行 Western 印迹分析.
MDM2 抗体 (HDM2-323): sc-56154. U-2 OS 全细胞裂解液中 MDM2 表达的 Western 印迹分析.

MDM2 抗体 (HDM2-323): sc-56154

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说明书
  • MDM2 抗体 HDM2-323 是小鼠单克隆 IgG2a, 在33篇文献中引用，提供 100 µg/ml
  • 免疫human物种的MDM2的氨基酸389-402
  • 推荐用于 mouse, rat 和 human 来源的MDM2 WB 和 IP检测
  • 看 MDM2 (SMP14): sc-965，可查看有标记的 MDM2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是MDM2 Antibody (HDM2-323) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与MDM2 Antibody (HDM2-323) 打包提供（请参阅下面的订购信息）。
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描述
基因信息
说明书与实验方案
研究信息

関連項目

MDM2抗体（HDM2-323）是一种IgG2a小鼠单克隆MDM2抗体，可通过WB和IP检测小鼠、大鼠和人的MDM2。MDM2抗体（HDM2-323）为非偶联的抗MDM2抗体形式。p53是目前为止在人类癌症中最常见的突变基因。p53的表达通过阻止细胞从G1期进入S期来抑制细胞生长。最重要的是，p53的功能是在细胞暴露于DNA损伤因子后，使细胞在细胞周期的G1期停滞。MDM2（鼠双微体2）蛋白最初是在鼠转化系统中被鉴定为致癌基因。MDM2的功能是与p53结合，并阻断p53介导的共转染报告基因构建的反式激活。MDM2基因在保留野生型p53的人类肉瘤中的扩增比例很高，而过表达MDM2的肿瘤细胞可以耐受高水平的p53表达。这些发现表明，MDM2的过表达至少是p53功能在肿瘤发生过程中被废除的一种机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

含汞：所有HRP偶联物（包括组合装）均含有硫柳汞，这是一种汞化合物。请勿丢弃在垃圾中。应按照当地、州和联邦法规，将其作为危险化学品废弃物进行处置。

下载硫柳汞安全数据表（SDS）

MDM2 抗体 (HDM2-323) 参考文献:

  1. 生长信号和癌症中的 Mdm2。  |  Levav-Cohen, Y., et al. 2005. Growth Factors. 23: 183-92. PMID: 16243710
  2. Mdm2和MdmX合作调节p53。  |  Wang, X. and Jiang, X. 2012. FEBS Lett. 586: 1390-6. PMID: 22673503
  3. DNA损伤后MDM2稳定性的调节。  |  Li, J. and Kurokawa, M. 2015. J Cell Physiol. 230: 2318-27. PMID: 25808808
  4. 食管癌中MDM2基因扩增。  |  Michalk, M., et al. 2016. Oncol Rep. 35: 2223-7. PMID: 26796597
  5. NORE1A 通过 β-TrCP 调节 MDM2  |  Schmidt, ML., et al. 2016. Cancers (Basel). 8: PMID: 27023610
  6. MDM2寡聚体：基因组守护者的拮抗剂。  |  Leslie, PL. and Zhang, Y. 2016. Oncogene. 35: 6157-6165. PMID: 27041565
  7. MDM2通过诱导EMT（独立于p53）增加癌细胞的耐药性。  |  Sun, W. and Tang, L. 2016. Curr Med Chem. 23: 4529-4539. PMID: 27686656
  8. 二氢嘧啶衍生物作为MDM2抑制剂。  |  Mehri, A., et al. 2024. Chem Biol Drug Des. 103: e14399. PMID: 38011915
  9. 褪黑素通过MDM2介导的ACSL4泛素化改善中风。  |  Ji, Q., et al. 2024. Aging (Albany NY). 16: 1925-1937. PMID: 38289595
  10. MDM2功能。  |  Lozano, G. and Montes de Oca Luna, R. 1998. Biochim Biophys Acta. 1377: M55-9. PMID: 9606977

订购信息

产品名称产品编号规格价格数量收藏夹

MDM2 抗体 (HDM2-323)

sc-56154
100 µg/ml
CNY2422.00

MDM2 (HDM2-323): m-IgG Fc BP-HRP 套装

sc-539031
100 µg Ab; 10 µg BP
CNY2715.00

MDM2 (HDM2-323): m-IgG2a BP-HRP 套装

sc-546661
100 µg Ab; 10 µg BP
CNY2715.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 3
Date published: 2017-02-14
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Rated 5 out of 5 by timke0918 from Great antibodyVery nice results from hippocampus tissue by WB analysis, in 1:500 dilution.
Date published: 2018-05-24
Rated 5 out of 5 by Cweed from Good for Western blotCapable of providing a clear and specific signal at the expected molecular weight. It also reacts well with mouse, rat, and human samples. This product has been used to publish several times.
Date published: 2017-02-07
Rated 5 out of 5 by DaveTheScienceGuy from Works greatThis antibody works great for both human and mouse cell lysate. WB showed a clean band with little background (1:1000).
Date published: 2016-11-15
Rated 4 out of 5 by Xing_Huang from Worked well in WBWorked well in WB
Date published: 2015-11-17
Rated 5 out of 5 by LM from Clean blot with single strong band at expectedClean blot with single strong band at expected size in Saos-2 whole cell lysate. -SCBT QC
Date published: 2015-03-22
Rated 4 out of 5 by MS from Nice publishable data on Western blot onNice publishable data on Western blot on human HEK293 cells, and LNCaP cells (human prostate carcinoma). -SCBT Publication Review
Date published: 2015-03-16
Rated 4 out of 5 by NZ from Performs well in WesternPerforms well in Western, good signal with U-2 OS whole cell lysate. -SCBT QC
Date published: 2015-03-06
Rated 5 out of 5 by LF from Publishable Western blot results using human BCPublishable Western blot results using human BC-PAP, Hth-74, various thyroid cancer cells. -SCBT Publication Review
Date published: 2015-01-13
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MDM2抗体 (HDM2-323) is rated 4.7 out of 5 by 9.
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