Date published: 2025-9-17

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Anticorps SPA-1 (C-1): sc-137043

5.0(2)
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Fiches techniques
  • L'Anticorps SPA-1 (C-1) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
  • dirigé contre les acides aminés 691-990 situés près du C-terminus de SPA-1 de human
  • recommandé pour la détection de SPA-1 d'origine human par WB, IP, IF, IHC(P) et ELISA
  • m-IgG Fc BP-HRP et m-IgG1 BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps SPA-1 (C-1) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps SPA-1 (C-1) (voir Informations pour la commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    The SPA-1 (signal-induced proliferation-associated gene-1) protein is a principal RAP1 GTPase-activating protein in the hematopoietic progenitors and peripheral T cells. The SPA-1 gene is normally expressed in fetal and adult lymphohematopoietic tissues. Various types of mitogenic stimulation increase SPA-1 mRNA expression in normal lymphocytes. SPA-1 disrupts LFA-1-ICAM1-mediated adhesive interactions and subsequent T cell-receptor triggering and IL-2 production, possibly through inhibition of RAP1. Mice that are deficient for the SPA-1 gene develop age-dependent progression of T cell immunodeficiency followed by a spectrum of late onset myeloproliferative disorders, mimicking human chronic myeloid leukemia. SPA-1 also directly binds to AQP2 and plays a role in regulating AQP2 trafficking to the apical membrane.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps SPA-1 (C-1)

    sc-137043
    200 µg/ml
    RMB2377.00

    SPA-1 (C-1): m-IgG Fc BP-HRP Kit

    sc-539922
    200 µg Ab; 10 µg BP
    RMB2662.00

    SPA-1 (C-1): m-IgG1 BP-HRP Kit

    sc-541789
    200 µg Ab; 20 µg BP
    RMB2662.00

    Can SPA-1 (C-1): sc-137043 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Posée par: jenniferc
    Thank you for your question. Yes, SPA-1 (C-1): sc-137043 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Répondue par: Technical Support
    Date de publication: 2017-03-01
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    Rated 5 de 5 de par Produced beautiful immunoperoxidase membraneProduced beautiful immunoperoxidase membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
    Date de publication: 2015-05-02
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    Anticorps SPA-1 (C-1) est évalué 5.0 de 5 de 2.
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