TEX22 inhibitors are a class of chemical compounds designed to selectively interfere with the function of the TEX22 protein. TEX22, a member of the testis-expressed (TEX) protein family, plays a role in specific cellular pathways, often related to its expression in certain tissues or cell types. Inhibitors targeting TEX22 are structured to bind to specific sites on the protein, thereby modulating its normal biological activity. These compounds typically exhibit high affinity for TEX22, enabling researchers to study the protein's role in various molecular processes. The design of TEX22 inhibitors is often guided by structural biology insights, such as crystallography or computational modeling, which help to identify binding sites and key interactions critical for their inhibitory effects. Chemical synthesis of these inhibitors can involve modifications to enhance binding efficiency, stability, or selectivity for TEX22 over related proteins.
In experimental settings, TEX22 inhibitors are valuable tools for probing the molecular and biochemical pathways regulated by TEX22. By inhibiting TEX22 activity, researchers can observe downstream effects and better understand how TEX22 interacts with other proteins or cellular systems. The development of these inhibitors involves rigorous testing, including the examination of their binding kinetics, specificity, and their effects on protein conformation. Studies often focus on the molecular dynamics and structural changes that occur when TEX22 is inhibited, providing insights into its biological roles. These inhibitors are crucial for dissecting the fundamental biology of TEX22, offering a window into the complex regulatory networks that involve this protein and its associated functions.
関連項目
Items 1 to 10 of 12 total
展示:
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | ¥3554.00 | ||
细胞周期依赖性激酶CDK4和CDK6的选择性抑制剂。TEX22的功能可能通过细胞周期调节途径受到影响,因为这些激酶对于细胞周期从G1期到S期的进展至关重要。 | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | ¥632.00 ¥2392.00 ¥8619.00 | 24 | |
MDM2拮抗剂可防止MDM2-p53相互作用,从而稳定并激活p53。激活p53可导致细胞周期停滞,从而通过限制TEX22表达细胞的增殖来间接抑制TEX22。 | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | ¥1681.00 ¥5303.00 ¥6995.00 ¥13527.00 ¥23579.00 | 33 | |
组蛋白去乙酰化酶抑制剂,可导致组蛋白过度乙酰化,从而改变染色质结构和基因表达。这可能会通过改变TEX22功能所需的基因表达来抑制TEX22。 | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | ¥632.00 ¥2933.00 ¥11056.00 | 163 | |
一种蛋白酶体抑制剂,可防止泛素化蛋白降解,从而可能导致细胞周期停滞和细胞凋亡。这可能会通过破坏蛋白质稳态和细胞分裂过程来降低TEX22的活性。 | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | ¥2053.00 ¥7818.00 | 88 | |
Rho相关蛋白激酶(ROCK)抑制剂,在肌动蛋白细胞骨架组织中发挥作用。改变细胞骨架动态会影响细胞分裂,从而可能降低TEX22活性。 | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | ¥440.00 ¥1015.00 | 212 | |
MEK 抑制剂会损害参与细胞增殖和存活的 MAPK/ERK 信号通路。这可能会阻碍对睾丸发育和功能至关重要的途径,从而降低 TEX22 的活性。 | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | ¥1365.00 ¥4423.00 | 148 | |
PI3K抑制剂,可抑制AKT信号通路。这可通过影响TEX22所涉及的细胞存活和生长所必需的通路来降低TEX22的活性。 | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | ¥903.00 ¥2392.00 ¥4603.00 | 48 | |
TGF-β受体激酶 ALK4、ALK5 和 ALK7 的抑制剂,影响细胞分化和增殖。这可能会间接降低 TEX22 在发育过程中的活性。 | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | ¥699.00 ¥1749.00 ¥3610.00 | 233 | |
mTOR 抑制剂,通过抑制 mTORC1 复合物影响细胞生长、增殖和存活。这可能会减少 TEX22 可能参与的细胞过程,从而削弱其活性。 | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | ¥711.00 ¥2719.00 | 136 | |
MEK1/2 的抑制剂,MEK1/2 是 MAPK/ERK 通路的一部分。这可能会影响对细胞生长和分裂至关重要的信号通路,从而间接抑制 TEX22 的作用。 |