eIF4B激活剂
The chemical class of eIF4B activators comprises a range of compounds that can directly or indirectly modulate the activation of eIF4B, a crucial player in translation initiation. 4EGI-1 disrupts the eIF4E/eIF4G interaction, indirectly influencing eIF4B activation by impacting the eIF4F complex. Rapamycin and LY2584702 target the mTOR pathway, indirectly regulating eIF4B through mTOR-mediated translation initiation. Rocaglamide inhibits eIF4A helicase activity, indirectly affecting eIF4B by disrupting mRNA secondary structure unwinding. CGP 57380 inhibits p38 MAP kinase, influencing eIF4B activation through its regulatory pathways. PF-4708671 inhibits AMPK, indirectly impacting eIF4B by modulating the negative regulation from the AMPK-mTOR axis. CCG-1423 affects Rho/MRTF/SRF signaling, indirectly modulating eIF4B activation connected to various cellular cascades.
BI-D1870 inhibits RSK, indirectly influencing eIF4B activation through the MAPK pathway. ISRIB enhances eIF2B activity, indirectly impacting eIF4B through eIF2B-mediated translation initiation. TAK-632 inhibits MEK, indirectly modulating eIF4B through the MAPK/ERK pathway. SBI-0640756 inhibits PERK, indirectly influencing eIF4B through the unfolded protein response (UPR) pathway. CCT020312 inhibits MNK1/2, indirectly modulating eIF4B by altering eIF4E phosphorylation status. This diverse array of eIF4B activators provides researchers with valuable tools to explore the intricate regulation of translation initiation processes in various biological contexts.
| 产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
|---|---|---|---|---|---|---|
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | 315706-13-9 | sc-202597 | 10 mg | ¥2933.00 | 14 | |
4EGI-1 是一种 eIF4E/eIF4G 相互作用的小分子抑制剂。通过破坏 eIF4E 和 eIF4G 的结合，它间接影响了 eIF4F 复合物，从而有可能调节 eIF4B 的活化。 | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | ¥699.00 ¥1749.00 ¥3610.00 | 233 | |
雷帕霉素是一种mTOR抑制剂，可以间接影响eIF4B的激活。由于mTOR调节翻译起始过程，包括eIF4B的活性，因此雷帕霉素对mTOR的抑制会影响eIF4B的功能。 | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | ¥3046.00 ¥5246.00 ¥18130.00 ¥27618.00 ¥59106.00 | 4 | |
Rocaglamide 是一种抑制 eIF4A 螺旋酶活性的天然化合物。由于 eIF4A 在翻译启动过程中参与了 mRNA 二级结构的解链，因此洛克酰胺对 eIF4A 的抑制作用会间接影响 eIF4B 的激活。 | ||||||
CGP 57380 | 522629-08-9 | sc-202993 | 5 mg | ¥1941.00 | 6 | |
CGP 57380 是 p38 MAP 激酶的化学抑制剂。由于 p38 MAP 激酶与 eIF4B 的调控有关，CGP 57380 对 p38 MAP 激酶的抑制可通过调节其调控途径间接影响 eIF4B 的激活。 | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | ¥1974.00 ¥7897.00 | 9 | |
PF-4708671 是一种 AMP 活化蛋白激酶（AMPK）抑制剂。由于 AMPK 可负向调节 mTOR，进而调节 eIF4B，因此 PF-4708671 对 AMPK 的抑制可通过影响 mTOR 信号通路间接影响 eIF4B 的激活。 | ||||||
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | ¥338.00 ¥1015.00 | 8 | |
CCG-1423是Rho/MRTF/SRF转录信号的抑制因子。通过影响该信号通路，CCG-1423可以间接调节eIF4B的激活，因为eIF4B的调节与各种细胞信号级联密切相关。 | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | ¥1015.00 ¥3103.00 | 12 | |
BI-D1870是一种RSK（p90核糖体S6激酶）的化学抑制剂，RSK通过MAPK途径调节eIF4B。它对RSK的抑制可通过调节下游信号通路间接影响eIF4B的激活。 | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | ¥3385.00 | 1 | |
ISRIB是一种小分子，可增强eIF2B的活性。由于eIF2B参与翻译起始的调节，包括eIF4B的激活，ISRIB对eIF2B的作用可间接调节eIF4B的功能。 | ||||||
TAK 632 | 1228591-30-7 | sc-473801 | 5 mg | ¥2527.00 | ||
TAK-632是一种强效且选择性的MEK抑制剂。TAK-632通过抑制MEK影响MAPK/ERK通路，从而间接调节eIF4B的激活，因为MAPK/ERK通路与翻译起始调控密切相关。 | ||||||