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TRAF2 抗体 (G-3): sc-136998

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说明书
  • TRAF2抗体(G-3)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 免疫human物种的TRAF2的氨基酸1-249
  • 推荐用于 mouse, rat 和 human 来源的TRAF2 WB, IP, IF 和 ELISA检测
  • 看 TRAF2 (F-2): sc-136999,可查看有标记的 TRAF2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是TRAF2 Antibody (G-3) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与TRAF2 Antibody (G-3) 打包提供(请参阅下面的订购信息)。
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    関連項目

    肿瘤坏死因子(TNF)激活的细胞信号传导主要通过TNF受体1(TNF-R1)介导,其次是通过TNF-R2介导。两种TNF受体都是不断扩大的TNF受体超家族的成员,该家族包括FAS抗原和CD40。通过鉴定两种相关蛋白TRAF1和TRAF2(分别为TNF受体相关因子1和2),为理解TNF受体介导的信号传导提供了潜在的见解。这两种蛋白都起着形成异二聚体复合物并与TNF-R2的细胞质结构域结合的作用。该蛋白质家族的第三个成员,也称为CD40 bp、CRAF1、LAP1或TRAF3,已被鉴定并显示与CD40的细胞质结构域结合。TRAF3的特定区域与TRAF1和TRAF2区域之间的相似性定义了一个"TRAF-C"结构域,该结构域对于CD40结合和同二聚化是必要且充分的。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    TRAF2 抗体 (G-3) 参考文献:

    1. TRAF2在TNF受体诱导的NF-κB、MAP激酶和细胞死亡信号转导中的多重任务。  |  Borghi, A., et al. 2016. Biochem Pharmacol. 116: 1-10. PMID: 26993379
    2. cIAP1/TRAF2相互作用通过激活STAT3促进肿瘤生长。  |  Dumétier, B., et al. 2023. Oncogene. 42: 198-208. PMID: 36400972
    3. 去泛素化酶OTUD7b通过稳定E3连接酶TRAF2,保护树突状细胞免受TNF诱导的凋亡。  |  Harit, K., et al. 2023. Cell Death Dis. 14: 480. PMID: 37516734
    4. TRAF2/3缺陷的B细胞通过NF-κB2/XIAP/cIAP2轴抵抗DNA损伤诱导的细胞凋亡,而IAP拮抗剂使突变淋巴瘤对化疗药物敏感。  |  Vashisht, M., et al. 2023. Cell Death Dis. 14: 599. PMID: 37679334
    5. 天然化合物Sanggenon C通过调节TRAF2/NF-κB信号通路抑制PRRSV感染。  |  Liu, X., et al. 2023. Vet Res. 54: 114. PMID: 38037100
    6. 沉默CPNE1-TRAF2轴抑制胰腺癌的发展。  |  Song, Y., et al. 2023. Front Biosci (Landmark Ed). 28: 316. PMID: 38062811
    7. Traf2和NcK相互作用激酶抑制剂NCB-0846通过减少GRIA1来抑制癫痫发作。  |  Wang, M., et al. 2024. Genes Dis. 11: 100997. PMID: 38292191
    8. E3泛素连接酶的CRISPR-Cas9筛选鉴定TRAF2和UHRF1为人类原代T细胞中HIV潜伏的调节因子。  |  Rathore, U., et al. 2024. mBio. 15: e0222223. PMID: 38411080
    9. 在妊娠早期,B(a)P通过TRAF2-NFκB-Caspase1轴诱导卵巢颗粒细胞凋亡。  |  Xu, H., et al. 2024. Environ Res. 252: 118865. PMID: 38583661
    10. USP24通过去泛素化和稳定TRAF2促进肝细胞癌的肿瘤发生。  |  Zhou, N., et al. 2024. Biochem Pharmacol. 229: 116473. PMID: 39127151

    订购信息

    产品名称产品编号规格价格数量收藏夹

    TRAF2 抗体 (G-3)

    sc-136998
    200 µg/ml
    CNY2422.00

    TRAF2 (G-3): m-IgG Fc BP-HRP 套装

    sc-537385
    200 µg Ab; 10 µg BP
    CNY2715.00

    TRAF2 (G-3): m-IgGκ BP-HRP 套装

    sc-534636
    200 µg Ab; 40 µg BP
    CNY2715.00

    What is the recommended fixation method for immunofluorescence staining with TRAF2 (G-3): sc-136998 monoclonal antibody?

    Asked by: jerojero
    Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
    Answered by: Technical Support
    Date published: 2017-03-01
    • y_2026, m_10, d_23, h_6CST
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    Rated 5 out of 5 by 1 from used this antibody for WB in human cellsused this antibody for WB in human cells and worked great.
    Date published: 2015-10-08
    Rated 5 out of 5 by ET from StrongStrong, specific band in WB in mouse TRAF2 transfected 293T whole cell lysate. -SCBT QC
    Date published: 2015-05-17
    Rated 5 out of 5 by SF from Good band in WB in Jurkat whole cell lysateGood band in WB in Jurkat whole cell lysate. -SCBT QC
    Date published: 2015-03-23
    Rated 5 out of 5 by SF from StrongStrong, specific band in WB in human TRAF2 transfected 293T whole cell lysate. -SCBT QC
    Date published: 2015-01-28
    Rated 5 out of 5 by ET from ClearClear, specific bands in WB in HeLa and A-431 whole cell lysates. -SCBT QC
    Date published: 2013-11-23
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    TRAF2 抗体 (G-3) is rated 5.0 out of 5 by 5.
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