Date published: 2025-9-7
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TRAF2 Antibody (H-10) - Western Blotting - Image 3203
TRAF2 抗体 (H-10): sc-7346. 转染 TRAF2 的 COS 细胞中 TRAF2 表达的 Western 印迹分析.
TRAF2 抗体 (H-10): sc-7346. 转染 TRAF2 的 COS 细胞中 TRAF2 表达的 Western 印迹分析.

TRAF2 抗体 (H-10): sc-7346

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说明书
  • TRAF2抗体(H-10)是小鼠单克隆IgG1 λ, 在36篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于mouse物种的TRAF2的C-terminus的氨基酸478-497之间
  • 抗-TRAF2 抗体 (H-10) 推荐用于 WB, IP, IF, IHC(P), FCM 和 ELISA，检测mouse, rat 和human 来源的 TRAF2; 也和以下物种反应，包括： 和 canine and bovine
  • 抗TRAF2抗体（H-10）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取TRAF2 (H-10): sc-7346的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP)是 TRAF2 抗体 (H-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与TRAF2 抗体 (H-10) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGλ BP 偶联产品，请参阅我们的 小鼠 IgG 结合蛋白完整列表。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 TRAF 抗体 包括 TRAF1, TRAF2, TRAF3, TRAF4, TRAF5和TRAF6

TRAF2抗体（H-10）是一种小鼠单克隆IgG1抗体，可通过多种应用检测小鼠、大鼠和人类样本中的TRAF2，包括蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学、流式细胞术（FCM）和酶联免疫吸附测定（ELISA）。TRAF2抗体（H-10）有非结合型和多种结合型，如琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和各种Alexa Fluor®结合物。TRAF2在介导肿瘤坏死因子（TNF）信号传导中起着至关重要的作用，主要通过与TNF受体1（TNF-R1）相互作用，并在较小程度上与TNF受体2（TNF-R2）相互作用。TRAF2位于细胞质中，在那里TRAF2与TRAF1形成异二聚体复合物，并与TNF受体的细胞质结构域结合，促进下游信号传导通路，对免疫反应和炎症至关重要。TRAF2的功能对于调节细胞存活、增殖和凋亡至关重要，这使得TRAF2在包括癌症和自身免疫性疾病在内的各种病理条件下扮演着重要角色。了解TRAF2的动态和相互作用可以为针对TNF受体介导的信号通路的疗法提供宝贵的见解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TRAF2 抗体 (H-10) 参考文献:

  1. 两种 TNF 受体  |  Tartaglia, LA. and Goeddel, DV. 1992. Immunol Today. 13: 151-3. PMID: 1322675
  2. Celastrol 诱导的 Nur77 与 TRAF2 的相互作用可通过促进线粒体泛素化和自噬缓解炎症。  |  Hu, M., et al. 2017. Mol Cell. 66: 141-153.e6. PMID: 28388439
  3. TRAF2 可通过抑制坏死保护缺血诱导的脑损伤。  |  Li, J., et al. 2019. Cell Death Dis. 10: 328. PMID: 30988281
  4. 蛋白酶体降解TRAF2介导多柔比星-心肌病中的线粒体功能障碍。  |  Dhingra, R., et al. 2022. Circulation. 146: 934-954. PMID: 35983756
  5. TRAF2-p62轴通过激活mTORC1通路促进肝癌的增殖和存活。  |  Liang, X., et al. 2023. Cell Death Differ. 30: 1550-1562. PMID: 37081115
  6. TRAF2通过抑制透明细胞肾细胞癌中的自噬，促进M2极化肿瘤相关巨噬细胞浸润、血管生成和癌症进展。  |  Xu, Y., et al. 2023. J Exp Clin Cancer Res. 42: 159. PMID: 37415241
  7. 一种新型 RING 手指蛋白与 CD40 的细胞质结构域相互作用。  |  Hu, HM., et al. 1994. J Biol Chem. 269: 30069-72. PMID: 7527023
  8. CRAF1是TRAF的亲戚，它参与了CD40信号传导。  |  Cheng, G., et al. 1995. Science. 267: 1494-8. PMID: 7533327
  9. TNF 受体 1 相关蛋白 TRADD 发出细胞死亡和 NF-kappa B 激活信号。  |  Hsu, H., et al. 1995. Cell. 81: 495-504. PMID: 7758105
  10. Epstein-Barr 病毒转化蛋白 LMP1 与肿瘤坏死因子受体家族的信号蛋白结合。  |  Mosialos, G., et al. 1995. Cell. 80: 389-99. PMID: 7859281
  11. 与 75 kDa 肿瘤坏死因子受体胞质结构域缔合作用的新型假定信号转导子家族。  |  Rothe, M., et al. 1994. Cell. 78: 681-92. PMID: 8069916
  12. 细胞和病毒蛋白 TNF 受体超家族：激活, 成本刺激和死亡。  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429

订购信息

产品名称产品编号规格价格数量收藏夹

TRAF2 抗体 (H-10)

sc-7346
200 µg/ml
$316.00

TRAF2 (H-10): m-IgGλ BP-HRP 套装

sc-520497
200 µg Ab, 40 µg BP
$354.00

TRAF2 抗体 (H-10) AC

sc-7346 AC
500 µg/ml, 25% agarose
$416.00

TRAF2 抗体 (H-10) HRP

sc-7346 HRP
200 µg/ml
$316.00

TRAF2 抗体 (H-10) FITC

sc-7346 FITC
200 µg/ml
$330.00

TRAF2 抗体 (H-10) PE

sc-7346 PE
200 µg/ml
$343.00

TRAF2 抗体 (H-10) Alexa Fluor® 488

sc-7346 AF488
200 µg/ml
$357.00

TRAF2 抗体 (H-10) Alexa Fluor® 546

sc-7346 AF546
200 µg/ml
$357.00

TRAF2 抗体 (H-10) Alexa Fluor® 594

sc-7346 AF594
200 µg/ml
$357.00

TRAF2 抗体 (H-10) Alexa Fluor® 647

sc-7346 AF647
200 µg/ml
$357.00

TRAF2 抗体 (H-10) Alexa Fluor® 680

sc-7346 AF680
200 µg/ml
$357.00

TRAF2 抗体 (H-10) Alexa Fluor® 790

sc-7346 AF790
200 µg/ml
$357.00

TRAF2 (H-10) 中和勝肽

sc-7346 P
100 µg/0.5 ml
$68.00

Dear Sir/Madam, I am a post-doc at Newcastle University working with cellular ageing. Would it be possible to receive a free sample of "TRAF2 (H-10): sc-7346"? If the antibody works I will buy this product. Kind regards, Mikolaj

Asked by: Mikolaj Ogrodnik
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-14

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 3
Date published: 2017-01-13

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with TRAF2 (H-10): sc-7346?

Asked by: jerojero
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 3
Date published: 2017-01-13
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Rated 5 out of 5 by from Good antibodyIt is good staining, clear band. I use 1:1000 for WB.
Date published: 2019-07-27
Rated 5 out of 5 by from Very good antibody fVery good antibody for detecting TRAF2 binding is very specific in ELISA. Used in concentration of 1:300.
Date published: 2017-08-19
Rated 5 out of 5 by from 1:800 dilutionI recommend use this antibody at 1:400 to 1:800 dilution,we can use mouse liver tissue as positive control,its expression is high.
Date published: 2017-06-14
Rated 5 out of 5 by from Good stainingGood staining pattern, it is great for IHC staining,1:400 used.
Date published: 2017-05-28
Rated 5 out of 5 by from Best TRAF2 antibody !!Outstanding for western blot, IHC staining and IF !!
Date published: 2017-01-19
Rated 5 out of 5 by from clearWorked very well for detection for TRAF2, clear and sensitive.
Date published: 2017-01-12
Rated 5 out of 5 by from Good for staining in paraffin tissueThis antibody shows strong signal for Immunoperoxidase staining in human tissue samples.
Date published: 2017-01-11
Rated 1 out of 5 by from Not good for WBNot a good antibody for WB. I used murine microglia, but got no clear band.
Date published: 2016-11-12
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TRAF2 抗体 (H-10) is rated 4.7 out of 5 by 15.
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