Date published: 2025-9-7

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TIP120A 抗体 (D-9): sc-373718

5.0(2)
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说明书
  • TIP120A抗体(D-9)是小鼠单克隆IgM (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于rat物种的TIP120A的N-terminus的氨基酸2-21之间
  • 推荐用于 mouse, rat 和 human 来源的TIP120A WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine and porcine
  • 可用于ChIP的TransCruz试剂(sc-373718 X, 200 µg/0.1 ml)
  • 目前,我们还没有完成TIP120A 抗体 (D-9)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    TATA结合蛋白(TBP)与各种核蛋白形成复合物,是各种转录调节因子的靶标,如TIP120。TIP120蛋白家族的两个成员TIP120A和TIP120B是TBP相互作用蛋白,在转录调节中起全局激活剂的作用。TIP120A是从大鼠肝核提取物中分离出的广泛表达的蛋白质,最初命名为TIP120。TIP120B是一种TIP-120A样蛋白质,特异性表达于肌肉组织中。TIP120A直接与TBP和RNA聚合酶(RNAP)的特定亚基结合,以促进RNAP II特异性整合到预起始复合物(PIC)中。除了作为TBP的转录因子外,对RNA聚合酶的伴侣样活性表明TIP120调节多个基因表达的扩增。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    TIP120A 抗体 (D-9) 参考文献:

    1. NEDD8 对 CUL1 的修饰可解离 p120(CAND1),p120(CAND1)是 CUL1-SKP1 结合和 SCF 连接酶的抑制剂。  |  Liu, J., et al. 2002. Mol Cell. 10: 1511-8. PMID: 12504025
    2. 将抑制剂 Cand1 募集到 cullin 底物适配位点可介导与 neddylation 位点的相互作用。  |  Helmstaedt, K., et al. 2011. Mol Biol Cell. 22: 153-64. PMID: 21119001
    3. COMMD1(含铜代谢 MURR1 结构域蛋白 1)通过阻止 CAND1(Cullin-associated Nedd8-dissociated protein 1)结合来调节 Cullin RING 连接酶。  |  Mao, X., et al. 2011. J Biol Chem. 286: 32355-65. PMID: 21778237
    4. CAND1 促进 PLK4 介导的中心粒过度复制,在前列腺癌中经常被破坏。  |  Korzeniewski, N., et al. 2012. Neoplasia. 14: 799-806. PMID: 23019411
    5. Cand1 通过 F 盒蛋白的动态交换促进新 SCF 复合物的组装。  |  Pierce, NW., et al. 2013. Cell. 153: 206-15. PMID: 23453757
    6. CAND1控制着cullin 1-RING 泛素连接酶的体内动态。  |  Wu, S., et al. 2013. Nat Commun. 4: 1642. PMID: 23535663
    7. CAND1交换因子在脂肪生成过程中促进Keap1整合到cullin 3-RING 泛素连接酶中。  |  Dubiel, D., et al. 2015. Int J Biochem Cell Biol. 66: 95-100. PMID: 26219975
    8. miR-33a 通过靶向 CAND1 抑制肺癌细胞增殖和侵袭  |  Kang, M., et al. 2018. Clin Transl Oncol. 20: 457-466. PMID: 28871425
    9. LncRNA RMRP敲除通过介导 miR-766-5p/CAND1 轴促进许旺细胞的增殖和迁移。  |  Zhou, L., et al. 2022. Neurosci Lett. 770: 136440. PMID: 34974108
    10. GSTM3 缺乏会阻碍 DNA 错配修复,从而通过 CAND1/NRF2-KEAP1 信号传导促进胃肿瘤发生。  |  Chen, T., et al. 2022. Cancer Lett. 538: 215692. PMID: 35487311

    订购信息

    产品名称产品编号规格价格数量收藏夹

    TIP120A 抗体 (D-9)

    sc-373718
    200 µg/ml
    RMB2377.00

    TIP120A (D-9) 中和勝肽

    sc-373718 P
    100 µg/0.5 ml
    RMB511.00

    TIP120A 抗体 (D-9) X

    sc-373718 X
    200 µg/0.1 ml
    RMB2377.00

    What application is the blocking peptide sc-373718 P appropriate for?

    Asked by: Trav11
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Produced superb immunofluorescence nuclearProduced superb immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
    Date published: 2015-02-10
    Rated 5 out of 5 by from Nice Western Blot data of TIP120A expressionNice Western Blot data of TIP120A expression in HeLa and Jurkat nuclear extracts. -SCBT QC
    Date published: 2013-06-17
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    TIP120A 抗体 (D-9) is rated 5.0 out of 5 by 2.
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