Date published: 2025-9-8
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RUNX2 Antibody (27-K) - Western Blotting - Image 34505
RUNX2 抗体 (27-K): sc-101145. K-562 全细胞裂解液中 RUNX2 表达的 Western 印迹分析.
RUNX2 Antibody (27-K) - Western Blotting - Image 34505
RUNX2 抗体 (27-K): sc-101145. K-562 全细胞裂解液中 RUNX2 表达的 Western 印迹分析.
RUNX2 Antibody (27-K) - Immunohistochemistry - Image 36311
RUNX2 抗体 (27-K): sc-101145. 福尔马林固定, 石蜡包埋的人胎盘组织的免疫过氧化物酶染色, 显示核定位.
RUNX2 抗体 (27-K): sc-101145. K-562 全细胞裂解液中 RUNX2 表达的 Western 印迹分析.

RUNX2 抗体 (27-K): sc-101145

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说明书
  • RUNX2 抗体 27-K 是小鼠单克隆 IgG2b, 在105篇文献中引用，提供 50 µg/0.5 ml
  • 免疫human物种的重组RUNX2
  • 推荐用于 mouse, rat 和 human 来源的RUNX2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 RUNX2 (F-2): sc-390351，可查看有标记的 RUNX2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取RUNX2 (27-K): sc-101145的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成RUNX2 抗体 (27-K)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 RUNX 抗体 包括 RUNX1, RUNX2和RUNX3

RUNX2抗体（27-K）是一种IgG2b小鼠单克隆RUNX2抗体，它通过WB、IP、IF、IHC（P）和ELISA检测小鼠、大鼠和人类来源的RUNX2。RUNX2抗体（27-K）以非偶联的抗RUNX2抗体形式提供。哺乳动物的Runt相关转录因子（RUNX）家族包括三个成员，RUNX1（也称为AML-1、PEBP2αB、CBFA2）、RUNX2（也称为AML-3、PEBP2αA、CBFA1、Osf2）和RUNX3（也称为AML-2、PEBP2αC、CBFA3）。RUNX家族成员是结合DNA的蛋白质，可调节涉及细胞分化和细胞周期进程的基因的表达。RUNX2对于骨骼矿化是必不可少的，因为它能刺激间充质干细胞的成骨分化，促进软骨细胞肥大，并有助于内皮细胞迁移和发育中骨骼的血管侵袭。调节RUNX2的表达可能成为促进骨形成的有用治疗工具。RUNX2的C末端突变与锁骨颅骨发育不良综合征有关，这是一种常染色体显性骨骼发育不良综合征，其特征是颅缝广泛开放、锁骨发育不全、多生牙和身材矮小。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

RUNX2 抗体 (27-K) 参考文献:

  1. PEBP2/CBF 与 Smads 的相互作用和功能合作。协同诱导免疫球蛋白种系Calpha启动子。  |  Hanai, J., et al. 1999. J Biol Chem. 274: 31577-82. PMID: 10531362
  2. Runx 蛋白在软骨形成过程中的作用  |  Yoshida, CA. and Komori, T. 2005. Crit Rev Eukaryot Gene Expr. 15: 243-54. PMID: 16390320
  3. Runx2 的转录共抑制因子。  |  Westendorf, JJ. 2006. J Cell Biochem. 98: 54-64. PMID: 16440320
  4. 颅顶骨发育不良伴严重顶骨发育不良：C端RUNX2突变。  |  Cunningham, ML., et al. 2006. Birth Defects Res A Clin Mol Teratol. 76: 78-85. PMID: 16463420
  5. 纯化能与多瘤病毒增强子 A 核和 B 核结合的小鼠核因子。  |  Kamachi, Y., et al. 1990. J Virol. 64: 4808-19. PMID: 2168969
  6. Runx2对成骨细胞增殖、分化及功能的调节。  |  Komori, T. 2019. Int J Mol Sci. 20: PMID: 30987410
  7. Runx2在骨骼发育中的整体功能。  |  Komori, T. 2022. Int J Mol Sci. 23: PMID: 35628587
  8. Runx2通过转录调控Itgav的表达来激活肝星状细胞，促进肝纤维化。  |  Zhong, L., et al. 2023. Clin Transl Med. 13: e1316. PMID: 37403784
  9. PEBP2/PEA2 是一个转录因子家族，与果蝇 runt 基因和人类 AML1 基因的产物同源。  |  Ogawa, E., et al. 1993. Proc Natl Acad Sci U S A. 90: 6859-63. PMID: 8341710
  10. 新型果蝇 RUNT 相关 DNA 结合蛋白 PEBP2 alpha 的异源二聚体伙伴 PEBP2 beta 的分子克隆和表征。  |  Ogawa, E., et al. 1993. Virology. 194: 314-31. PMID: 8386878
  11. Osf2/Cbfa1：成骨细胞分化的转录激活因子。  |  Ducy, P., et al. 1997. Cell. 89: 747-54. PMID: 9182762
  12. 涉及转录因子 CBFA1 的突变会导致颅裂发育不良。  |  Mundlos, S., et al. 1997. Cell. 89: 773-9. PMID: 9182765

订购信息

产品名称产品编号规格价格数量收藏夹

RUNX2 抗体 (27-K)

sc-101145
50 µg/0.5 ml
RMB2504.00

Do you offer Fab fragmentation service for this specific antibody?

Asked by: Junxi
Thank you for your question. We do not offer fragmentation services.
Answered by: BlakeJ
Date published: 2025-06-23

Is RUNX2 Antibody (27-K): sc-101145 available directly conjugated to HRP or fluorescent dyes?

Asked by: jenni
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at [email protected] Alternatively, consider using RUNX2 (F-2), which is available conjugated to AC, HRP, FITC, PE, Alexa Fluor® 488 and Alexa Fluor® 647. (https://www.scbt.com/scbt/product/runx2-antibody-f-2)
Answered by: Technical Support 2
Date published: 2017-01-10

Bonjour je possède un AC réf : sc-101145, anti-RUNX2 dont je ne connais pas la date de fabrication, ni la date d'achat. Pourriez-vous avec le numéro de lot indiqué sur le tube : lot : # D2809, me dire de quand date ce tube d'anticorps ?

Asked by: Danièle Inserm U938
Merci pour votre question. Les tubes du lot D2809 ont été entièrement vendus et ce lot est épuisé. Nous vous contacterons par email pour plus de précisions quant à votre adresse de livraison et déterminer ainsi la date d'achat. --- Thank you very much for your question. The lot D2809 was sold out successfully. We will contact you by email to follow up regarding your shipping address to determine the shipping date.
Answered by: Technical Support Europe
Date published: 2016-11-24
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Rated 5 out of 5 by from Worked well in Mesenchymal Stem CellsUsed the sample product to stain MSCs/osteoblasts. Used 1:250 dilution.
Date published: 2019-09-12
Rated 5 out of 5 by from 功能很出色一个月前购买此产品，总蛋白20ug，1:500稀释后WB效果很好,一条带，无非特异性条带，准备在稀释一下抗体试试。
Date published: 2018-12-05
Rated 3 out of 5 by from Decent ab.Decent antibody. used at 1:500 on 15ug of bone homogenates from mice femurs.
Date published: 2018-05-22
Rated 5 out of 5 by from Work well!1:500 diluted for wb of rat protein,the band is strong and special
Date published: 2018-04-11
Rated 5 out of 5 by from WBWe are happy to detect the levels of target protein in mouse brain tissue. I got very strong band at 1:500 dilution.
Date published: 2017-09-02
Rated 5 out of 5 by from wonderful antibodyIt's well worked in WB for studying BMSCs osteogenesis
Date published: 2017-07-18
Rated 5 out of 5 by from specific signalWe use this antibody very often by WB, gives very good signal,1:400 dilution .
Date published: 2017-05-31
Rated 5 out of 5 by from dilution 1:500I have got what I want. it give me a surprise, very nice band
Date published: 2017-03-15
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RUNX2 抗体 (27-K) is rated 4.9 out of 5 by 16.
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