Date published: 2025-9-7
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p-mTOR Antibody (Ser 2481 55.42) - Immunohistochemistry - Image 352289
p-mTOR 抗体 (Ser 2481 55. 42): sc-293089. 福尔马林固定, 石蜡包埋的人前列腺组织的免疫过氧化物酶染色显示腺细胞的膜染色和平滑肌细胞的胞浆染色.
p-mTOR Antibody (Ser 2481 55.42) - Immunohistochemistry - Image 352289
p-mTOR 抗体 (Ser 2481 55. 42): sc-293089. 福尔马林固定, 石蜡包埋的人前列腺组织的免疫过氧化物酶染色显示腺细胞的膜染色和平滑肌细胞的胞浆染色.
p-mTOR Antibody (Ser 2481 55.42) - Immunohistochemistry - Image 352290
p-mTOR 抗体 (Ser 2481 55. 42): sc-293089. 福尔马林固定, 石蜡包埋的人类睾丸组织的免疫过氧化物酶染色, 显示曲细精管中细胞的膜和细胞质染色以及 Leydig 细胞的细胞质染色.
p-mTOR Antibody (Ser 2481 55.42) - Immunohistochemistry - Image 352291
p-mTOR 抗体 (Ser 2481 55. 42): sc-293089. 福尔马林固定, 石蜡包埋的人骨骼肌组织的免疫过氧化物酶染色, 显示肌细胞的胞浆染色.
p-mTOR 抗体 (Ser 2481 55. 42): sc-293089. 福尔马林固定, 石蜡包埋的人前列腺组织的免疫过氧化物酶染色显示腺细胞的膜染色和平滑肌细胞的胞浆染色.

p-mTOR 抗体 (Ser 2481 55.42): sc-293089

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说明书
  • p-mTOR抗体(Ser 2481 55.42)是小鼠单克隆IgG1 κ, 在37篇文献中引用，规格为200 µg/ml
  • 与mTOR的human来源的合成肽发生反应
  • 推荐用于 human 来源的Ser 2481 phosphorylated mTOR WB, IF, IHC(P) 和 ELISA检测
  • 还可偶联琼脂糖 用于IP; 偶联HRP 用于WB, IHC(P) 和ELISA
  • 关于如何获取p-mTOR (Ser 2481 55.42): sc-293089的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 p-mTOR 抗体 (Ser 2481 55.42) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与p-mTOR 抗体 (Ser 2481 55.42) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

p-mTOR抗体（Ser 2481 55.42）是一种IgG1 κ小鼠单克隆p-mTOR抗体，可通过WB、IF、IHC(P)和ELISA检测人源Ser 2481磷酸化的mTOR。p-mTOR抗体（Ser 2481 55.42）既有偶联形式，也有非偶联形式的抗p-mTOR抗体。PIK相关激酶包括Atm、DNA-PKCS和mTOR。Atm基因在常染色体隐性遗传疾病共济失调毛细血管扩张症（AT）中发生突变，该疾病以小脑退化和眼结膜血管扩张为特征。AT细胞对电离辐射超敏感，在介导DNA合成的抑制方面存在缺陷，并且显示p53诱导的延迟。DNA-PK是一种异三聚体DNA结合酶，由一个大亚基DNA-PKCS和两个较小亚基（统称为Ku）组成。DNA-PK的丧失导致DSB修复和V(D)J重组的缺陷。mTOR，也称为FRAP，可以在丝氨酸上自磷酸化并结合雷帕霉素/FKBP。mTOR也是S6激酶的上游调节因子，并已涉及p27和p21表达的调节。mTOR在翻译抑制条件下在Ser2481处自磷酸化。mTOR在Ser2448处的磷酸化由p70S6激酶介导。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-mTOR 抗体 (Ser 2481 55.42) 参考文献:

  1. 痤疮患者皮肤中雷帕霉素（mTOR）表达的机制靶点增加。  |  Monfrecola, G., et al. 2016. Exp Dermatol. 25: 153-5. PMID: 26477999
  2. 血管性痴呆大鼠海马CA1区雷帕霉素哺乳动物靶标（mTOR）和磷酸化-mTOR表达的时间变化  |  Park, JA. and Lee, CH. 2017. J Vet Sci. 18: 11-16. PMID: 27297423
  3. 磷酸化哺乳动物雷帕霉素靶蛋白（p-mTOR）是胃癌中比mTOR更有利的预后因子。  |  Cao, GD., et al. 2016. PLoS One. 11: e0168085. PMID: 28005970
  4. 卵泡和Hürthle细胞甲状腺肿瘤中磷酸化机制靶点（p-mTOR）和非编码RNA的表达。  |  Covach, A., et al. 2017. Endocr Pathol. 28: 207-212. PMID: 28660408
  5. 硫氧还蛋白-1在心肌细胞氧化应激过程中维持雷帕霉素机制靶标（mTOR）的功能  |  Oka, SI., et al. 2017. J Biol Chem. 292: 18988-19000. PMID: 28939765
  6. 雷帕霉素的机制靶点：整合生长因子和营养信号在集合管中的作用。  |  Brown, AL., et al. 2018. Am J Physiol Renal Physiol. 315: F413-F416. PMID: 29846113
  7. 雷帕霉素复合物1途径的机制靶标对转录和表观遗传的调控。  |  Laribee, RN. 2018. J Mol Biol. 430: 4874-4890. PMID: 30359581
  8. 雷帕霉素机制靶点信号在调节胎儿生长中的新作用†.  |  Gupta, MB. and Jansson, T. 2019. Biol Reprod. 100: 872-884. PMID: 30476008
  9. 蛋氨酸和精氨酸的供应改变了牛乳腺上皮细胞中机械靶向雷帕霉素（mTOR）、昼夜节律蛋白和α-s1-酪蛋白丰度的磷酸化。  |  Hu, L., et al. 2020. Food Funct. 11: 883-894. PMID: 31942894
  10. 犬皮肤肿瘤中磷酸化雷帕霉素机制靶标的组织学和免疫组织化学评估。  |  Mathew, R., et al. 2021. J Comp Pathol. 184: 60-64. PMID: 33894879

订购信息

产品名称产品编号规格价格数量收藏夹

p-mTOR 抗体 (Ser 2481 55.42)

sc-293089
200 µg/ml
RMB2377.00

p-mTOR (Ser 2481 55.42): m-IgG Fc BP-HRP 套装

sc-527318
200 µg Ab; 10 µg BP
RMB2662.00

p-mTOR (Ser 2481 55.42): m-IgG1 BP-HRP 套装

sc-532691
200 µg Ab; 20 µg BP
RMB2662.00

p-mTOR 抗体 (55.42) AC

sc-293089 AC
500 µg/ml, 25% ag
RMB3129.00

p-mTOR 抗体 (55.42) HRP

sc-293089 HRP
200 µg/ml
RMB2377.00

Can mTOR (55.42): sc-293089 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, mTOR (55.42): sc-293089 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-05-05

Saludos, quisiera saber específicamente contra qué región de la proteína de humanos se generó este anticuerpo. Gracias

Asked by: Kenia
Hola, gracias por tu pregunta. Este anticuerpo fue hecho contra un péptido sintético correspondiente a mTOR de origen humano. Hello, thank you for your question. This antibody was raised against a synthetic peptide corresponding to mTOR of human origin.
Answered by: Tech Service 3
Date published: 2017-05-05
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Rated 4 out of 5 by from Good for western blotWe used it to detect mTOR in several human cancer cell lines by western blot, and worked well at 1:500 dilution
Date published: 2023-07-17
Rated 5 out of 5 by from PII brought this weeks ago and i am very happy, customer is very good
Date published: 2019-05-03
Rated 5 out of 5 by from positiveI suggest dilution of antibody 1:200 and loading 20ug samples to analyze tissues in WB experiments. I see specific signals.
Date published: 2017-10-31
Rated 5 out of 5 by from Great featureI bought a month ago and I am very happy that the effect of feature is very good
Date published: 2017-10-30
Rated 4 out of 5 by from Good antibodyI used this antibody to test the changes in T cell acute lymphoblastic leukemia cells like jurkat，it is a Good antibody for WB
Date published: 2017-10-23
Rated 5 out of 5 by from mTOR antibodyThis antibody works well at 1:500 dilution. Not bad for WB.
Date published: 2017-10-07
Rated 5 out of 5 by from GreatI use it in IHC by diluted 1:50. I get a wonderful result.
Date published: 2017-10-05
Rated 3 out of 5 by from Good antibodyWorked well with western blotting at 1:500 dilution.
Date published: 2017-09-27
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p-mTOR 抗体 (Ser 2481 55.42) is rated 4.4 out of 5 by 30.
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