Date published: 2025-9-7

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p-c-Fos 抗体 (34E4): sc-81485

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说明书
  • p-c-Fos抗体(34E4)是小鼠单克隆IgG1 κ, 在35篇文献中引用,规格为50 µg/0.5 ml
  • 针对合成磷酸化肽的抗血清,针对c-Fos的human起源的丝氨酸374
  • 推荐用于 human 和 canine 来源的Ser 374 phosphorylated c-Fos WB 和 IP检测
  • 关于如何获取p-c-Fos (34E4): sc-81485免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是p-c-Fos Antibody (34E4) for WB applications. 的首选辅助检测试剂,这些试剂现与p-c-Fos Antibody (34E4) 打包提供(请参阅下面的订购信息)。

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関連項目

p-Fos/c-Fos抗体(34E4)是一种IgG1 κ小鼠单克隆p-c-Fos抗体(也称为p-c-Fos抗体),可通过WB和IP检测人源Ser 374磷酸化的c-Fos。p-Fos/c-Fos抗体(34E4)以非偶联抗p-c-Fos抗体形式提供。c-Fos癌基因最初在两种独立的小鼠骨肉瘤病毒分离株和一种禽类肾母细胞瘤病毒中被检测到。其细胞同源物c-Fos编码一种核磷蛋白,该蛋白可被多种因子迅速且瞬时诱导,并作为几个基因的转录调节因子。与形成同源二聚体和异源二聚体并与特定DNA反应元件结合的c-Jun蛋白不同,c-Fos蛋白仅在与Jun基因家族成员结合形成异源二聚体时才具有活性。c-Fos的功能同源物包括Fra-1、Fra-2和Fos B基因。此外,选定的ATF/CREB家族成员可以与Fos和Jun形成亮氨酸拉链二聚体。不同的二聚体对AP-1和CRE位点表现出不同的特异性和亲和力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-c-Fos 抗体 (34E4) 参考文献:

  1. 蛋白激酶D2能增强瑞士3T3细胞中由蚕豆素诱导的MEK/ERK/RSK信号传导, c-Fos积累和DNA合成。  |  Sinnett-Smith, J., et al. 2007. J Cell Physiol. 211: 781-90. PMID: 17226786
  2. 伊朗肝细胞癌中 p53, cyclinD1, RB1, c-fos 和 N-ras 基因表达的免疫组化分析。  |  Moghaddam, SJ., et al. 2007. World J Gastroenterol. 13: 588-93. PMID: 17278226
  3. 单磷酸环磷酸腺苷通过磷酸化 c-Fos 蛋白抑制促炎细胞因子的转录。  |  Koga, K., et al. 2009. Immunity. 30: 372-83. PMID: 19285436
  4. fos基因家族的另一成员fra-2的分离和特征描述。  |  Nishina, H., et al. 1990. Proc Natl Acad Sci U S A. 87: 3619-23. PMID: 2110368
  5. fos 相关基因的产物 fra-1 与 Jun 共同结合到 AP-1 位点:转录因子 AP-1 由多种蛋白质复合物组成。  |  Cohen, DR., et al. 1989. Genes Dev. 3: 173-84. PMID: 2497053
  6. 一种从肾母细胞瘤中分离出来的禽转化逆转录病毒,携带 fos 基因作为癌基因。  |  Nishizawa, M., et al. 1987. J Virol. 61: 3733-40. PMID: 2824811
  7. 人类原癌基因 c-jun 编码一种 DNA 结合蛋白,具有转录因子 AP-1 的结构和功能特性。  |  Bohmann, D., et al. 1987. Science. 238: 1386-92. PMID: 2825349
  8. c-fos 原癌基因产物的染色质关联和 DNA 结合特性。  |  Renz, M., et al. 1987. Nucleic Acids Res. 15: 277-92. PMID: 3103098
  9. Fos 蛋白复合物与离体细胞核中的 DNA 相关联,并与 DNA 纤维素结合。  |  Sambucetti, LC. and Curran, T. 1986. Science. 234: 1417-9. PMID: 3491427
  10. 病毒诱发小鼠骨肉瘤。  |  Finkel, MP., et al. 1966. Science. 151: 698-701. PMID: 5218049

订购信息

产品名称产品编号规格价格数量收藏夹

p-c-Fos 抗体 (34E4)

sc-81485
50 µg/0.5 ml
RMB2377.00

p-c-Fos (34E4): m-IgG Fc BP-HRP 套装

sc-539616
50 µg Ab; 10 µg BP
RMB2662.00

p-c-Fos (34E4): m-IgG1 BP-HRP 套装

sc-541602
50 µg Ab; 20 µg BP
RMB2662.00

As I understand c-Fos protein is 62 kDa, but your c-Fos antibody (sc-271243) shows abot 40 kDa band and this phosphorylated shows about 50 kDa band. Would you please explain why they are not 62. Thanks

Asked by: Dina
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2023-10-31

Can this antibody be used for detection of phosphorylated c-Fos of mouse origin?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Service 11
Date published: 2017-01-20
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Rated 5 out of 5 by from nice AbI've got this Ab as a free sample. Used it on lung cancer cells and got a nice result. Highly recommend to use the cells recommended by Santa Cruz as a "positive control", otherwise it's really hard to locate the protein in Western Blot. Nice Ab
Date published: 2017-12-07
Rated 5 out of 5 by from Great productVery clean western blot data; strong signal, low background
Date published: 2017-02-05
Rated 5 out of 5 by from Looking for an p-c-Fos antibody?Nice strong bands on Western blot. Would recommend for all your p-c-Fos detection needs.
Date published: 2016-12-22
Rated 5 out of 5 by from Recommend it for detecting the phosphorylatedRecommend it for detecting the phosphorylated form of the protein. -SCBT QC
Date published: 2015-03-19
Rated 5 out of 5 by from Excellent antibody for detecting phoshorylatedExcellent antibody for detecting phoshorylated proteins. Would highly recommend!
Date published: 2015-01-06
Rated 5 out of 5 by from Published with this antibody on human samplesPublished with this antibody on human samples. Great antibody for a great price! -SCBT Publication Review
Date published: 2014-06-18
Rated 5 out of 5 by from Great antibody for WBGreat antibody for WB! -SCBT QC
Date published: 2013-08-15
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p-c-Fos 抗体 (34E4) is rated 5.0 out of 5 by 7.
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