Date published: 2025-9-7

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MCM7 抗体 (0.N.194): sc-71550

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说明书
  • MCM7抗体(0.N.194)是小鼠单克隆IgG1 κ, 在3篇文献中引用,规格为200 µg/ml
  • 针对全长MCM7,human起源
  • 推荐用于 mouse, rat 和 human 来源的MCM7 WB, IP, IF 和 IHC(P)检测
  • 看 MCM7 (141.2): sc-9966,可查看有标记的 MCM7 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 MCM7 抗体 (0.N.194) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MCM7 抗体 (0.N.194) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

微染色体维持(MCM)蛋白家族,包括MCM2、MCM3、MCM4(Cdc21)、MCM5(Cdc46)、MCM6(Mis5)和MCM7(Cdc47),是DNA复制的调节因子,其作用在于确保复制在细胞周期中只发生一次。MCM蛋白的表达在细胞生长过程中增加,在G1至S期达到高峰。每个MCM蛋白都包含一个ATP结合基序,预计会介导ATP依赖性的双链DNA打开。MCM蛋白受E2F转录因子的调控,该因子可诱导MCM的表达,以及受蛋白激酶的调控,后者与MCM蛋白相互作用以维持细胞的复制后状态。MCM2/MCM4复合物在体外作为Cdc2/cyclin B的底物发挥作用。MCM3的裂解(可被caspase抑制剂阻止)会导致至少由MCM2-6组成的MCM复合物在凋亡期间失活。已显示由MCM4、MCM6和MCM7组成的复合物参与DNA解旋酶活性,而MCM5参与IFN-γ诱导的Stat1α转录激活。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCM7 抗体 (0.N.194) 参考文献:

  1. 最小染色体维持蛋白MCM7是神经母细胞瘤中MYCN转录因子的直接靶标。  |  Shohet, JM., et al. 2002. Cancer Res. 62: 1123-8. PMID: 11861392
  2. EZH2, Ki-67 和 MCM7 是前列腺切除术患者的预后指标。  |  Laitinen, S., et al. 2008. Int J Cancer. 122: 595-602. PMID: 17943722
  3. 细胞周期蛋白 A 通过与复制许可因子 Mcm7 相互作用,促进细胞进入 S 期。  |  Chibazakura, T., et al. 2011. Mol Cell Biol. 31: 248-55. PMID: 21078875
  4. 非小细胞肺癌(NSCLC)患者支气管刷状物中 MCM7 表达的预后意义。  |  Liu, YZ., et al. 2012. Lung Cancer. 77: 176-82. PMID: 22456526
  5. 小鼠胚胎 DNA 复制许可过程中 ORC2 和 MCM7 定位的独特模式  |  Ortega, MA., et al. 2012. Biol Reprod. 87: 62. PMID: 22674395
  6. 巨核细胞诱导多倍体过程中MCM7及其内含子miRNA群miR-106b-25的调控差异。  |  Haldar, S., et al. 2014. RNA Biol. 11: 1137-47. PMID: 25483046
  7. RNAi--mediated knockdown of MCM7 gene on CML cells and its therapeic potential for leukemia.  |  Tian, L., et al. 2017. Med Oncol. 34: 21. PMID: 28058629
  8. 中心体 MCM7 可加强 Cep68-VHL 的相互作用,过量的 MCM7 会导致 Cep68 泛素化和蛋白酶体降解增加,从而导致中心体分裂。  |  Kong, L., et al. 2017. Biochem Biophys Res Commun. 489: 497-502. PMID: 28578000
  9. 三氧化二砷通过靶向 SRF/MCM7 复合物抑制肝癌干细胞和转移。  |  Wang, HY., et al. 2019. Cell Death Dis. 10: 453. PMID: 31186405
  10. 更正为MCM7 通过依赖细胞周期蛋白 D1 的信号转导促进癌症进展,是肝细胞癌患者的预后标志物。  |  Qu, K., et al. 2022. Cell Death Dis. 13: 950. PMID: 36357373

订购信息

产品名称产品编号规格价格数量收藏夹

MCM7 抗体 (0.N.194)

sc-71550
200 µg/ml
RMB2377.00

MCM7 (0.N.194): m-IgG Fc BP-HRP 套装

sc-537202
200 µg Ab; 10 µg BP
RMB2662.00

MCM7 (0.N.194): m-IgGκ BP-HRP 套装

sc-534412
200 µg Ab; 40 µg BP
RMB2662.00

MCM7 (0.N.194): m-IgG1 BP-HRP 套装

sc-545075
200 µg Ab; 20 µg BP
RMB2662.00

What blocking solution should I use with MCM7 (0.N.194): sc-71550 monoclonal antibody for Western blot?

Asked by: Randy McDonald
Thank you for your question. We recommend blocking with Blotto (either TBS Blotto A: sc-2333 or TBS Blotto B: sc-2335). Our Western blot protocol can be found here: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-01
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Rated 4 out of 5 by from Robust bands observed in western blot analysisRobust bands observed in western blot analysis of MCM7 expression in non-transfected 293T, human MCM7 transfected 293T and A-431 whole cell lysates. -SCBT QC
Date published: 2015-02-19
Rated 4 out of 5 by from Slightly faint bands present in western blotSlightly faint bands present in western blot using COLO 320DM, H4 and HeLa whole cell lysates. -SCBT QC
Date published: 2014-08-05
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MCM7 抗体 (0.N.194) is rated 4.0 out of 5 by 2.
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