Date published: 2025-9-7

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MCM7 抗体 (141.2): sc-9966

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说明书
  • MCM7 抗体 141.2 是小鼠单克隆 IgG1 κ,MCM7抗体, 在195篇文献中引用,规格为200 µg/ml
  • 针对全长MCM7,human起源
  • MCM7 抗体 (141.2) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 MCM7
  • 抗MCM7抗体(141.2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MCM7 (141.2): sc-9966免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 MCM7 抗体 (141.2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MCM7 抗体 (141.2) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MCM7抗体(141.2)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学(IHC)和酶联免疫吸附测定(ELISA)等方法检测小鼠、大鼠和人源MCM7蛋白。MCM7单克隆抗体(141.2)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶、藻红蛋白、异硫氰酸荧光素和多种Alexa Fluor®结合物。小染色体维持(MCM)家族蛋白包括MCM2、MCM3、MCM4(Cdc21)、MCM5(Cdc46)、MCM6(Mis5)和MCM7(Cdc47),在调节DNA复制方面发挥着关键作用,确保细胞周期中仅发生一次复制。MCM7对于MCM2-7复合物的形成至关重要,该复合物作为解旋酶可解开DNA链,从而促进复制过程。MCM7的正常运作对于维持基因组稳定性至关重要,因为任何失调都可能导致细胞无序增殖并诱发肿瘤。MCM蛋白(包括MCM7)的表达在细胞生长过程中增加,在细胞周期从G1期过渡到S期时达到峰值,并受到E2F转录因子和各种蛋白激酶的严格调控。MCM7与其他MCM蛋白的相互作用,特别是在形成解旋酶复合物时,凸显了MCM7在DNA复制机制中的重要性,使MCM7 (141.2)抗体成为研究细胞周期动力学和DNA复制机制的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCM7 抗体 (141.2) 参考文献:

  1. MCM7 作为非功能性垂体腺瘤手术后进展的标志物。  |  Hallén, T., et al. 2021. Eur J Endocrinol. 184: 521-531. PMID: 33524001
  2. 氧化应激诱导的 circKIF18A 下调会损害 MCM7 在椎间盘退变中介导的抗衰老作用。  |  Wang, J., et al. 2022. Exp Mol Med. 54: 285-297. PMID: 35332256
  3. 磷脂酶 PLCE1 促进 MCM7 的转录和磷酸化,推动食管癌的肿瘤进展。  |  Shi, Q., et al. 2024. Cancer Res. 84: 560-576. PMID: 38117512
  4. 剪接因子 WBP11 介导 MCM7 内含子保留,促进卵巢癌的恶性进展。  |  Wei, Y., et al. 2024. Oncogene. 43: 1565-1578. PMID: 38561505
  5. 包括参与真核生物 DNA 复制起始过程的 MCM 蛋白在内的各种假定的依赖核酸的 ATP 酶中存在一组共同的保守基序。  |  Koonin, EV. 1993. Nucleic Acids Res. 21: 2541-7. PMID: 8332451
  6. DNA 螺旋酶的活性与 MCM4, -6 和 -7 蛋白复合物有关。  |  Ishimi, Y. 1997. J Biol Chem. 272: 24508-13. PMID: 9305914
  7. 在 G2 阶段抑制蛋白激酶可使哺乳动物的 Mcm 蛋白与染色质重新结合,恢复复制能力。  |  Coverley, D., et al. 1998. Exp Cell Res. 238: 63-9. PMID: 9457057
  8. 核复制因子 MCM3 在细胞凋亡过程中的选择性蛋白水解。  |  Schwab, BL., et al. 1998. Exp Cell Res. 238: 415-21. PMID: 9473350
  9. 细胞周期和染色质结合状态依赖的人类 MCM 异六聚体复合物磷酸化。cdc2 激酶的作用。  |  Fujita, M., et al. 1998. J Biol Chem. 273: 17095-101. PMID: 9642275
  10. E2F3 的活性在细胞周期中受到调控,是诱导 S 期所必需的。  |  Leone, G., et al. 1998. Genes Dev. 12: 2120-30. PMID: 9679057
  11. 在 IFN-gamma 诱导的转录激活过程中,Stat1alpha 对 MCM5 的招募依赖于 Ser727。  |  Zhang, JJ., et al. 1998. EMBO J. 17: 6963-71. PMID: 9843502
  12. 人类 T 细胞白血病病毒 1 型税蛋白可减轻小鼠 T 细胞系对白细胞介素-2 的依赖性。  |  Iwanaga, Y., et al. 1999. J Virol. 73: 1271-7. PMID: 9882331

订购信息

产品名称产品编号规格价格数量收藏夹

MCM7 抗体 (141.2)

sc-9966
200 µg/ml
RMB2377.00

MCM7 (141.2): m-IgG Fc BP-HRP 套装

sc-528241
200 µg Ab; 10 µg BP
RMB2662.00

MCM7 (141.2): m-IgGκ BP-HRP 套装

sc-520567
200 µg Ab, 40 µg BP
RMB2662.00

MCM7 (141.2): m-IgG1 BP-HRP 套装

sc-542832
200 µg Ab; 20 µg BP
RMB2662.00

MCM7 抗体 (141.2) AC

sc-9966 AC
500 µg/ml, 25% agarose
RMB3129.00

MCM7 抗体 (141.2) HRP

sc-9966 HRP
200 µg/ml
RMB2377.00

MCM7 抗体 (141.2) FITC

sc-9966 FITC
200 µg/ml
RMB2482.00

MCM7 抗体 (141.2) PE

sc-9966 PE
200 µg/ml
RMB2580.00

MCM7 抗体 (141.2) Alexa Fluor® 488

sc-9966 AF488
200 µg/ml
RMB2685.00

MCM7 抗体 (141.2) Alexa Fluor® 546

sc-9966 AF546
200 µg/ml
RMB2685.00

MCM7 抗体 (141.2) Alexa Fluor® 594

sc-9966 AF594
200 µg/ml
RMB2685.00

MCM7 抗体 (141.2) Alexa Fluor® 647

sc-9966 AF647
200 µg/ml
RMB2685.00

MCM7 抗体 (141.2) Alexa Fluor® 680

sc-9966 AF680
200 µg/ml
RMB2685.00

MCM7 抗体 (141.2) Alexa Fluor® 790

sc-9966 AF790
200 µg/ml
RMB2685.00

Is there any data showing MCM7 Antibody (141.2): sc-9966 is specific to MCM7?

Asked by: jenni
Thank you for your question. We have Western blot data showing HeLa cells treated with siRNA to show knockdown of signal, confirming specificity to MCM7.
Answered by: Technical Support 15
Date published: 2017-01-09
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Rated 5 out of 5 by from It works very nice in IHC.MCM7 antibody from SC is very good. We have used at 1:50 dilution and it works well in IHC.
Date published: 2024-10-12
Rated 5 out of 5 by from great antibody for WB and flowBought this antibody after trying a sample first. It works both for western blot (1:500) and for staining MCM7 on chromatin for flow cytometry (1:200). Very happy with this one.
Date published: 2022-10-23
Rated 5 out of 5 by from review for MCM7 ANTIBODYWe purchased this antibody, and it works well on our hand!
Date published: 2019-11-26
Rated 5 out of 5 by from Works PerfectI bought this antibody few weeks back and tried our HEK293 cell extract and I am totally satisfied with its detection capacity.
Date published: 2019-08-07
Rated 5 out of 5 by from great antibodyit's a good antibody for WB. there is a clear band with 1:2000 dilution
Date published: 2018-03-23
Rated 5 out of 5 by from good features基本没有杂带,牛奶 封闭,一抗 过夜 ,二抗牛奶室 温两小时,30ug细胞蛋白,跑出条带无 杂 带
Date published: 2018-03-11
Rated 5 out of 5 by from excellent antibodyI blotted the entire membrane (PVCF) with this antibody. MCM7 band is the only band I got. It is very strong.
Date published: 2017-12-01
Rated 5 out of 5 by from a fantastic antibody for WBThis antibody generates a clear and strong signal at the predicted position on the WB (1:500 dilution, 40ug HeLa extract).
Date published: 2017-09-18
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MCM7 抗体 (141.2) is rated 5.0 out of 5 by 17.
  • y_2025, m_9, d_6, h_5
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