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MAP-2 Antibody (AP20) - Immunohistochemistry - Image 156735
MAP-2 抗体 (AP20): sc-32791. 对福尔马林固定, 石蜡包埋的人脑组织进行免疫过氧化物酶染色, 显示神经元细胞的神经髓和细胞质染色.
MAP-2 抗体 (AP20): sc-32791. 对福尔马林固定, 石蜡包埋的人脑组织进行免疫过氧化物酶染色, 显示神经元细胞的神经髓和细胞质染色.

MAP-2 抗体 (AP20): sc-32791

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说明书
  • MAP-2抗体(AP20)是小鼠单克隆IgG1 κ, 在48篇文献中引用，规格为200 µg/ml
  • 针对bovine起源的MAP-2，抗原表位与氨基酸997-1332对应
  • MAP-2 抗体 (AP20) 推荐用于WB, IP, IF 和 IHC(P) ，检测 mouse, rat, human 和 Xenopus来源的MAP-2A and MAP-2B; 也和以下物种反应，包括： bovine; 不会与 MAP-2C, MAP-1, MAP-5, Tubulin or Tau产生交联反应
  • 抗MAP-2抗体（AP20）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 目前，我们还没有完成MAP-2 抗体 (AP20)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

额外MAP抗体，包括MAP-1B, MAP-2, MAP-4, MAP-6D1和MAP-1S

MAP-2抗体（AP20）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学等方法检测小鼠、大鼠和人类样本中的MAP-2。抗MAP-2抗体（AP20）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。MAP-2在稳定和组织微管方面起着至关重要的作用，而微管是细胞骨架的重要组成部分。MAP-2通过与微管结合，增强稳定性并促进微管蛋白的组装，从而影响微管在细胞内的分布。这一功能可维持细胞结构并促进细胞内运输。MAP-2可调节微管的动态变化，而磷酸化状态则显著影响其功能和蛋白质相互作用。了解MAP-2在微管动态变化中的作用有助于解释其对神经元发育和功能的影响，以及微管稳定性受损对神经退行性疾病的影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MAP-2 抗体 (AP20) 参考文献:

  1. 微管相关蛋白2（MAP-2）在神经元生长、可塑性和变性中的作用。  |  Johnson, GV. and Jope, RS. 1992. J Neurosci Res. 33: 505-12. PMID: 1484385
  2. MAP-2在人类腺垂体和垂体腺瘤中的表达。一项免疫组织化学研究。  |  Rotondo, F., et al. 2005. Pituitary. 8: 75-9. PMID: 16195780
  3. 微管相关蛋白-2（MAP-2）免疫组化在石蜡包埋直肠抽吸活检中识别神经节细胞的实用性。  |  Burtelow, MA. and Longacre, TA. 2009. Am J Surg Pathol. 33: 1025-30. PMID: 19363440
  4. MAP-2通过微管形成而过度表达，在癫痫大鼠的苔藓状纤维萌发中起着重要作用。  |  Tang, L., et al. 2014. J Mol Neurosci. 53: 103-8. PMID: 24390958
  5. MAP-2和tau在体外脑微管上的结合：对微管结构的影响。  |  Kim, H., et al. 1986. Ann N Y Acad Sci. 466: 218-39. PMID: 3089106
  6. MAP-2 微管结合域的分析。  |  Gottlieb, RA. and Murphy, DB. 1985. J Cell Biol. 101: 1782-9. PMID: 4055896
  7. 人类微管相关蛋白2（MAP-2）的基因组结构以及MAP-2其他同工型的特征。  |  Kalcheva, N., et al. 1995. Proc Natl Acad Sci U S A. 92: 10894-8. PMID: 7479905
  8. MAP-2微管结合区与微管的非合作性结合。  |  Coffey, RL. and Purich, DL. 1995. J Biol Chem. 270: 1035-40. PMID: 7836356
  9. NMDA受体的激活介导了氨的毒性，以及氨对微管相关蛋白MAP-2的影响。  |  Felipo, V., et al. 1993. Adv Exp Med Biol. 341: 83-93. PMID: 8116489
  10. 了解多种MAP-2转录本及其在神经元中的作用。  |  Shafit-Zagardo, B. and Kalcheva, N. 1998. Mol Neurobiol. 16: 149-62. PMID: 9588626

订购信息

产品名称产品编号规格价格数量收藏夹

MAP-2 抗体 (AP20)

sc-32791
200 µg/ml
CNY2422.00

MAP-2 抗体 (AP20) AC

sc-32791 AC
500 µg/ml, 25% agarose
CNY3189.00

MAP-2 抗体 (AP20) HRP

sc-32791 HRP
200 µg/ml
CNY2422.00

MAP-2 抗体 (AP20) FITC

sc-32791 FITC
200 µg/ml
CNY2527.00

MAP-2 抗体 (AP20) PE

sc-32791 PE
200 µg/ml
CNY2625.00

MAP-2 抗体 (AP20) Alexa Fluor® 488

sc-32791 AF488
200 µg/ml
CNY2738.00

MAP-2 抗体 (AP20) Alexa Fluor® 546

sc-32791 AF546
200 µg/ml
CNY2738.00

MAP-2 抗体 (AP20) Alexa Fluor® 594

sc-32791 AF594
200 µg/ml
CNY2738.00

MAP-2 抗体 (AP20) Alexa Fluor® 647

sc-32791 AF647
200 µg/ml
CNY2738.00

MAP-2 抗体 (AP20) Alexa Fluor® 680

sc-32791 AF680
200 µg/ml
CNY2738.00

MAP-2 抗体 (AP20) Alexa Fluor® 790

sc-32791 AF790
200 µg/ml
CNY2738.00

I need a Map2 antibody for identify mature neurons that not have unspecific labeling in human fibroblast. Which of two Map2 antibodies do you recommend me?

Asked by: Clotilde
Thank you for your question. All our MAP-2 antibodies are human reactive and will detect MAP-2 in your human samples. I would suggest either sc-74421 or sc-32791, both are very specific and strong MAP-2 antibodies.
Answered by: Tech Service
Date published: 2019-10-08

I need to use an antibody to detect the protein in samples of canine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 15
Date published: 2017-01-20
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Rated 4 out of 5 by Tanusree from Good antibodyThis antibody worked very well with fixed frozen mouse tissue sections for IF
Date published: 2018-10-03
Rated 5 out of 5 by mingtsai from Good for IFThis MAP-2 Antibody (AP20) shows strong specific signal in IF staining in primary rat motor neuron.
Date published: 2018-02-20
Rated 5 out of 5 by Anonymous from Review of MAP-2MAP-2 (1:200) was used for immunocytochemistry in primary mouse neurons. very good images with confocal
Date published: 2018-01-29
Rated 5 out of 5 by kcievin from is goodVery strong robust bands observed by Western Blot using IMR-32 whole cell lysates.
Date published: 2017-02-12
Rated 5 out of 5 by Bill28 from Great productStrong antibody for WB,IF and IHC staining applications
Date published: 2017-02-05
Rated 5 out of 5 by TinTin from Really nice IHC staining!Map-2 (AP20) is a perfect choice if you're looking for a MAP-2 antibody for IHC or Western blotting. Reliable and strong, a solid clone.
Date published: 2016-12-30
Rated 5 out of 5 by ET from Superb immunoperoxidase neuropil and cytoplasmicSuperb immunoperoxidase neuropil and cytoplasmic staining in formalin fixed, paraffin-embedded human brain tissue. -SCBT QC
Date published: 2015-05-03
Rated 5 out of 5 by MS from Robust signal in WB in IMRRobust signal in WB in IMR-32 whole cell lysate. -SCBT QC
Date published: 2015-01-28
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MAP-2 抗体 (AP20) is rated 4.9 out of 5 by 8.
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