Date published: 2025-9-6

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Integrin αX/ITGAX/CD11c 抗体 (D-8): sc-398708

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说明书
  • Integrin αX/ITGAX/CD11c抗体(D-8)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于mouse物种的Integrin αX的内部区域内的氨基酸117-154之间
  • 抗-Integrin αX/ITGAX/CD11c 抗体 (D-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse 和rat 来源的 Integrin αX
  • 抗Integrin αX/ITGAX/CD11c抗体(D-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin αX/ITGAX/CD11c (D-8): sc-398708免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Integrin αX/ITGAX/CD11c 抗体 (D-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Integrin αX/ITGAX/CD11c 抗体 (D-8) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

Integrin αX/ITGAX/CD11c抗体(D-8)是一种IgG1κ小鼠单克隆Integrin αX抗体,可通过WB、IP、IF、IHC(P)和ELISA检测小鼠和大鼠来源的Integrin αX。Integrin αX/ITGAX/CD11c抗体(D-8)既可作为非偶联的抗Integrin αX抗体形式提供,也可作为多种偶联形式的抗Integrin αX抗体提供,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Integrin αX(CD11C、白细胞表面抗原p150,95、CR4、Axb2)是一种1型跨膜蛋白,传统上与β2链结合形成白细胞特异性整合素,称为非活化C3b(iC3b)受体4(CR4)。Integrin αX/β2在介导中性粒细胞和单核细胞粘附于受刺激的内皮细胞以及吞噬补体包被颗粒方面与αM/β2整合素具有相似的特性。Integrin αX的异常表达是毛细胞白血病(HCL)的特征,并依赖于原癌基因Ras和JunD的激活。影响Integrin αX转录的蛋白质和DNA元素包括Sp1和Sp1样因子、AP-1家族、C/EBP、Oct-2和PU.1。Integrin αX存在于单核细胞衍生的树突状细胞(DCs)、巨噬细胞和NK细胞上。激活后,存在于皮肤(朗格汉斯细胞)、鼻、肺、胃、肠和血液中的树突状细胞可以迁移到淋巴组织,并与T细胞和B细胞相互作用,从而启动和塑造免疫反应。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin αX/ITGAX/CD11c 抗体 (D-8) 参考文献:

  1. CD11c阳性慢性淋巴细胞白血病。  |  Tassies, D., et al. 1991. Blood. 78: 1893. PMID: 1680496
  2. 全髋关节置换术后假体周围组织中CD11c的表达。  |  Chamaon, K., et al. 2016. J Biomed Mater Res A. 104: 136-44. PMID: 26255872
  3. 前沿:自身免疫性糖尿病小鼠发炎胰岛中CD11c+细胞的起源、募集和调节。  |  Klementowicz, JE., et al. 2017. J Immunol. 199: 27-32. PMID: 28550204
  4. 肾浸润性CD11c+细胞通过促进CD4+ T细胞反应,在鼠狼疮性肾炎中起致病作用。  |  Liao, X., et al. 2017. Clin Exp Immunol. 190: 187-200. PMID: 28722110
  5. 肝内B220+CD11c+NK1.1+细胞调节肺转移前微环境形成。  |  Hiratsuka, S., et al. 2018. EMBO Mol Med. 10: PMID: 29930175
  6. 结肠直肠癌小鼠模型中淋巴器官中CD8+ CD11c+ T细胞频率的改变和免疫抑制分子的表达。  |  Rostamzadeh, D., et al. 2019. J Cell Physiol. 234: 11986-11998. PMID: 30623416
  7. 上皮V样抗原调节CD11c+ B细胞的扩增和抗病毒免疫。  |  Dungan, M. and Carrithers, MD. 2020. Immunobiology. 225: 151883. PMID: 31818507
  8. CD11c+ B细胞主要是健康供体中的记忆细胞和抗体分泌细胞的前体。  |  Golinski, ML., et al. 2020. Front Immunol. 11: 32. PMID: 32158442
  9. 未成熟的髓样CD11c+树突状细胞来源的破骨细胞前体对TRAF6缺失嵌合体内炎症引起的骨丢失的潜在贡献。  |  Liu, YCG. and Teng, AY. 2023. J Dent Sci. 18: 1372-1377. PMID: 37404624
  10. PU.1通过识别主要转录起始位点,负调控CD11c整合素基因启动子。  |  López-Rodríguez, C. and Corbí, AL. 1997. Eur J Immunol. 27: 1843-7. PMID: 9295016

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αX/ITGAX/CD11c 抗体 (D-8)

sc-398708
200 µg/ml
RMB2377.00

Integrin αX/ITGAX/CD11c (D-8): m-IgG Fc BP-HRP 套装

sc-527802
200 µg Ab; 10 µg BP
RMB2662.00

Integrin αX/ITGAX/CD11c (D-8): m-IgG1 BP-HRP 套装

sc-533175
200 µg Ab; 20 µg BP
RMB2662.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) AC

sc-398708 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) HRP

sc-398708 HRP
200 µg/ml
RMB2377.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) FITC

sc-398708 FITC
200 µg/ml
RMB2482.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) PE

sc-398708 PE
200 µg/ml
RMB2580.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 488

sc-398708 AF488
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 546

sc-398708 AF546
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 594

sc-398708 AF594
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 647

sc-398708 AF647
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 680

sc-398708 AF680
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (D-8) Alexa Fluor® 790

sc-398708 AF790
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c (D-8) 中和勝肽

sc-398708 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-398708 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 3 out of 5 by from Segnale medioHo testato questo anticorpo in Western Blot 1:100 in latte su campioni di lisati di tessuto cerebrale e tessuto intestinale di topo. E' uscito solo nei campioni di lisato intestinale (40 ug) sviluppando con anticorpi secondari HRP e reagente potenziato (Femto, Thermo Fisher) poco sopra la banda dei 150 kDa ed è abbastanza pulito. Tuttavia non è uscito nei campioni di lisato intestinale 20 ug.
Date published: 2024-02-08
Rated 4 out of 5 by from Good antibodyOur western blot results showed that this is a good antibody and it only had one specific band.
Date published: 2017-12-05
Rated 5 out of 5 by from Great specificityI got the sample 2 days ago,use it for IHC,the result is good.
Date published: 2017-07-20
Rated 5 out of 5 by from Excellent signal in Integrin αX我在两个月前申请了Integrin αX的抗体小样,并对收集的A549肿瘤进行了肿瘤免疫组化实验,实验结果很好,各组差异明显。
Date published: 2017-07-10
Rated 4 out of 5 by from Good specificity and signal strength forGood specificity and signal strength for WB in mouse Integrin X transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-18
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Integrin αX/ITGAX/CD11c 抗体 (D-8) is rated 4.2 out of 5 by 5.
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