Date published: 2025-9-6
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Integrin αX/ITGAX/CD11c Antibody (B-6) - Western Blotting - Image 63029
Integrin αX (B-6): sc-46676. 未转染 293T: sc-117752 (A), 转染人 Integrin αX 的 293T: sc-159744 (B) 和 HL-60 (C) 全细胞裂解液中 Integrin αX 表达的 Western 印迹分析.
Integrin αX (B-6): sc-46676. 未转染 293T: sc-117752 (A), 转染人 Integrin αX 的 293T: sc-159744 (B) 和 HL-60 (C) 全细胞裂解液中 Integrin αX 表达的 Western 印迹分析.

Integrin αX/ITGAX/CD11c 抗体 (B-6): sc-46676

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说明书
  • Integrin αX/ITGAX/CD11c抗体(B-6)是小鼠单克隆IgG1 κ, 在8篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Integrin αX的氨基酸613-680
  • Integrin αX/ITGAX/CD11c 抗体 (B-6) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 Integrin αX
  • 抗Integrin αX/ITGAX/CD11c抗体（B-6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin αX/ITGAX/CD11c (B-6): sc-46676的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Integrin αX/ITGAX/CD11c 抗体 (B-6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Integrin αX/ITGAX/CD11c 抗体 (B-6) 组合成套装提供。 (请参阅下面的订购信息)。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin αX 抗体（B-6）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）检测人源 Integrin αX。抗整合素αX抗体（B-6）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。整合素αX（Integrin αX）也称为CD11c，是一种1型跨膜蛋白，通过与β2链结合形成白细胞特异性整合素，在免疫系统中发挥关键作用，β2链被称为失活C3b受体4（CR4）。这种整合素对于介导中性粒细胞和单核细胞与活化内皮细胞的粘附以及促进对补体包被颗粒的吞噬至关重要，而吞噬对清除病原体和启动免疫反应至关重要。Integrin αX的异常表达与毛细胞白血病密切相关，凸显了其在癌症生物学和免疫调节中的重要性。Integrin αX的转录受多种蛋白质和DNA元件的影响，包括Sp1、AP-1家族成员和PU.1，这凸显了免疫细胞调节的复杂性。整合素αX主要表达于单核细胞衍生的树突状细胞、巨噬细胞和自然杀伤细胞，激活后，位于皮肤、肺和胃肠道等组织中的树突状细胞可迁移到淋巴器官，与T细胞和B细胞相互作用，协调适应性免疫反应。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin αX/ITGAX/CD11c 抗体 (B-6) 参考文献:

  1. 纤维蛋白原与 CD11c（p150,95 的α亚基）结构域结合的特征。  |  Nham, SU. 1999. Biochem Biophys Res Commun. 264: 630-4. PMID: 10543983
  2. 前沿：热休克蛋白 gp96 可诱导 CD11c+ 细胞在体内成熟和迁移。  |  Binder, RJ., et al. 2000. J Immunol. 165: 6029-35. PMID: 11086034
  3. 人脐静脉内皮细胞在体外表达补体受体 1（CD35）和补体受体 4（CD11c/CD18）。  |  Langeggen, H., et al. 2002. Inflammation. 26: 103-10. PMID: 12083416
  4. 毛细胞白血病中 CD11c 基因的表达依赖于原癌基因 ras 和 junD 的激活。  |  Nicolaou, F., et al. 2003. Blood. 101: 4033-41. PMID: 12576324
  5. 基线基因表达模式揭示的小鼠 CD11c（高）树突状细胞亚群之间的关系。  |  Edwards, AD., et al. 2003. J Immunol. 171: 47-60. PMID: 12816982
  6. 雌激素能优先促进骨髓前体中 CD11c+ CD11b（中间型）树突状细胞的分化。  |  Paharkova-Vatchkova, V., et al. 2004. J Immunol. 172: 1426-36. PMID: 14734718
  7. CD11c+树突状细胞是小鼠多微生物败血症存活的必要条件。  |  Scumpia, PO., et al. 2005. J Immunol. 175: 3282-6. PMID: 16116220
  8. 口腔沙门氏菌感染过程中树突状细胞和 CD11c(int)CD11b+ 细胞的成熟依赖于 TNF-α，也不依赖于 TNF-α。  |  Sundquist, M. and Wick, MJ. 2005. J Immunol. 175: 3287-98. PMID: 16116221
  9. 小肠中CD11c+ CX3CR1+细胞的分化需要Notch信号。  |  Ishifune, C., et al. 2014. Proc Natl Acad Sci U S A. 111: 5986-91. PMID: 24711412
  10. 循环中的经典单核细胞与人体内脏脂肪组织中的CD11c+巨噬细胞有关。  |  Wouters, K., et al. 2017. Sci Rep. 7: 42665. PMID: 28198418
  11. 系统性自身免疫和控制中CD11c+ B细胞的深度表型。  |  Rincon-Arevalo, H., et al. 2021. Front Immunol. 12: 635615. PMID: 33777025
  12. 腺苷受体2a激动剂可作用于感染和自身免疫中的小鼠CD11c+T-bet+ B细胞。  |  Levack, RC., et al. 2022. Nat Commun. 13: 452. PMID: 35064115

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αX/ITGAX/CD11c 抗体 (B-6)

sc-46676
200 µg/ml
RMB2377.00

Integrin αX/ITGAX/CD11c (B-6): m-IgG Fc BP-HRP 套装

sc-526721
200 µg Ab; 10 µg BP
RMB2662.00

Integrin αX/ITGAX/CD11c (B-6): m-IgG1 BP-HRP 套装

sc-532094
200 µg Ab; 20 µg BP
RMB2662.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) AC

sc-46676 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) HRP

sc-46676 HRP
200 µg/ml
RMB2377.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) FITC

sc-46676 FITC
200 µg/ml
RMB2482.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) PE

sc-46676 PE
200 µg/ml
RMB2580.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 488

sc-46676 AF488
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 546

sc-46676 AF546
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 594

sc-46676 AF594
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 647

sc-46676 AF647
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 680

sc-46676 AF680
200 µg/ml
RMB2685.00

Integrin αX/ITGAX/CD11c 抗体 (B-6) Alexa Fluor® 790

sc-46676 AF790
200 µg/ml
RMB2685.00

Can Integrin αX (B-6): sc-46676 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin αX (B-6): sc-46676 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2024-07-17
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Rated 4 out of 5 by from Buon funzionamentotestato su tonsilla umana alla condizione di 1:50 ph6 e performa molto bene
Date published: 2022-06-08
Rated 5 out of 5 by from Great signals on aorta from mouse tissuesI tried 1:50 dilution and it worked beautifully. Highly recommended.
Date published: 2018-05-21
Rated 5 out of 5 by from Good stainingNo problem on human brain IHC, pH 9 demasking, 1:50 dilution.
Date published: 2017-11-08
Rated 5 out of 5 by from Produced publishable WB & IHC data on humanThis Integrin αX Antibody was featured in the primary literature for use in WB on human monocytes and for use in IHC on human core cancer tissues.
Date published: 2017-01-18
Rated 4 out of 5 by from Nice IF stainingShowing nice membrane staining in THP-1 cells, when it was applied in IF. The only complaint is dilution, at 1:50, relatively lower than other antibody we purchased for ITGAX.
Date published: 2016-12-25
Rated 4 out of 5 by from low signal with IHC-PWe could only see low signal when doing IHC-P with this antibody in decidua tissue.
Date published: 2016-12-04
Rated 5 out of 5 by from Western blot analysis of Integrin X expressionWestern blot analysis of Integrin X expression in non-transfected 293T, human Integrin X transfected 293T and HL-60 whole cell lysates. -SCBT QC
Date published: 2015-04-08
Rated 5 out of 5 by from Western blot analysis of Integrin X expressionWestern blot analysis of Integrin X expression in AML-193 whole cell lysate. -SCBT QC
Date published: 2015-04-08
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Integrin αX/ITGAX/CD11c 抗体 (B-6) is rated 4.7 out of 5 by 9.
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