Date published: 2025-9-6

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Integrin α7/ITGA7 抗体 (012-Z): sc-81807

3.5(4)
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说明书
  • Integrin α7/ITGA7抗体(012-Z)是小鼠单克隆IgG2a κ, 在5篇文献中引用,规格为100 µg/ml
  • 针对部分重组蛋白Integrin α7(源自human)
  • 推荐用于 mouse, rat 和 human 来源的Integrin α7 WB, IP 和 ELISA检测
  • 关于如何获取Integrin α7/ITGA7 (012-Z): sc-81807免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Integrin α7/ITGA7 抗体 (012-Z)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Integrin α7抗体(012-Z)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类样本中的Integrin α7。Anti-Integrin α7抗体(012-Z)以非结合形式提供,可在各种实验设置中灵活应用。整合素α7是整合素家族的重要组成部分,该家族由非共价结合的跨膜α和β亚基形成的异二聚体组成。整合素α7单克隆抗体(012-Z)可识别一种在肌肉组织中特别重要的蛋白质,整合素α7在肌肉发育和修复中起着至关重要的作用,可调节细胞粘附和信号传导通路。Integrin α7与细胞外基质的成分相互作用,例如层粘连蛋白,后者对于维持肌纤维的结构完整性至关重要。这种相互作用不仅有助于细胞粘附,而且还能触发细胞内信号级联反应,从而促进肌肉细胞的存活、分化和迁移。了解Integrin α7的功能对于阐明肌肉疾病和损伤的机制非常重要,这使得Integrin α7 (012-Z)抗体成为研究肌肉生物学和相关病理学的研究人员的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α7/ITGA7 抗体 (012-Z) 参考文献:

  1. 整合素:细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  2. 局部前列腺癌中α;5-整合素、α;7-整合素、ε-cadherin 和 N-cadherin的表达。  |  Drivalos, A., et al. 2016. Urol Oncol. 34: 165.e11-8. PMID: 26652134
  3. 整合素α7是胶质母细胞瘤的功能标记和潜在治疗靶点  |  Haas, TL., et al. 2017. Cell Stem Cell. 21: 35-50.e9. PMID: 28602620
  4. Integrin α7:胶质母细胞瘤恶性肿瘤的主要驱动因素和治疗靶点。  |  Nunes, AM., et al. 2017. Stem Cell Investig. 4: 97. PMID: 29359136
  5. 整合素-α7信号调节连接蛋白43、M-粘连蛋白和肌母细胞融合  |  McClure, MJ., et al. 2019. Am J Physiol Cell Physiol. 316: C876-C887. PMID: 30892939
  6. 敲除 Integrin α7 可抑制肝细胞癌细胞的增殖, 迁移, 侵袭和 EMT。  |  Wu, Z., et al. 2021. Exp Ther Med. 21: 309. PMID: 33717252
  7. Integrin α7 基因突变与人类和小鼠成年后心脏功能障碍有关。  |  Bugiardini, E., et al. 2022. J Am Heart Assoc. 11: e026494. PMID: 36444867
  8. AGGF1疗法通过增强整合素α7介导的TGF-β1成熟和ERK1/2信号传导抑制胸主动脉瘤。  |  Da, X., et al. 2023. Nat Commun. 14: 2265. PMID: 37081014
  9. 整合素和信号转导途径:走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α7/ITGA7 抗体 (012-Z)

sc-81807
100 µg/ml
RMB2504.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Integrin α7 (012-Z): sc-81807 antibody?

Asked by: jerojero
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 1 out of 5 by from GoodI got the sample of this antibody to detect integrin a7 in heart lysates by Western Blot. It worked but there were also many nonspecific bands.
Date published: 2017-11-27
Rated 5 out of 5 by from Great Antibody for WBThis antibody is well-cited for a variety of applications including WB, IP, and ELISA. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-20
Rated 4 out of 5 by from Detected Integrin 7 expression in JurkatDetected Integrin 7 expression in Jurkat whole cell lysate. -SCBT QC
Date published: 2014-02-04
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Integrin α7/ITGA7 抗体 (012-Z) is rated 3.5 out of 5 by 4.
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