Date published: 2026-10-20

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Integrin α5/ITGA5/CD49e Antibody (MFR5/5H10) - Flow Cytometry - Image 9803
Integrin α5 (MFR5/5H10) PE: sc-23941 PE. IL-6 刺激 NIH/3T3 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常大鼠 IgG2a: sc-2872.
Integrin α5/ITGA5/CD49e Antibody (MFR5/5H10) - Flow Cytometry - Image 9803
Integrin α5 (MFR5/5H10) PE: sc-23941 PE. IL-6 刺激 NIH/3T3 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常大鼠 IgG2a: sc-2872.
Integrin α5/ITGA5/CD49e Antibody (MFR5/5H10) - Immunofluorescence - Image 10174
Integrin α5 (MFR5/5H10): sc-23941. 甲醇固定的 NIH/3T3 细胞免疫荧光染色显示膜定位.
Integrin α5 (MFR5/5H10) PE: sc-23941 PE. IL-6 刺激 NIH/3T3 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常大鼠 IgG2a: sc-2872.

Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10): sc-23941

4.3(4)
寫評論提問
说明书
  • Integrin α5/ITGA5/CD49e 抗体 MFR5/5H10 是大鼠单克隆 IgG2a, 在1篇文献中引用，提供 200 µg/ml
  • 对活化的 C57BL/6 mouse 脾细胞有抗性
  • 推荐用于 mouse, rat 和 human 来源的Integrin α5 IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前，我们还没有完成Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

整合素α5抗体（MFR5/5H10）是一种鼠单克隆IgG2a抗体，可通过免疫荧光（IF）和流式细胞术（FCM）检测小鼠、大鼠和人类样本中的整合素α5。整合素α5是整合素家族的重要组成部分，主要作为纤维粘连蛋白（一种重要的细胞外基质蛋白）的受体发挥作用。这种相互作用对于各种细胞过程至关重要，包括粘附、迁移和分化，因为它有助于细胞与其周围环境之间的沟通。抗整合素α5抗体（MFR5/5H10）能够检测细胞表面的整合素α5，使细胞能够对纤维蛋白原作出反应，促进细胞附着和扩散--这是组织发育和修复过程中的重要过程。整合素α5在调节细胞行为的信号通路中发挥着重要作用，影响伤口愈合和免疫反应等过程。整合素α5单克隆抗体（MFR5/5H10）有助于研究人员深入了解细胞粘附动力学和各种生理和病理状况的潜在机制，使其成为细胞生物学和组织工程研究中宝贵的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10) 参考文献:

  1. KGF通过CCAAT/增强子结合蛋白-β促进整合素α5的表达。  |  Koria, P. and Andreadis, ST. 2007. Am J Physiol Cell Physiol. 293: C1020-31. PMID: 17596295
  2. 整合素α5介导表皮生长因子诱导的视网膜色素上皮细胞增殖和迁移。  |  Chen, Z., et al. 2010. Pathobiology. 77: 88-95. PMID: 20332668
  3. AKR1B10通过整合素α5/δ-catenin介导的FAK/Src/Rac1信号通路促进乳腺癌转移。  |  Huang, C., et al. 2016. Oncotarget. 7: 43779-43791. PMID: 27248472
  4. 整合素α5和PDE4D之间的相互作用调节内皮炎症信号。  |  Yun, S., et al. 2016. Nat Cell Biol. 18: 1043-53. PMID: 27595237
  5. 整合素α5/ITGA5通过上皮-间质转化促进口腔鳞状细胞癌的增殖、迁移、侵袭和进展  |  Deng, Y., et al. 2019. Cancer Manag Res. 11: 9609-9620. PMID: 32009816
  6. 整合素α5通过抑制磷酸化ERK/caspase-3诱导的细胞凋亡介导三维鼻咽癌球体内顺铂的内在耐药性  |  Ngaokrajang, U., et al. 2021. Exp Cell Res. 406: 112765. PMID: 34358523
  7. 纤维连接蛋白和整合素α5在调节咽内胚层和软骨发育中发挥重叠和独立的作用。  |  Gao, Y., et al. 2022. Dev Biol. 489: 122-133. PMID: 35732225
  8. 成骨细胞通过激活整合素α5调节雄性小鼠对机械负荷的骨合成代谢反应。  |  Zhao, D., et al. 2022. Bone Res. 10: 49. PMID: 35851577
  9. 通过抑制整合素α5/β1-FAK/Src轴，用同型哈灵顿抑制膀胱癌的生长：一种新的药物应用策略。  |  Wu, Q., et al. 2023. Pharmacol Res. 188: 106654. PMID: 36640858
  10. 虾青素通过抑制幽门螺杆菌刺激胃上皮细胞中JAK1/STAT3的激活来抑制整合素α5的表达。  |  Woo, J., et al. 2023. Mol Med Rep. 27: PMID: 37203390

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10)

sc-23941
200 µg/ml
CNY2422.00

Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10) FITC

sc-23941 FITC
200 µg/ml
CNY2527.00

Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10) PE

sc-23941 PE
200 µg/ml
CNY2625.00

How can Integrin α5 (MFR5/5H10): sc-23941 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: cjMara
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-23941 PE) or fluoroscein (sc-23941 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by Ling C from Positive resultsWe had been used a5 antibodies from another source before but noticed the results are not consistent, varying with batches of antibodies. This antibody works great on human kidney tissues. The IHC results look identical as another α5 antibody (P1D6): sc-13547.
Date published: 2017-06-06
Rated 4 out of 5 by AB from Immunofluorescence staining of methanolImmunofluorescence staining of methanol-fixed NIH/3T3 cells shows membrane localization. -SCBT QC
Date published: 2015-03-29
Rated 4 out of 5 by SF from Published human WB resultsPublished human WB results. -SCBT Publication Review
Date published: 2015-02-07
Rated 4 out of 5 by TS from Positive staining of ILPositive staining of IL-6 stimulated NIH/3T3 cells in FCM. -SCBT QC
Date published: 2013-05-28
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Integrin α5/ITGA5/CD49e 抗体 (MFR5/5H10) is rated 4.3 out of 5 by 4.
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