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Integrin α5/ITGA5/CD49e Antibody (P1D6) - Flow Cytometry - Image 6053
Integrin α5 (P1D6) PE: sc-13547 PE. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG3: sc-2869.
Integrin α5 (P1D6) PE: sc-13547 PE. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG3: sc-2869.

Integrin α5/ITGA5/CD49e 抗体 (P1D6): sc-13547

5.0(4)
寫評論提問

说明书
  • Integrin α5/ITGA5/CD49e抗体(P1D6)是小鼠单克隆IgG3 κ, 在16篇文献中引用，规格为200 µg/ml
  • 针对淋巴因子活化杀伤细胞
  • 推荐用于 human 和 primate 来源的Integrin α5 WB, IP, IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 Integrin α5/ITGA5/CD49e (C-9): sc-376199，可查看有标记的 Integrin α5/ITGA5/CD49e 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取Integrin α5/ITGA5/CD49e (P1D6): sc-13547的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP 是Integrin α5/ITGA5/CD49e 抗体 (P1D6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Integrin α5/ITGA5/CD49e 抗体 (P1D6) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin α5 抗体（P1D6）是一种小鼠单克隆 IgG3 kappa 轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测人类和灵长类动物的 Integrin α5。抗整合素α5抗体（P1D6）有结合和非结合两种形式，可满足各种实验需求。整合素α5是整合素家族的重要组成部分，该家族由非共价结合的跨膜α和β亚基组成的异二聚体组成。Integrin α5 (P1D6) 单克隆抗体能够检测这种蛋白质，它在细胞与细胞外基质之间的粘附中起着重要作用，特别是与纤维蛋白、胶原和维蛋白等配体结合。这种相互作用对于许多细胞过程至关重要，包括细胞迁移、增殖和存活，因为Integrin α5有助于将信号从细胞外环境传递到细胞内部。Integrin α5 (P1D6) 抗体有助于研究人员研究这种蛋白质如何调节细胞骨架组织，这对于维持细胞形状和实现运动至关重要。Anti-Integrin α5 抗体 (P1D6) 支持对正常生理过程和病理状况（如癌症转移和组织修复）的研究，通过研究这种蛋白质与各种配体和信号分子的相互作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α5/ITGA5/CD49e 抗体 (P1D6) 参考文献:

  1. 血管内皮生长因子受体-1 由内皮细胞沉积在细胞外基质中，是 alpha 5 beta 1 整合素的配体。  |  Orecchia, A., et al. 2003. J Cell Sci. 116: 3479-89. PMID: 12865438
  2. ADMIDAS 阳离子结合位点在整合素 alpha 5 beta 1 的配体识别中的作用。  |  Mould, AP., et al. 2003. J Biol Chem. 278: 51622-9. PMID: 14532288
  3. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  4. Cbl 介导的 alpha5 整合素亚基泛素化介导了 FGFR2 激活诱导的纤维粘连依赖性成骨细胞脱离和凋亡。  |  Kaabeche, K., et al. 2005. J Cell Sci. 118: 1223-32. PMID: 15728256
  5. 整合素 alpha5/beta1 的表达介导了结肠癌细胞中 HER-2 的下调。  |  Kuwada, SK., et al. 2005. J Biol Chem. 280: 19027-35. PMID: 15757908
  6. 流式细胞仪检测发现，整合素α5与附件蛋白A2的耦合会驱动内皮细胞活化。  |  Zhang, C., et al. 2020. Circ Res. 127: 1074-1090. PMID: 32673515
  7. 巨噬细胞特异性整合素α5在心肌梗死中的保护作用与血管生成增强有关。  |  Li, R., et al. 2023. Nat Commun. 14: 7555. PMID: 37985764
  8. 通过影响细胞外基质沉积，靶向成纤维细胞中的整合素α5可增强结直肠癌对PD-L1阻断剂的反应。  |  Lu, L., et al. 2023. J Immunother Cancer. 11: PMID: 38040421
  9. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α5/ITGA5/CD49e 抗体 (P1D6)

sc-13547
200 µg/ml
RMB2377.00

Integrin α5/ITGA5/CD49e (P1D6): m-IgG3 BP-HRP 套装

sc-550545
200 µg Ab; 40 µg BP
RMB2662.00

Integrin α5/ITGA5/CD49e 抗体 (P1D6) FITC

sc-13547 FITC
200 µg/ml
RMB2482.00

Integrin α5/ITGA5/CD49e 抗体 (P1D6) PE

sc-13547 PE
200 µg/ml
RMB2580.00

Can Integrin α5 (P1D6): sc-13547 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Professor Griffin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin α5 (P1D6): sc-13547 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24

Integrin α5 抗体 (P1D6): sc-13547，can this antibody be used for block experiemnt, inhibition the function of Integrin a5?

Asked by: Lemon
Thank you for your question. This mouse monoclonal antibody, Integrin α5 (P1D6): sc-13547, is not recommended for blocking or inhibition studies of the Integrin α5 protein. We have not tested the antibody in this type of biological activity application. And we are not aware of any literature citing use of the antibody in this application. Integrin α5 (P1D6): sc-13547 is currently recommended for detection of Integrin α5 of human and primate origin by WB, IP, IF, IHC(P) and FCM.
Answered by: Technical Support
Date published: 2016-12-01
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Rated 5 out of 5 by from Positive resultsWe had been used a5 antibodies from another source before but noticed the results are not consistent, varying with batches of antibodies. This antibody works great on human kidney tissues. The IHC results look identical as another α5 antibody (MFR5/5H10): sc-23941.
Date published: 2017-06-06
Rated 5 out of 5 by from Excellent!This antibody works great in FCM analysis of human peripheral blood leukocytes.
Date published: 2017-01-19
Rated 5 out of 5 by from Nice membrane and cytoplasmic staining inNice membrane and cytoplasmic staining in human tissue without any background. -SCBT QC
Date published: 2015-01-23
Rated 5 out of 5 by from Produced good quality flow cytometry dataProduced good quality flow cytometry data -SCBT QC
Date published: 2015-01-08
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Integrin α5/ITGA5/CD49e 抗体 (P1D6) is rated 5.0 out of 5 by 4.
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