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Integrin α5/ITGA5/CD49e 抗体 (JBS5): sc-59762

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说明书
  • Integrin α5/ITGA5/CD49e抗体(JBS5)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 针对Jurkat细胞
  • 推荐用于 human 和 canine 来源的Integrin α5 IP, IF 和 FCM检测
  • 看 Integrin α5/ITGA5/CD49e (C-9): sc-376199,可查看有标记的 Integrin α5/ITGA5/CD49e 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Integrin α5/ITGA5/CD49e Antibody (JBS5). 的首选辅助检测试剂,这些试剂现与Integrin α5/ITGA5/CD49e Antibody (JBS5) 打包提供(请参阅下面的订购信息)。
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関連項目

Integrin α5抗体(JBS5)是一种小鼠单克隆IgG1抗体,可通过免疫沉淀(IP)、免疫荧光(IF)和流式细胞术(FCM)识别人类和犬类样本中的Integrin α5。Integrin α5在细胞粘附中起着至关重要的作用,主要位于细胞表面,抗Integrin α5抗体(JBS5)可检测与β1亚基形成的异二聚体,从而形成α5β1整合素受体。该受体对于与纤维连接蛋白等细胞外基质成分的结合至关重要,而纤维连接蛋白对于组织修复和发育等各种细胞过程至关重要。细胞表面的整合素α5有助于细胞附着到细胞外基质上,促进细胞迁移和增殖,这对于伤口愈合和胚胎发育至关重要。此外,整合素α5与纤维粘连蛋白的相互作用不仅稳定了细胞粘附,还启动了影响细胞行为的细胞内信号通路,使整合素α5成为维持组织完整性和调节细胞对环境信号反应的关键因素。Integrin α5 (JBS5) 单克隆抗体是研究人员在人类和犬类模型中研究这些基本过程的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α5/ITGA5/CD49e 抗体 (JBS5) 参考文献:

  1. 整合素 alpha5/beta1 的表达介导了结肠癌细胞中 HER-2 的下调。  |  Kuwada, SK., et al. 2005. J Biol Chem. 280: 19027-35. PMID: 15757908
  2. 整合素α5和四跨膜TM4SF5之间的合作可调节血管内皮生长因子介导的血管生成活性。  |  Choi, S., et al. 2009. Blood. 113: 1845-55. PMID: 19036703
  3. 纤维粘连蛋白基质的分段组装需要rap1b和整合素α5。  |  Lackner, S., et al. 2013. Dev Dyn. 242: 122-31. PMID: 23192979
  4. 整合素α5通过N-糖基化抑制表皮生长因子受体的磷酸化及其细胞增殖信号的传递  |  Hang, Q., et al. 2015. J Biol Chem. 290: 29345-60. PMID: 26483551
  5. 整合素α5促进肿瘤进展,是食管鳞状细胞癌的一个独立的不利预后因素。  |  Xie, JJ., et al. 2016. Hum Pathol. 48: 69-75. PMID: 26772401
  6. 16 kDa vasoinhibin与内皮细胞上的整合素α5β1结合,诱导细胞凋亡。  |  Morohoshi, K., et al. 2018. Endocr Connect. 7: 630-636. PMID: 29622663
  7. 纤维连接蛋白和整合素α5在肌动蛋白细胞骨架重组和完成脂肪生成过程中的调控作用  |  Uetaki, M., et al. 2022. Mol Biol Cell. 33: ar78. PMID: 35704469
  8. γ-Bungarotoxin通过抑制整合素α5来损害血管内皮屏障功能。  |  Chen, W., et al. 2023. Toxicol Lett. 383: 177-191. PMID: 37392970
  9. 血小板因子4通过抑制整合素α5-FAK-ERK途径诱导骨质流失。  |  Li, W., et al. 2023. Animal Model Exp Med. 6: 573-584. PMID: 37565509
  10. 整合素-α5 表达及其在非小细胞肺癌进展中的作用。  |  Ka, M., et al. 2024. Cancer Sci.. PMID: 39581761

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α5/ITGA5/CD49e 抗体 (JBS5)

sc-59762
200 µg/ml
CNY2422.00

Integrin α5/ITGA5/CD49e (JBS5): m-IgG Fc BP-HRP 套装

sc-539139
200 µg Ab; 10 µg BP
CNY2715.00

Integrin α5/ITGA5/CD49e (JBS5): m-IgG1 BP-HRP 套装

sc-541287
200 µg Ab; 20 µg BP
CNY2715.00

I was wondering if the clone JBS5 means Integrin b5-a1, not b5 alone? Some website says JBS5 is for b5-a1. Thank you.

Asked by: Vicky1
Thank you for your question. Our antibody sc-59762 Integrin α5 (JBS5) will detect Integrin α5. I do not have any information regarding b5.
Answered by: Tech Service
Date published: 2019-06-20

If I want to use Integrin α5 (JBS5): sc-59762 monoclonal antibody for Flow Cytometry, what starting dilution do you recommend I use?

Asked by: Professor Griffin
We recommend a starting dilution of 1µg of antibody per million cells. Here is a link to our recommended protocol: https://www.scbt.com/scbt/resources/protocols/flow-cytometry
Answered by: Technical Support
Date published: 2017-02-24
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Rated 3 out of 5 by JL from Indirect FCM analysis of human peripheralIndirect FCM analysis of human peripheral blood leukocytes stained with Integrin 5 (JBS5), followed by PE-conjugated goat anti-mouse IgG: sc-3738. -SCBT QC
Date published: 2015-04-08
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Integrin α5/ITGA5/CD49e 抗体 (JBS5) is rated 3.0 out of 5 by 1.
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