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Integrin α4/ITGA4/CD49d Antibody (PS/2) - Flow Cytometry - Image 147394 — 整合素 a4 (PS/2): sc-52593. 用 Integrin a4 (PS/2) 染色 TK-1 细胞, 然后用 PerCP-Cy5. 5 结合的山羊抗大鼠 IgG 进行间接 FCM 分析: sc-45100. 黑线直方图代表同型对照--正常大鼠 IgG2b: sc-3884.

整合素 a4 (PS/2): sc-52593. 用 Integrin a4 (PS/2) 染色 TK-1 细胞, 然后用 PerCP-Cy5. 5 结合的山羊抗大鼠 IgG 进行间接 FCM 分析: sc-45100. 黑线直方图代表同型对照--正常大鼠 IgG2b: sc-3884.

Integrin α4/ITGA4/CD49d 抗体 (PS/2): sc-52593

Name: Integrin α4/ITGA4/CD49d抗体 (PS/2)
Brand: SCBIO
SKU: sc-52593
Price: 2377.0 CNY
Availability: InStock

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说明书

Integrin α4/ITGA4/CD49d 抗体 PS/2 是大鼠单克隆 IgG_2b, 在2篇文献中引用，提供 200 µg/ml
推荐用于 mouse, rat 和 human 来源的Integrin α4 IP, IF 和 FCM检测
还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
目前，我们还没有完成Integrin α4/ITGA4/CD49d 抗体 (PS/2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

查看产品引用文献(2)

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関連項目

此外 Integrin 抗体包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin α4抗体（PS/2）是一种大鼠单克隆IgG2b轻链抗体，可通过免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）等应用检测小鼠、大鼠和人类样本中的Integrin α4。整合素α4通过介导细胞与细胞外基质之间以及细胞自身之间的相互作用，在细胞粘附和迁移中发挥着至关重要的作用。整合素α4主要位于细胞表面，在细胞表面，整合素α4与β1或β7亚基形成异二聚体，从而与纤维粘连蛋白和血管细胞粘附分子-1（VCAM-1）等配体结合。整合素α4在细胞膜上的定位对白细胞的迁移和炎症部位的归巢功能至关重要，这对免疫反应和组织修复至关重要。此外，整合素α4 与配体的接合会触发细胞内信号通路，从而影响细胞的行为，包括存活、增殖和分化。抗整合素 α4 抗体（PS/2）可帮助研究人员深入了解细胞粘附和迁移的机制，这些机制是正常生理和各种病理情况（包括癌症转移和自身免疫性疾病）的基本过程。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor^® 是Molecular Probes Inc., OR., USA的商标

LI-COR^®和 Odyssey^® 是LI-COR Biosciences的注册商标

Integrin α4/ITGA4/CD49d 抗体 (PS/2) 参考文献:

整合素α4-14-3-3ζ-帕利林三元络合物可调节局部Cdc42活性并加速细胞迁移。 | Deakin, NO., et al. 2009. J Cell Sci. 122: 1654-64. PMID: 19401330
整合素α4的异常DNA甲基化：胆管癌转移的潜在新作用。 | Uhm, KO., et al. 2010. J Cancer Res Clin Oncol. 136: 187-94. PMID: 19655168
整合素α4阻断使耐药性前B急性淋巴细胞白血病对化疗敏感。 | Hsieh, YT., et al. 2013. Blood. 121: 1814-8. PMID: 23319569
人类乳腺癌中整合素α4的异常DNA甲基化。 | Do, SI., et al. 2014. Tumour Biol. 35: 7079-84. PMID: 24756760
整合素α4小分子抑制剂TBC3486对前B-ALL细胞的影响。 | Hsieh, YT., et al. 2014. Leukemia. 28: 2101-4. PMID: 24903479
人类前列腺癌中整合素α4和E-Cadherin基因的甲基化。 | Mostafavi-Pour, Z., et al. 2015. Pathol Oncol Res. 21: 921-7. PMID: 25743258
整合素α4参与调节胶质瘤诱导的骨髓间充质干细胞的迁移。 | Ma, JC., et al. 2015. Oncol Rep. 34: 779-86. PMID: 26034878
富马酸二甲酯可抑制多发性硬化模型中整合素α4的表达。 | Kihara, Y., et al. 2015. Ann Clin Transl Neurol. 2: 978-83. PMID: 26478898
血清腔含有两种先天样整合素α4highCD4+ T细胞，整合素α4β1+α6β1+α4β7-和α4β1+α6β1-α4β7+细胞。 | Yang, JI., et al. 2017. Immune Netw. 17: 392-401. PMID: 29302252
整合素α4介导ATDC5细胞与带负电荷的合成聚合物水凝胶的粘附，导致软骨分化。 | Hashimoto, D., et al. 2020. Biochem Biophys Res Commun. 528: 120-126. PMID: 32456794

订购信息

产品名称	产品编号	规格	价格	数量	收藏夹
Integrin α4/ITGA4/CD49d 抗体 (PS/2)	sc-52593	200 µg/ml	RMB2377.00
Integrin α4/ITGA4/CD49d 抗体 (PS/2) FITC	sc-52593 FITC	200 µg/ml	RMB2482.00
Integrin α4/ITGA4/CD49d 抗体 (PS/2) PE	sc-52593 PE	200 µg/ml	RMB2580.00

As a blocking antibodty, PS/2 can block the interaction between α4 and Vcam-1, so can it block the interaction between α4 and fibronectin？

Asked by: lalala

Thank you for your question. Integrin α4/ITGA4/CD49d antibody (PS/2) is not a blocking antibody.

Answered by: Technical Service SH

Date published: 2024-01-11

Can Integrin α4 (PS/2): sc-52593 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine

Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin α4 (PS/2): sc-52593 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.

Answered by: Technical Support

Date published: 2017-02-24

Rated 5 out of 5 by DefinitelyNotMatt from Reliable Antibody, Great for FlowThis antibody is well-cited and well-studied for use in flow cytometry. Very specific binding to Integrin alpha 4.

Date published: 2017-02-09

Rated 3 out of 5 by MS from Positive indirect FCM analysis of BALB/cPositive indirect FCM analysis of BALB/c splenocytes stained with Integrin 4 (PS/2), followed by PE-conjugated goat anti-rat IgG: sc-3740. -SCBT QC

Date published: 2014-04-08

Integrin α4/ITGA4/CD49d 抗体 (PS/2) is rated 4.0 out of 5 by 2.

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种属	基因名称	基因ID	染色体位置	亚型（mRNA）登录号	蛋白质登录号	OMIM™ 号码
Human	ITGA4	Entrez Gene ID: 3676	2q31.3	NM_000885, NM_001316312	UniProt ID: P13612	192975
Mouse	Itga4	Entrez Gene ID: 16401	2 C3	NM_010576	UniProt ID: Q00651	N/A

Integrin α4/ITGA4/CD49d 抗体 (PS/2): sc-52593

Integrin α4/ITGA4/CD49d 抗体 (PS/2) 参考文献:

優選的 Integrin α4/ITGA4/CD49d 抗體是 Integrin α4/ITGA4/CD49d 抗體 (A-7): sc-365209.

Integrin α4/ITGA4/CD49d 抗体 (PS/2)

Integrin α4/ITGA4/CD49d 抗体 (PS/2) FITC

Integrin α4/ITGA4/CD49d 抗体 (PS/2) PE

As a blocking antibodty, PS/2 can block the interaction between &alpha;4 and Vcam-1, so can it block the interaction between &alpha;4 and fibronectin？

Can Integrin &alpha;4 (PS/2): sc-52593 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

As a blocking antibodty, PS/2 can block the interaction between α4 and Vcam-1, so can it block the interaction between α4 and fibronectin？

Can Integrin α4 (PS/2): sc-52593 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?