Date published: 2025-9-7
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Histamine H1 Receptor Antibody (G-11) - Immunofluorescence - Image 151311
组胺 H1 受体抗体 (G-11): sc-374621. 对甲醇固定的 HeLa 细胞进行免疫荧光染色, 显示细胞质定位.
Histamine H1 Receptor Antibody (G-11) - Immunofluorescence - Image 151311
组胺 H1 受体抗体 (G-11): sc-374621. 对甲醇固定的 HeLa 细胞进行免疫荧光染色, 显示细胞质定位.
Histamine H1 Receptor Antibody (G-11) - Western Blotting - Image 153893
组胺 H1 受体抗体 (G-11): sc-374621. 组胺 H1 受体在未转染 (A) 和人组胺 H1 受体转染 (B) 的 HEK293T 全细胞裂解液中的表达的 Western 印迹分析.
组胺 H1 受体抗体 (G-11): sc-374621. 对甲醇固定的 HeLa 细胞进行免疫荧光染色, 显示细胞质定位.

Histamine H1 Receptor 抗体 (G-11): sc-374621

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说明书
  • Histamine H1 Receptor 抗体 G-11 是小鼠单克隆 IgG1 κ，Histamine H1 Receptor抗体, 在6篇文献中引用，规格为200 µg/ml
  • 特定于human起源的Histamine H1 Receptor细胞质域内氨基酸303-341之间的表位图谱
  • Histamine H1 Receptor 抗体 (G-11) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 Histamine H1 Receptor
  • 抗Histamine H1 Receptor抗体（G-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Histamine H1 Receptor (G-11): sc-374621的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是Histamine H1 Receptor Antibody (G-11) for WB applications. 的首选辅助检测试剂，这些试剂现与Histamine H1 Receptor Antibody (G-11) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外Histamine Receptor抗体，包括Histamine H3 Receptor

组胺H1受体抗体（G-11）是一种IgG1κ小鼠单克隆组胺H1受体抗体（也称作组胺受体H1抗体、组胺H1受体抗体、HH1R抗体、H1R抗体、组胺受体亚类H1抗体、HisH1抗体或H1-R抗体），能够通过WB、IP、IF和ELISA检测人类来源的组胺H1受体蛋白。组胺H1受体抗体（G-11）可以以非偶联型抗组胺H1受体抗体形式以及多种偶联型抗组胺H1受体抗体形式供应，包括琼脂糖、HRP、PE、FITC以及多种Alexa Fluor®偶联物。组胺是一种普遍表达的炎性介质，具有广泛的药理作用。具体来说，它在中枢神经系统、胃肠道、呼吸系统和免疫系统中发挥作用。组胺的作用由一组G蛋白偶联受体介导，即组胺H1、H2、H3和H4受体。编码人类组胺H1受体的基因定位于3号染色体p25区，在胎盘中表达量最高，在肺、骨骼肌、肾脏和大脑中表达量较低。小鼠组胺H2受体基因定位于13号染色体，在胃中高表达，在脑和心脏中表达量中等。编码人类组胺H3受体的基因位于20号染色体上，在丘脑中以六种替代剪接变体形式表达。人类组胺H4受体基因定位于18号染色体q11区，在骨髓和脾脏中表达量最为丰富，此外还表达于外周血白细胞、胸腺、小肠和结肠中。组胺受体对多种激动剂和拮抗剂有反应，因此成为哮喘、癫痫和心肌缺血等多种疾病潜在的治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Histamine H1 Receptor 抗体 (G-11) 参考文献:

  1. 发现组胺受体家族的新成员。  |  Nguyen, T., et al. 2001. Mol Pharmacol. 59: 427-33. PMID: 11179435
  2. 人类组胺 H3 受体剪接变体的基因组组织和特征。  |  Cogé, F., et al. 2001. Biochem J. 355: 279-88. PMID: 11284713
  3. 人类组胺 H4 受体基因的结构和表达。  |  Cogé, F., et al. 2001. Biochem Biophys Res Commun. 284: 301-9. PMID: 11394877
  4. [组胺 H4 受体的鉴定和特征描述]。  |  Oda, T. and Matsumoto, S. 2001. Nihon Yakurigaku Zasshi. 118: 36-42. PMID: 11496825
  5. 组胺受体：概述。  |  Parsons, ME. 1991. Scand J Gastroenterol Suppl. 180: 46-52. PMID: 1675026
  6. 组胺H1受体拮抗剂治疗的药代动力学优化。  |  Simons, FE. and Simons, KJ. 1991. Clin Pharmacokinet. 21: 372-93. PMID: 1685361
  7. 非镇静组胺H1受体拮抗剂。  |  Mann, KV., et al. 1989. Clin Pharm. 8: 331-44. PMID: 2568212
  8. 在肠粘膜细胞模型中，组胺通过组胺 H1 受体增强毒蕈碱受体诱导的钙对乙酰胆碱的反应。  |  Pfanzagl, B., et al. 2022. Clin Exp Pharmacol Physiol. 49: 1059-1071. PMID: 35652717
  9. 组胺H1受体拮抗剂可减轻严重烧伤后儿茶酚胺激增和器官损伤。  |  Wang, J., et al. 2023. Front Endocrinol (Lausanne). 14: 1068925. PMID: 36843581
  10. 人类组胺 H1 受体基因的分子克隆。  |  Fukui, H., et al. 1994. Biochem Biophys Res Commun. 201: 894-901. PMID: 8003029
  11. 组胺可通过 H2 和 H3 受体抑制肥大细胞释放肿瘤坏死因子α。  |  Bissonnette, EY. 1996. Am J Respir Cell Mol Biol. 14: 620-6. PMID: 8652190
  12. 小鼠组胺 H2 受体基因的克隆, RNA 表达和染色体位置。  |  Kobayashi, T., et al. 1996. Genomics. 37: 390-4. PMID: 8938453

订购信息

产品名称产品编号规格价格数量收藏夹

Histamine H1 Receptor 抗体 (G-11)

sc-374621
200 µg/ml
RMB2377.00

Histamine H1 Receptor (G-11): m-IgG Fc BP-HRP 套装

sc-527492
200 µg Ab; 10 µg BP
RMB2662.00

Histamine H1 Receptor (G-11): m-IgG1 BP-HRP 套装

sc-532865
200 µg Ab; 20 µg BP
RMB2662.00

Histamine H1 Receptor 抗体 (G-11) AC

sc-374621 AC
500 µg/ml, 25% agarose
RMB3129.00

Histamine H1 Receptor 抗体 (G-11) HRP

sc-374621 HRP
200 µg/ml
RMB2377.00

Histamine H1 Receptor 抗体 (G-11) FITC

sc-374621 FITC
200 µg/ml
RMB2482.00

Histamine H1 Receptor 抗体 (G-11) PE

sc-374621 PE
200 µg/ml
RMB2580.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 488

sc-374621 AF488
200 µg/ml
RMB2685.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 546

sc-374621 AF546
200 µg/ml
RMB2685.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 594

sc-374621 AF594
200 µg/ml
RMB2685.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 647

sc-374621 AF647
200 µg/ml
RMB2685.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 680

sc-374621 AF680
200 µg/ml
RMB2685.00

Histamine H1 Receptor 抗体 (G-11) Alexa Fluor® 790

sc-374621 AF790
200 µg/ml
RMB2685.00

Histamine H1 Receptor (G-11) 中和勝肽

sc-374621 P
100 µg/0.5 ml
RMB511.00

Will this work for tissue sample from rat?

Asked by: lymphtic lab
Thank you for your question. We have not yet tested this antibody in rat samples and so it is not a recommended species at this time. Check back for updates!
Answered by: Technical Support
Date published: 2019-06-16

What application is the blocking peptide sc-374621 P appropriate for?

Asked by: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2024-12-19
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Rated 5 out of 5 by from Works in WBI got a sample of this antibody previously and tested it in WB (1:100). A clear band at the predicted position was observed. Good product!
Date published: 2018-04-23
Rated 5 out of 5 by from Works for Western blotUse the Ab to determine the expression of H1R in endothelial cells by Western blotting. It works very well; single band.
Date published: 2017-10-19
Rated 5 out of 5 by from Histamine receptor 1 (G-11) antibodywork well in IHC at 1:50, mouse brain slice. but we recommend to use sample before final experiment.
Date published: 2017-06-28
Rated 5 out of 5 by from Produced beautiful immunofluorescence cytoplasmicProduced beautiful immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-01-31
Rated 5 out of 5 by from Nice Western Blot data of Histamine H1 ReceptorNice Western Blot data of Histamine H1 Receptor expression in non-transfected and human Histamine H1 Receptor transfected whole cell lysates. -SCBT QC
Date published: 2013-06-02
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Histamine H1 Receptor 抗体 (G-11) is rated 5.0 out of 5 by 5.
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