Date published: 2025-9-8
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GSDMDC1 Antibody (64-Y) - Western Blotting - Image 33516
GSDMDC1 抗体 (64-Y): sc-81868. Western 印迹分析 Jurkat 全细胞裂解液中 GSDMDC1 的表达.
GSDMDC1 抗体 (64-Y): sc-81868. Western 印迹分析 Jurkat 全细胞裂解液中 GSDMDC1 的表达.

GSDMDC1 抗体 (64-Y): sc-81868

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说明书
  • GSDMDC1 抗体 64-Y 是小鼠单克隆 IgG1 κ，GSDMDC1抗体, 在53篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组GSDMDC1
  • 推荐用于 human 来源的GSDMDC1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取GSDMDC1 (64-Y): sc-81868的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 GSDMDC1 抗体 (64-Y) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与GSDMDC1 抗体 (64-Y) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

gasdermin 抗体

GSDMDC1抗体(64-Y)是一种IgG1 κ小鼠单克隆GSDMDC1抗体，通过WB、IP、IF、IHC(P)和ELISA检测人源性GSDMDC1蛋白。GSDMDC1抗体(64-Y)可提供非偶联的抗GSDMDC1抗体。编码484个氨基酸蛋白的基因GSDMDC1定位于人类8号染色体，该染色体由近1.46亿个碱基组成，编码约800个基因。8号染色体部分易位伴c-Myc基因扩增见于一些白血病和淋巴瘤，通常与不良预后相关。8号染色体的部分与精神分裂症和双相情感障碍有关。8号染色体三体，也被称为Warkany综合征2，最常导致早期流产，但偶尔在存活的患者中以镶嵌形式出现，这些患者有不同程度的症状，包括智力和运动发育迟缓，以及某些面部和发育缺陷。WRN是由8号染色体编码的DNA解旋酶，在早期衰老障碍维尔纳综合征患者中表现出缺陷。8号染色体还与Pfeiffer综合征、先天性甲状腺功能减退症和Waardenburg综合征相关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GSDMDC1 抗体 (64-Y) 参考文献:

  1. 第 8 和第 10 染色体研讨会。  |  Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
  2. 在引入了正常 8 号染色体的维尔纳综合征细胞系中优先表达完整的 WRN 基因。  |  Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
  3. II 型瓦登堡综合征新基因座的细胞遗传学图谱。  |  Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
  4. 通过对 11 项躁狂症关联研究的综合分析，有力地证明了 6q 和 8q 染色体上的易感基因位点。  |  McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
  5. 人类第 8 号染色体的 DNA 序列和分析。  |  Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
  6. 人类癌症中早衰 Werner 综合征基因的表观遗传失活。  |  Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
  7. 具有 Burkitt 样细胞的非霍奇金淋巴瘤与 c-Myc 扩增和预后不良缔合作用。  |  Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002

订购信息

产品名称产品编号规格价格数量收藏夹

GSDMDC1 抗体 (64-Y)

sc-81868
100 µg/ml
RMB2377.00

GSDMDC1 (64-Y): m-IgG Fc BP-HRP 套装

sc-537263
100 µg Ab; 10 µg BP
RMB2662.00

GSDMDC1 (64-Y): m-IgGκ BP-HRP 套装

sc-534492
100 µg Ab; 40 µg BP
RMB2662.00

GSDMDC1 (64-Y): m-IgG1 BP-HRP 套装

sc-545115
100 µg Ab; 20 µg BP
RMB2662.00

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email [email protected].
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email [email protected].
Answered by: BlakeJ
Date published: 2025-07-17

Hello, I am curious about the specificity of this antibody. In my research it is important that the antibody is specific to the active form of GSDMD (aka GSDMD-N or GSDMD N terminal) and I'm wondering if this product is suitable for my work.

Asked by: Libby
Thank you for your question. For assistance please contact Technical Service. Please call 800-457-3801 or email [email protected].
Answered by: BlakeJ
Date published: 2025-07-17

Blocking should be done either in 5%BSA or 5%non-fat milk.please suggest

Asked by: ras21
Thank you for your question. This antibody has been established with UltraCruz® Blocking Reagent: sc-516214. The optimal blocking reagent is also dependent on the type of sample that is being analyzed. If you encounter unspecific signals, you should use a buffer based on milk-powder or switch to a BSA buffer if your signals are too weak and being overblocked.
Answered by: Tech Support Europe
Date published: 2021-02-09

Does this antibody recognize the cleaved band?

Asked by: ZAQ1
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2021-01-27

if the antibody will detect the gasdeminD N-terminal fragment?

Asked by: Tang tang
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2023-07-04

I have the same question as Tang Tang : Does the GSDMDC1 Antibody (64-Y): sc-81868 detect the human gasdemin D N-terminal fragment ?? Thank you.

Asked by: MariL
Thank you for your question. This mouse monoclonal antibody was raised against full length recombinant protein of human origin, and the exact epitope recognized has not been determined. We have not conducted any experiments to confirm whether or not the antibody can detect specifically any cleaved or N-terminal fragment of the protein. We would recommend you consult the product citations to see how others are publishing using this antibody.
Answered by: Technical Support
Date published: 2019-01-14

I would like to ask abput free sample of GSDMD antibody.

Asked by: MartaZ
Thank you for your question. If you have an interest in testing a free 10 µg sample of GSDMDC1 (64-Y): sc-81868 please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-26
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Rated 5 out of 5 by from its effect is goodwhen i was master, i used it to do some experiments,and my work get the nod of my teacher. and I graduated and published a good article
Date published: 2023-03-13
Rated 4 out of 5 by from WORKS!!Thx for the sample, it's works in THP-1 lysate and SN, but i really want its can get the P30 signal in WB..
Date published: 2017-12-27
Rated 3 out of 5 by from It is a good antibodyThanks for the free 10 µg sample from the company, but in my study and my vascular endothelial cell, the dilution 1:500 was used, the graph is not good, I need more study.
Date published: 2017-09-21
Rated 3 out of 5 by from Works... but low specificity for a mAbI'm sure that this antibody is good for validating transfections or something along those lines (though one could just tag a transfected protein)... for cells (e.g. THP1 monocytes) that don't seem to express as much GSDMD, this antibody has pretty high background in my hands. Though the strongest band is 52 kDa, there are lots of other bands of lesser but still quite visible intensity (these do not correspond to caspase-cleaved GSDMD, either). Picture attached to show what I mean.
Date published: 2017-07-14
Rated 5 out of 5 by from good for WB and IFI used this antibody for immunofluorescence (1:300) and WB(1:800), and I got very good and clean results for both application.
Date published: 2017-05-24
Rated 4 out of 5 by from Great Ab!Works well for western blotting on THP1 cell lysates.
Date published: 2017-03-29
Rated 5 out of 5 by from great GSDMDC1 detectionWorks well with paraffin-embedded sections for IHC. Great for human GSDMDC1 detection.
Date published: 2017-01-12
Rated 5 out of 5 by from tumor samplesWorked well for western blot with tumor samples,Good signal in western blot using 1:1000.
Date published: 2016-12-17
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GSDMDC1抗体 (64-Y) is rated 4.2 out of 5 by 12.
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