Date published: 2025-9-6
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GRK 6 Antibody (XX-4) - Western Blotting - Image 134891
GRK 6 抗体 (XX-4): sc-100380. BJAB (A) 和 Ramos (B) 全细胞裂解液中 GRK 6 表达的 Western 印迹分析.
GRK 6 抗体 (XX-4): sc-100380. BJAB (A) 和 Ramos (B) 全细胞裂解液中 GRK 6 表达的 Western 印迹分析.

GRK 6 抗体 (XX-4): sc-100380

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说明书
  • GRK 6抗体(XX-4)是小鼠单克隆IgG2a κ, 在4篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组GRK 6
  • 推荐用于 mouse, rat 和 human 来源的GRK 6 WB, IP 和 ELISA检测
  • 目前，我们还没有完成GRK 6 抗体 (XX-4)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 GRK 抗体 包括 GRK 1, GRK 2, GRK 3, GRK 4, GRK 6和GRK 7

由异源三聚体G蛋白介导的信号转导是一个动态调节的过程，尽管激动剂持续存在，但信号的强度会随时间而降低。这种现象被称为激动剂介导的脱敏，涉及两类酶对受体的磷酸化。第一类由第二信使调节的激酶组成，如c-AMP依赖的蛋白激酶A和蛋白激酶C。第二类包括G蛋白偶联受体激酶(GRKs)。目前已经发现了GRK家族的至少七个成员。这些包括视紫红质激酶(GRK 1)、两种形式的β-肾上腺素能受体激酶: GRK 2 (βARK, βARK1)和GRK 3 (βARK2)、IT-11 (GRK 4)、GRK 5、GRK 6和GRK 7。GRKs对受体的磷酸化似乎严格依赖于处于激动剂激活状态的受体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GRK 6 抗体 (XX-4) 参考文献:

  1. GRK6 可使 IκBα 在 Ser(32)/Ser(36) 处磷酸化，并增强 TNF-α 诱导的炎症。  |  Ohba, Y., et al. 2015. Biochem Biophys Res Commun. 461: 307-13. PMID: 25881508
  2. GRK6启动子甲基化异常与下咽鳞状细胞癌的不良预后有关。  |  Qiu, X., et al. 2016. Oncol Rep. 35: 1027-33. PMID: 26718636
  3. 肺腺癌中 GRK6 表达下降的预后价值  |  Yao, S., et al. 2016. J Cancer Res Clin Oncol. 142: 2541-2549. PMID: 27601164
  4. GRK6调节ROS反应并维持造血干细胞的自我更新。  |  Le, Q., et al. 2016. Cell Death Dis. 7: e2478. PMID: 27882944
  5. GRK6的过表达与结直肠癌的进展和预后有关。  |  Tao, R., et al. 2018. Oncol Lett. 15: 5879-5886. PMID: 29552218
  6. GRK6 通过其对血小板中 GPCR 信号传导的限速作用来调节对损伤的止血反应。  |  Chen, X., et al. 2020. Blood Adv. 4: 76-86. PMID: 31899801
  7. 消耗 GRK6 可诱导肺腺癌中的 HIF 活性  |  Yao, S., et al. 2021. Front Oncol. 11: 654812. PMID: 34136390
  8. G 蛋白偶联受体激酶 6 (GRK6) 通过影响原胰岛素向胰岛素的转化来调节胰岛素的加工和分泌。  |  Varney, MJ., et al. 2022. J Biol Chem. 298: 102421. PMID: 36030052
  9. GRK6棕榈酰化增加其膜易位，通过PI3K/ AKT途径促进LPS诱导的kuppfer细胞炎症。  |  Tao, L., et al. 2023. Int Immunopharmacol. 117: 109933. PMID: 37012861
  10. GRK6过表达对肺动脉高压的治疗潜力和保护作用  |  Liu, C., et al. 2023. Vascul Pharmacol. 153: 107233. PMID: 37742818

订购信息

产品名称产品编号规格价格数量收藏夹

GRK 6 抗体 (XX-4)

sc-100380
100 µg/ml
$333.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with GRK 6 (XX-4): sc-100380 antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 4 out of 5 by from Signal via western blot analysis of GRK 6Signal via western blot analysis of GRK 6 expression in non-transfected 293T: sc-117752, human GRK 6 transfected 293T: sc-158578 and BJAB whole cell lysates. -SCBT QC
Date published: 2015-04-18
Rated 4 out of 5 by from Positive western blot analysis of GRK 6 expressionPositive western blot analysis of GRK 6 expression in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-04-17
Rated 4 out of 5 by from Western blot publication using rat striatumWestern blot publication using rat striatum samples -SCBT Publication Review
Date published: 2015-03-16
Rated 4 out of 5 by from Signal via western blot analysis of GRK 6Signal via western blot analysis of GRK 6 expression in BJAB (A) and Ramos (B) whole cell lysates. -SCBT QC
Date published: 2015-01-30
Rated 4 out of 5 by from Western blot publication using rat renalWestern blot publication using rat renal cortex samples -SCBT Publication Review
Date published: 2013-02-04
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GRK 6 抗体 (XX-4) is rated 4.0 out of 5 by 5.
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