Date published: 2025-9-7
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Fos B Antibody (F-7) - Immunohistochemistry - Image 348024
Fos B 抗体 (F-7): sc-398595. 福尔马林固定, 石蜡包埋的人类胎盘组织的免疫过氧化物酶染色显示滋养细胞的核染色.
Fos B 抗体 (F-7): sc-398595. 福尔马林固定, 石蜡包埋的人类胎盘组织的免疫过氧化物酶染色显示滋养细胞的核染色.

Fos B 抗体 (F-7): sc-398595

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说明书
  • Fos B 抗体 F-7 是小鼠单克隆 IgG1 κ，Fos B抗体, 在10篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Fos B的氨基酸75-150
  • Fos B 抗体 (F-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Fos B
  • 抗Fos B抗体（F-7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-398595 X, 200 µg/0.1 ml)
  • 关于如何获取Fos B (F-7): sc-398595的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成Fos B 抗体 (F-7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

c-Fos 抗体

Fos B抗体（F-7）是一种IgG1 κ小鼠单克隆Fos B抗体，可通过WB、IP、IF、IHC（P）和ELISA检测小鼠、大鼠和人类的Fos B蛋白。Fos B抗体（F-7）既可作为非偶联抗Fos B抗体形式提供，也可作为多种偶联形式的抗Fos B抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。v-Fos癌基因最初被鉴定为两种独立的小鼠骨肉瘤病毒分离株和一种禽类肾母细胞瘤病毒的转化基因。其细胞同源物c-Fos编码一种核磷蛋白，该蛋白可被多种因子迅速且瞬时诱导，并作为几个基因的转录调节因子。与形成同源二聚体和异源二聚体并与特定的DNA TPA反应元件（TREs）结合的c-Jun蛋白不同，c-Fos蛋白仅在与Jun基因家族成员结合形成异源二聚体时才具有活性。小鼠Fos B编码一个由338个氨基酸组成的核蛋白，与c-Fos具有70%的同源性，表现出与c-Fos相似的表达动力学，并与c-Jun和Jun B形成异源二聚体，这些二聚体与TRE DNA反应元件结合。c-Fos和Fos B的功能同源物包括Fra-1和Fra-2基因。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Fos B 抗体 (F-7) 参考文献:

  1. 在小鼠海马体内用卡因酸治疗后，Nrf2/Fos-B复合物的可能形成增强了核抗氧化剂反应元件的结合活性。  |  Ogita, K., et al. 2004. Neuropharmacology. 46: 580-9. PMID: 14975682
  2. 缺乏即刻早期基因 fos B 的小鼠对缺氧的通气适应能力受损。  |  Malik, MT., et al. 2005. Respir Physiol Neurobiol. 145: 23-31. PMID: 15652785
  3. 大鼠脊髓神经元中JUN B、JUN D和FOS B蛋白质的顺序表达：痛觉感受过程中的转录级联操作。  |  Herdegen, T., et al. 1991. Neurosci Lett. 129: 221-4. PMID: 1745403
  4. 过表达 c-jun, junB 或 junD 对细胞生长的影响各不相同。  |  Castellazzi, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 8890-4. PMID: 1924349
  5. fos基因家族的另一成员fra-2的分离和特征描述。  |  Nishina, H., et al. 1990. Proc Natl Acad Sci U S A. 87: 3619-23. PMID: 2110368
  6. 一种新型生长因子激活基因的产物 fos B 能与 JUN 蛋白相互作用，增强其 DNA 结合活性。  |  Zerial, M., et al. 1989. EMBO J. 8: 805-13. PMID: 2498083
  7. 一种从肾母细胞瘤中分离出来的禽转化逆转录病毒，携带 fos 基因作为癌基因。  |  Nishizawa, M., et al. 1987. J Virol. 61: 3733-40. PMID: 2824811
  8. c-fos 原癌基因产物的染色质关联和 DNA 结合特性。  |  Renz, M., et al. 1987. Nucleic Acids Res. 15: 277-92. PMID: 3103098
  9. Fos 蛋白复合物与离体细胞核中的 DNA 相关联，并与 DNA 纤维素结合。  |  Sambucetti, LC. and Curran, T. 1986. Science. 234: 1417-9. PMID: 3491427
  10. 病毒诱发小鼠骨肉瘤。  |  Finkel, MP., et al. 1966. Science. 151: 698-701. PMID: 5218049
  11. FBR 小鼠骨肉瘤病毒。I. 75,000-Da gag-fos 融合产物的分子分析和特征。  |  Curran, T. and Verma, IM. 1984. Virology. 135: 218-28. PMID: 6203214
  12. 初级传入刺激后尾核神经元中Fos家族成员的变化：fos B和c-fos增强。  |  Walther, D., et al. 1993. Brain Res Mol Brain Res. 17: 155-9. PMID: 8381898

订购信息

产品名称产品编号规格价格数量收藏夹

Fos B 抗体 (F-7)

sc-398595
200 µg/ml
RMB2377.00

Fos B 抗体 (F-7) X

sc-398595 X
200 µg/0.1 ml
RMB2377.00

Fos B 抗体 (F-7) AC

sc-398595 AC
500 µg/ml, 25% agarose
RMB3129.00

Fos B 抗体 (F-7) HRP

sc-398595 HRP
200 µg/ml
RMB2377.00

Fos B 抗体 (F-7) FITC

sc-398595 FITC
200 µg/ml
RMB2482.00

Fos B 抗体 (F-7) PE

sc-398595 PE
200 µg/ml
RMB2580.00

Fos B 抗体 (F-7) Alexa Fluor® 488

sc-398595 AF488
200 µg/ml
RMB2685.00

Fos B 抗体 (F-7) Alexa Fluor® 546

sc-398595 AF546
200 µg/ml
RMB2685.00

Fos B 抗体 (F-7) Alexa Fluor® 594

sc-398595 AF594
200 µg/ml
RMB2685.00

Fos B 抗体 (F-7) Alexa Fluor® 647

sc-398595 AF647
200 µg/ml
RMB2685.00

Fos B 抗体 (F-7) Alexa Fluor® 680

sc-398595 AF680
200 µg/ml
RMB2685.00

Fos B 抗体 (F-7) Alexa Fluor® 790

sc-398595 AF790
200 µg/ml
RMB2685.00

We used this Fos B Antibody (F-7): sc-398595 in a concentration of 1:200 in IHC but the signal was weak. Any suggestion?

Asked by: PANAGIOTIS
Thank you for your question. A weak signal can have a wide variety of causes. Please contact our technical service so we can help you.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

Qué tal, quisiera saber si este anticuerpo sc-398595 es funcional en inmunohistoquímica por flotación y si está disponible en México, ojalá pudiera responder en calidad de urgente. Gracias

Asked by: DaniVelarde
Muchas gracias por su pregunta. El anticuerpo está recomendado para detectar Fos B mediante WB, IP, IF, IHC(P) y ELISA. En IHC(P ) ha sido testado sobre portaobjectos (e.g. sc-363562). Si necesita más información y conocer la disponibilidad en Mexico, contacte con nuestro costumer care: [email protected]
Answered by: Technical Support Europe
Date published: 2018-12-21

Can Fos B Antibody (F-7) sc-398595 be used to detect DeltaFosB protein in rat tissue?

Asked by: Marcelo
Thank you for your question. Unfortunately this antibody has not been epitope mapped, so I am not sure if it can or can not detect Delta FosB. Please contact our Technical Service Department by phone, e-mail or live chat.
Answered by: Tech Service
Date published: 2025-02-27

This is Jing Li coming from New Jersey medical School. I asked the supply center to place order for Fos B antibody (sc-398595). But the supply center said it is not available from your storeroom. Do you this antibody is ready to sell? Thanks. Jing Li

Asked by: Jing1234567
Thank you for your question! We do have this antibody, sc-398595, Fos B, in stock, so there should be no problems ordering it. Please contact our Customer Service group if you have any further issues ordering this product. You can reach us at: by phone, (800)-457-3801 option 1, email <[email protected]>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-04-03

Can Fos B (F-7): sc-398595 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Fos B (F-7): sc-398595 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from Not workingWe expected positive staining in hippocampal cells, which were completely absent at the concentrations of 1:200 and 1:100 in samples from two different experiments.
Date published: 2021-12-13
Rated 1 out of 5 by from Not workingWe expected a nuclear staining on colon cancer which is totally absent.
Date published: 2020-10-21
Rated 1 out of 5 by from IF and Western blot can not be useI used anti-FosB （F-7) to do IF and WB，and tested several dilution (1:50, 1:200, 1:500). But I had no any positive results. I had negative and positive control in my experiments. IF: only cytoplasms have off-target immunostaining. WB: only have 116 kDa bands
Date published: 2019-06-26
Rated 1 out of 5 by from No signal with immunofluorescenceTried a sample of this (among others) and tested a range from 1:50 to 1:500 and lots of background, but no specific staining for Fos B.
Date published: 2018-03-15
Rated 3 out of 5 by from I didn't get positive signal1month ago, I got the 10ul antibody sample. Then, I tested it by gradient like 1:200, 1:500 and 1:1000. But I didn't get positive signal on my brain slices.
Date published: 2017-08-25
Rated 4 out of 5 by from FosB antibody (F7): sc-398595I got the sample of this antibody a couple weeks ago. I am glad to test it in 4%PFA fixed brain sections using immunofluerence method. It work very well at the concentration 1:100 and 1:500. However, I did not get the positive data when I used it in immunohistochemistry by DAB staining. I'll will try a different secondary antibody to test whether it can work by DAB staining.
Date published: 2017-03-24
Rated 5 out of 5 by from funzionamento ottimalel'anticorpo funziona molto bene anche alle diluizioni più alte suggerite dal rivenditore
Date published: 2017-03-22
Rated 5 out of 5 by from FOS B Western blot of mouse lymphomasI received 10 micrometer of Fos B antibody and we purchased the secondary antibody recommended Santa cruz m-igGk BP-HRP.
Date published: 2017-02-08
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Fos B 抗体 (F-7) is rated 3.3 out of 5 by 11.
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