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EphB3 Antibody (7E5) - Western Blotting - Image 32814
EphB3 抗体 (7E5): sc-100299. 对 HeLa 全细胞裂解液中 EphB3 的表达进行 Western 印迹分析.
EphB3 抗体 (7E5): sc-100299. 对 HeLa 全细胞裂解液中 EphB3 的表达进行 Western 印迹分析.

EphB3 抗体 (7E5): sc-100299

4.6(5)
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说明书
  • EphB3抗体(7E5)是小鼠单克隆IgG1 κ, 在4篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组EphB3
  • 推荐用于 mouse, rat 和 human 来源的EphB3 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前，我们还没有完成EphB3 抗体 (7E5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 Eph 抗体 包括 EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphB1, EphB2和EphB3

Eph亚家族是迄今为止发现的最大的受体蛋白酪氨酸激酶家族。虽然这些受体的生物活性尚未确定，但越来越多的证据表明它们与中枢神经系统功能和发育有关。人类来源的Eph亚家族受体（及其鼠/鸟类同源物）包括EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) 和 EphB6 (Mep). Eph 受体的配体包括与EphA3和EphB1结合的 ephrin-A4 (LERK-4) 。此外，ephrin-A2 (ELF-1)是EphA4的配体，ephrin-A3 (Ehk1-L) 是EphA5的配体，ephrin-B2 (Htk-L) 是 EphB4 (Htk) 的配体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

EphB3 抗体 (7E5) 参考文献:

  1. EphB3标记发育中胰脏中脱落的内分泌祖细胞。  |  Villasenor, A., et al. 2012. Dev Dyn. 241: 1008-19. PMID: 22434763
  2. EphB3受体在调节头颈部肿瘤生长、细胞迁移和对PI3K抑制剂的反应中的作用。  |  Bhatia, S., et al. 2018. Mol Cancer Ther. 17: 2049-2059. PMID: 29970482
  3. 受体酪氨酸激酶EphB3：大肠癌的预后指标。  |  Xuan, Z., et al. 2020. Pathol Oncol Res. 26: 541-549. PMID: 30535864
  4. 肝外胆管癌中 EphB3 和 Dysadherin 表达的预后和临床病理意义  |  Wu, Z., et al. 2020. Cancer Manag Res. 12: 221-232. PMID: 32021438
  5. EPHB3在大肠癌中的表达谱和预后意义。  |  Jang, BG., et al. 2020. Biomolecules. 10: PMID: 32294981
  6. EphB3作为发育和修复性骨形成的潜在介质。  |  Kamath, RAD. and Benson, MD. 2023. Cells Tissues Organs. 212: 125-137. PMID: 34695818
  7. 敲除EphB3可部分通过AKT信号通路抑制细胞增殖，并抑制食管鳞状细胞癌的上皮-间质转化。  |  Tang, L., et al. 2022. Transl Cancer Res. 11: 85-98. PMID: 35261887
  8. EphB3通过Kalirin在癫痫发作和癫痫形成中的作用和机制。  |  Huang, H., et al. 2024. Mol Cell Neurosci. 128: 103915. PMID: 38143048
  9. EphB3受体抑制剂通过抑制EGFR-PI3K/AKT信号通路抑制胶质瘤的侵袭、迁移和增殖。  |  Xiao, Z., et al. 2024. Brain Res. 1830: 148796. PMID: 38341169
  10. EphB3受体的缺失可防止骨质疏松小鼠模型的骨质流失。  |  Rodríguez-Sosa, MR., et al. 2024. J Bone Miner Res. 39: 1008-1024. PMID: 38739682

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产品名称产品编号规格价格数量收藏夹

EphB3 抗体 (7E5)

sc-100299
100 µg/ml
RMB2504.00

Can sc-100299: EphB3 (7E5) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: cjMara
Thank you for your question. Yes, sc-100299: EphB3 (7E5) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Produced good immunoperoxidase membrane stainingProduced good immunoperoxidase membrane staining in formalin-fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date published: 2015-04-16
Rated 4 out of 5 by from Positive detection of endogenous EphB3 proteinPositive detection of endogenous EphB3 protein by WB using HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-04
Rated 5 out of 5 by from Publishable data obtained by WB and IHC usingPublishable data obtained by WB and IHC using mouse bone marrow. -SCBT Publication Review
Date published: 2015-02-16
Rated 5 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human EphB3 protein via Western Blot analysis. -SCBT QC
Date published: 2015-02-03
Rated 5 out of 5 by from An increase in signal was observed via WesternAn increase in signal was observed via Western Blot when comparing mouse EphB3 transfected 293T cells with those that have not been transfected to over express the protein of interest. -SCBT QC
Date published: 2015-01-19
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EphB3 抗体 (7E5) is rated 4.6 out of 5 by 5.
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