Date published: 2025-9-7

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Clusterin 抗体 (A-9): sc-166907

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说明书
  • Clusterin 抗体 A-9 是小鼠单克隆 IgG2a κ,Clusterin抗体, 在24篇文献中引用,规格为200 µg/ml
  • 针对氨基酸120-449的抗原,在Clusterin的C-terminus处映射,human来源
  • Clusterin 抗体 (A-9) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 Clusterin
  • 抗Clusterin抗体(A-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Clusterin (A-9): sc-166907免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP 是 Clusterin 抗体 (A-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Clusterin 抗体 (A-9) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Clusterin抗体(A-9)是一种IgG2a κ小鼠单克隆Clusterin抗体(也称为CLU抗体、KUB1抗体、APOJ抗体和载脂蛋白J抗体),可通过WB、IP、IF、IHC(P)和ELISA检测人源Clusterin蛋白。Clusterin抗体(A-9)既可作为非偶联的抗Clusterin抗体形式提供,也可作为多种偶联形式的抗Clusterin抗体提供,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Clusterin,也被称为补体溶解抑制剂(CLI)、载脂蛋白J(ApoJ)、硫酸化糖蛋白2(SGP2)、SP-40和睾酮抑制的前列腺信息素2(TRPM2),是一种分泌型、异二聚体糖蛋白,影响免疫调节、细胞粘附、转化、脂质运输、组织重塑、膜再循环和细胞-细胞相互作用。Clusterin被合成为449个氨基酸的多肽,翻译后被切割成Arg 227和Ser 228之间的内部键。两个亚基α和β通过二硫键连接。β亚基(也称为ApoJα)对应于残基23-227。α亚基(也称为ApoJβ)对应于残基228-449。Clusterin的过度表达在乳腺肿瘤进展的晚期似乎更为常见。Clusterin显著影响体内的β-淀粉样蛋白结构和神经毒性,并可能影响阿尔茨海默病的发病机理。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Clusterin 抗体 (A-9) 参考文献:

  1. 载脂蛋白 J/clusterin 可预防衰老引起的渐进性肾小球病变。  |  Rosenberg, ME., et al. 2002. Mol Cell Biol. 22: 1893-902. PMID: 11865066
  2. 细胞死亡蛋白--核集束蛋白的合成与功能分析。  |  Leskov, KS., et al. 2003. J Biol Chem. 278: 11590-600. PMID: 12551933
  3. 作为小鼠和人类肠道肿瘤生物标志物的群集素  |  Chen, X., et al. 2003. Proc Natl Acad Sci U S A. 100: 9530-5. PMID: 12886021
  4. 人类结肠肿瘤发生过程中不同群集素异构体的调节。  |  Pucci, S., et al. 2004. Oncogene. 23: 2298-304. PMID: 14755245
  5. 压力诱导缺血后大鼠视网膜 Müller 细胞中簇蛋白的表达。  |  Gwon, JS., et al. 2004. Glia. 47: 35-45. PMID: 15139011
  6. 人类卵巢癌中细胞质群集素的上调表达。  |  Xie, D., et al. 2005. Cancer. 103: 277-83. PMID: 15578711
  7. 胰岛素样生长因子-1受体/Src/MAPK/Egr-1信号传导的延迟激活可调控簇蛋白的表达,而簇蛋白是一种促生存因子。  |  Criswell, T., et al. 2005. J Biol Chem. 280: 14212-21. PMID: 15689620
  8. Clusterin 通过与活化的 Bax 相互作用来抑制细胞凋亡。  |  Zhang, H., et al. 2005. Nat Cell Biol. 7: 909-15. PMID: 16113678
  9. 载脂蛋白 J:结构和组织分布。  |  de Silva, HV., et al. 1990. Biochemistry. 29: 5380-9. PMID: 1974459

订购信息

产品名称产品编号规格价格数量收藏夹

Clusterin 抗体 (A-9)

sc-166907
200 µg/ml
RMB2377.00

Clusterin (A-9): m-IgG Fc BP-HRP 套装

sc-529083
200 µg Ab; 10 µg BP
RMB2662.00

Clusterin (A-9): m-IgGκ BP-HRP 套装

sc-521794
200 µg Ab, 40 µg BP
RMB2662.00

Clusterin 抗体 (A-9) AC

sc-166907 AC
500 µg/ml, 25% agarose
RMB3129.00

Clusterin 抗体 (A-9) HRP

sc-166907 HRP
200 µg/ml
RMB2377.00

Clusterin 抗体 (A-9) FITC

sc-166907 FITC
200 µg/ml
RMB2482.00

Clusterin 抗体 (A-9) PE

sc-166907 PE
200 µg/ml
RMB2580.00

Clusterin 抗体 (A-9) Alexa Fluor® 488

sc-166907 AF488
200 µg/ml
RMB2685.00

Clusterin 抗体 (A-9) Alexa Fluor® 546

sc-166907 AF546
200 µg/ml
RMB2685.00

Clusterin 抗体 (A-9) Alexa Fluor® 594

sc-166907 AF594
200 µg/ml
RMB2685.00

Clusterin 抗体 (A-9) Alexa Fluor® 647

sc-166907 AF647
200 µg/ml
RMB2685.00

Clusterin 抗体 (A-9) Alexa Fluor® 680

sc-166907 AF680
200 µg/ml
RMB2685.00

Clusterin 抗体 (A-9) Alexa Fluor® 790

sc-166907 AF790
200 µg/ml
RMB2685.00

Is there a blocking peptide available for this product?

Asked by: AbPolly
Thank you for your question. This antibody is raised against a recombinant protein and not a short peptide sequence, so it is not possible to design a blocking peptide for it.
Answered by: Technical Support 13
Date published: 2017-02-09
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Rated 2 out of 5 by from Non molto buono per immunoistochimica!Ho testato questo anticorpo per immunoistochimica su campioni paraffinati ma ho ottenuto un segnale diffuso e non distinguibile dal background. Non sono molto soddisfatta!
Date published: 2021-04-13
Rated 5 out of 5 by from IHC(P)染色效果不错!很久以前用了该抗体进行石蜡切片免疫组化染色,稀释度1:400,染色效果不错! 阳性对照扁桃体树突细胞。
Date published: 2019-01-19
Rated 5 out of 5 by from Great Clusterin detectionWorks very well for the detection of human Clusterin. WB bands are clear and specific while IHC staining is bright and strong. This product has been cited over 10 times.
Date published: 2017-01-27
Rated 4 out of 5 by from WB with human serumWB with human serum. -SCBT Publication Review
Date published: 2015-04-13
Rated 5 out of 5 by from Beautiful immunoperoxidase cytoplasmic andBeautiful immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-04-10
Rated 5 out of 5 by from Worked well for western blotting with humanWorked well for western blotting with human breast cancer and healthy serum. -SCBT Publication Review
Date published: 2015-04-10
Rated 5 out of 5 by from Strong clear band in mouse transfected 293TStrong clear band in mouse transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-25
Rated 5 out of 5 by from Published western blot and IF data usingPublished western blot and IF data using human lung epithelial cells(A549). -SCBT Publication Review
Date published: 2015-02-11
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Clusterin 抗体 (A-9) is rated 4.5 out of 5 by 8.
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