Date published: 2025-9-7
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beta-catenin Antibody (12F7) - Western Blotting - Image 353134
β-catenin 抗体 (12F7): sc-59737. Western 印迹分析 A-431 全细胞裂解液中 β-catenin 的表达.
β-catenin 抗体 (12F7): sc-59737. Western 印迹分析 A-431 全细胞裂解液中 β-catenin 的表达.

beta-catenin 抗体 (12F7): sc-59737

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说明书
  • beta-catenin抗体(12F7)是小鼠单克隆IgG1 κ, 在119篇文献中引用，规格为200 µg/ml
  • 针对human起源的重组β-catenin
  • 抗-beta-catenin 抗体 (12F7) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 β-catenin
  • 抗beta-catenin抗体（12F7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取beta-catenin (12F7): sc-59737的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 beta-catenin 抗体 (12F7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与beta-catenin 抗体 (12F7) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Catenin 抗体包括 α E-catenin, α T-catenin, β-catenin, δ-catenin 和 γ-catenin

β-catenin 抗体 (12F7) 是一种针对重组人β-catenin开发的小鼠单克隆IgG1 kappa轻链抗体，可有效检测小鼠、大鼠和人类来源的β-catenin，适用于蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）等应用。抗-β-catenin抗体（12F7）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物，能够满足各种实验需求。β-catenin，也称为catenin beta-1或CTNNB1，是一种多功能蛋白，与细胞粘附和基因转录调控密切相关。β-catenin的翻译后修饰（PTMs），如磷酸化、泛素化和乙酰化，对于功能和调节至关重要。GSK-3β和CK1等激酶对特定丝氨酸和苏氨酸残基的磷酸化会导致β-catenin被β-TrCP泛素连接酶识别，从而标记β-catenin进行蛋白酶体降解，进而调节细胞质水平。相反，这些位点的去磷酸化或突变会导致β-catenin的稳定、积累和向细胞核的转移，β-catenin在细胞核中与TCF/LEF转录因子相互作用，调节细胞增殖和分化相关的基因表达。β-catenin的PTM失调与多种癌症有关，这凸显了这些修饰在维持细胞稳态中的重要性。β-catenin (12F7)抗体是研究人员研究这些关键细胞过程不可或缺的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

订购信息

产品名称产品编号规格价格数量收藏夹

beta-catenin 抗体 (12F7)

sc-59737
200 µg/ml
RMB2377.00

beta-catenin (12F7): m-IgG Fc BP-HRP 套装

sc-526942
200 µg Ab; 10 µg BP
RMB2662.00

beta-catenin (12F7): m-IgG1 BP-HRP 套装

sc-532315
200 µg Ab; 20 µg BP
RMB2662.00

beta-catenin 抗体 (12F7) AC

sc-59737 AC
500 µg/ml, 25% agarose
RMB3129.00

beta-catenin 抗体 (12F7) HRP

sc-59737 HRP
200 µg/ml
RMB2377.00

beta-catenin 抗体 (12F7) FITC

sc-59737 FITC
200 µg/ml
RMB2482.00

beta-catenin 抗体 (12F7) PE

sc-59737 PE
200 µg/ml
RMB2580.00

beta-catenin 抗体 (12F7) Alexa Fluor® 488

sc-59737 AF488
200 µg/ml
RMB2685.00

beta-catenin 抗体 (12F7) Alexa Fluor® 546

sc-59737 AF546
200 µg/ml
RMB2685.00

beta-catenin 抗体 (12F7) Alexa Fluor® 594

sc-59737 AF594
200 µg/ml
RMB2685.00

beta-catenin 抗体 (12F7) Alexa Fluor® 647

sc-59737 AF647
200 µg/ml
RMB2685.00

beta-catenin 抗体 (12F7) Alexa Fluor® 680

sc-59737 AF680
200 µg/ml
RMB2685.00

beta-catenin 抗体 (12F7) Alexa Fluor® 790

sc-59737 AF790
200 µg/ml
RMB2685.00

规格是多少？

Asked by: kathy卉
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Where is the epitope of this antibody?

Asked by: enger
Thank you for your question. This antibody was raised against a recombinant β-catenin of human origin. The exact binding epitope has not been mapped. If you have any further questions, please contact your local distributor, or technical service.
Answered by: Tech Service
Date published: 2019-08-13

Can β-catenin Antibody (12F7): sc-59737 be used in IHC with FFPE?

Asked by: jenni
Thank you for your inquiry. Yes, our β-catenin antibody sc-59737 is validated for use in IHC with formalin fixed, paraffin-embedded tissue sections. We recommend performing antigen retrieval with sodium citrate buffer, pH 6, and heat. The complete protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support 2
Date published: 2017-01-09
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Rated 5 out of 5 by from Review of β-catenin(Sc-59737) antibodyThe β-catenin (Sc-59737) antibody was used for western blot analysis. The product origin is mouse. The product was very good enough to get a clear band. I would strongly recommend this antibody for other users too.
Date published: 2020-08-20
Rated 5 out of 5 by from IMPECABLE!!! muy recomendable!!!!Muy buena marca en los diferentes tejidos utilizados
Date published: 2019-03-14
Rated 5 out of 5 by from Not quite suitable for wb of rat protein1：200 diluted for wb of rat heart protein,the band is a little weak
Date published: 2019-02-25
Rated 4 out of 5 by from Good antibodyI got a free sample a few month ago. For western-blot, the bands were really strong and clear.
Date published: 2018-09-28
Rated 4 out of 5 by from Good productI got a free sample from company. I used antibodies in WB in dilution 1:1000. It works good.
Date published: 2018-07-14
Rated 4 out of 5 by from WB实验我在12月初申请了小包装的试用装，非常感谢santa公司的慷慨提供，试用装效果还可以，稀释比例可按照1:500-1000；
Date published: 2018-01-02
Rated 5 out of 5 by from very nice bandthe antibody was tested on rat tissue samples and worked perfectly
Date published: 2017-12-13
Rated 4 out of 5 by from b-cateninI used this antibody for detection of b-catenin by western blot
Date published: 2017-09-18
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beta-catenin 抗体 (12F7) is rated 4.8 out of 5 by 22.
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