Date published: 2025-9-8

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Bek/FGFR2 抗体 (C-8): sc-6930

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说明书
  • Bek/FGFR2 抗体 C-8 是小鼠单克隆 IgG2b κ,Bek/FGFR2抗体, 在43篇文献中引用,规格为200 µg/ml
  • 特定用于C-terminus的805-821与Bek的human起源(与相应的鼠序列相同)之间的氨基酸表位图谱
  • Bek/FGFR2 抗体 (C-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Bek
  • 抗Bek/FGFR2抗体(C-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Bek/FGFR2 (C-8): sc-6930免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRPm-IgGκ BP-HRP 是 Bek/FGFR2 抗体 (C-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Bek/FGFR2 抗体 (C-8) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Bek 抗体(C-8)是一种小鼠单克隆 IgG2b kappa 轻链抗体,靶向成纤维细胞生长因子受体 2(FGFR2),也称为 Bek,这是一种重要的受体酪氨酸激酶,通过成纤维细胞生长因子(FGF)信号通路参与调节细胞增殖、分化、血管生成等细胞过程。FGFR2位于细胞表面,与FGF配体结合,启动一系列细胞内信号传导活动,这些活动对于组织发育、修复和维护至关重要。FGFR2的结构包括一个细胞外配体结合域、一个单跨膜螺旋和一个细胞内酪氨酸激酶域,这些结构对于其在信号转导中的作用以及与下游信号分子(如FRS2和PLCγ)的相互作用至关重要。FGFR2经历翻译后修饰,包括糖基化,这对于其正确折叠、稳定性和功能激活至关重要,从而增强其与特定细胞内伴侣相互作用的能力。FGFR2 单克隆抗体(C-8)可特异性识别 FGFR2 C 末端 805-821 氨基酸之间的表位,该区域在人类和小鼠序列中是保守的,可确保在小鼠、大鼠和人类等物种间进行可靠的检测。FGFR2单克隆抗体(C-8)用途广泛,推荐用于蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附测定(ELISA)。此外,FGFR2单克隆抗体(C-8)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物,可满足各种实验需求。FGFR2单克隆抗体(C-8)能够精确检测和分析FGFR2,是研究生长因子信号传导机制及其在发育生物学和疾病病理学中作用的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bek/FGFR2 抗体 (C-8) 参考文献:

  1. 通过短同源介导的重组删除 K-sam/FGFR2 的羧基末端外显子,产生特定信使 RNA 的优先表达。  |  Ueda, T., et al. 1999. Cancer Res. 59: 6080-6. PMID: 10626794
  2. 成纤维细胞生长因子受体 2 表达的负自调节是阿博特(P253R 突变)和普菲弗(C278F 突变)综合征病例颅骨发育的特征,并提出了他们颅骨表型差异的基础。  |  Britto, JA., et al. 2001. J Neurosurg. 95: 660-73. PMID: 11596961
  3. 小鼠 BEK 成纤维细胞生长因子(FGF)受体的特征:FGF 家族三个成员的激活和肝素的要求。  |  Mansukhani, A., et al. 1992. Proc Natl Acad Sci U S A. 89: 3305-9. PMID: 1373495
  4. 小鼠成纤维细胞生长因子受体2(bek/KGFR)基因的启动子区域。  |  Avivi, A., et al. 1992. Oncogene. 7: 1957-62. PMID: 1408137
  5. 在Hct-8、Hep-2、人类成纤维细胞、BEK和Vero培养细胞中培养贝氏疟原虫。  |  Siripanth, C., et al. 2004. Southeast Asian J Trop Med Public Health. 35: 796-800. PMID: 15916071
  6. 克隆和表达与酸性和碱性成纤维细胞生长因子交叉反应的两种不同的高亲和力受体。  |  Dionne, CA., et al. 1990. EMBO J. 9: 2685-92. PMID: 1697263
  7. 碱性成纤维细胞生长因子细胞生物学的最新发展。  |  Rifkin, DB. and Moscatelli, D. 1989. J Cell Biol. 109: 1-6. PMID: 2545723
  8. N-糖基化对在毕赤酵母中表达的重组bEKL的生化性质的影响。  |  Wang, Z., et al. 2018. Enzyme Microb Technol. 114: 40-47. PMID: 29685352
  9. 人胃癌细胞培养液中的可溶性 K-sam/FGFR2 蛋白。  |  Kishi, T., et al. 1994. Biochem Biophys Res Commun. 202: 1387-94. PMID: 8060318
  10. 成纤维细胞生长因子受体2前mRNA选择性剪接中BEK和K-SAM剪接位点的控制。  |  Gilbert, E., et al. 1993. Mol Cell Biol. 13: 5461-8. PMID: 8355693
  11. 大鼠肝脏发生和再生过程中成纤维细胞生长因子受体flg和bek的表达。  |  Hu, Z., et al. 1995. Cell Growth Differ. 6: 1019-25. PMID: 8547216
  12. FGFR2 BEK和K-SAM mRNA变异体在正常和恶性人类乳腺中的表达。  |  Luqmani, YA., et al. 1996. Eur J Cancer. 32A: 518-24. PMID: 8814701

订购信息

产品名称产品编号规格价格数量收藏夹

Bek/FGFR2 抗体 (C-8)

sc-6930
200 µg/ml
RMB2377.00

Bek/FGFR2 (C-8): m-IgGκ BP-HRP 套装

sc-520479
200 µg Ab, 40 µg BP
RMB2662.00

Bek/FGFR2 (C-8): m-IgG2b BP-HRP 套装

sc-548831
200 µg Ab; 10 µg BP
RMB2662.00

Bek/FGFR2 抗体 (C-8) AC

sc-6930 AC
500 µg/ml, 25% agarose
RMB3129.00

Bek/FGFR2 抗体 (C-8) HRP

sc-6930 HRP
200 µg/ml
RMB2377.00

Bek/FGFR2 抗体 (C-8) FITC

sc-6930 FITC
200 µg/ml
RMB2482.00

Bek/FGFR2 抗体 (C-8) PE

sc-6930 PE
200 µg/ml
RMB2580.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 488

sc-6930 AF488
200 µg/ml
RMB2685.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 546

sc-6930 AF546
200 µg/ml
RMB2685.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 594

sc-6930 AF594
200 µg/ml
RMB2685.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 647

sc-6930 AF647
200 µg/ml
RMB2685.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 680

sc-6930 AF680
200 µg/ml
RMB2685.00

Bek/FGFR2 抗体 (C-8) Alexa Fluor® 790

sc-6930 AF790
200 µg/ml
RMB2685.00

Bek/FGFR2 (C-8) 中和勝肽

sc-6930 P
100 µg/0.5 ml
RMB511.00

can this antibody be used in chicken? can you send me the sequence please?

Asked by: fernada
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-02-17

Can this antibody be used to detect Bek of canine origin?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 9
Date published: 2017-01-16

What is the difference between sc-6930 and sc-6930 P?

Asked by: AbPolly
Thank you for your inquiry. sc-6930 is our standard unconjugated Bek (C-8) monoclonal antibody. sc-6930 P is the blocking peptide matching this antibody that can be used as a negative control in combination with the antibody. For the protocol on how to use the blocking peptide, please see here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Service
Date published: 2016-12-23
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Rated 5 out of 5 by from バンドの差が確認できましたデータシートには、2本のバンドの画像がありますが、サイズ的には上のバンドが目的のバンドかと考えています。他のレビュアーの方のバンドと同じでした。
Date published: 2021-11-30
Rated 4 out of 5 by from good WB result on human VSMCsClean background, but only one band showed up in my blot
Date published: 2017-07-19
Rated 5 out of 5 by from it is a goodI would recommend this antibody for WB, the results are good and high specificity,
Date published: 2017-05-22
Rated 2 out of 5 by from Bek AntibodyThe antibody is not very good. The Bek couldn't be detected in 293T-Bek stable cell lines.
Date published: 2017-03-12
Rated 5 out of 5 by from Good AntibodyBek (C-8) performs well for WB and IHC(P). Recommend human skin tissue as positive control.
Date published: 2016-12-22
Rated 4 out of 5 by from Works well in WBWorks well in WB, correct MW band at 1:500.
Date published: 2015-10-06
Rated 5 out of 5 by from Produced superb immunoperoxidase cytoplasmicProduced superb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human skin tissue. -SCBT QC
Date published: 2015-05-09
Rated 5 out of 5 by from IP: Great results with NIH3T3 and HeLa cell linesIP: Great results with NIH3T3 and HeLa cell lines. -SCBT Publication Review
Date published: 2015-04-09
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Bek/FGFR2 抗体 (C-8) is rated 4.5 out of 5 by 11.
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