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AMPKβ2 抗体 (F-8): sc-376897

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说明书
  • AMPKβ2抗体(F-8)是小鼠单克隆IgA (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列1-75位于human物种的AMPKβ2的N-terminus
  • 推荐用于 mouse, rat 和 human 来源的AMPKβ2 WB, IP, IF 和 ELISA检测
  • 目前,我们还没有完成AMPKβ2 抗体 (F-8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    AMPK(5'-AMP-激活蛋白激酶)是一种由催化α亚基和调节β和γ亚基组成的异三聚体复合物。它通过关闭ATP消耗的生物合成途径来保护细胞免受导致ATP耗竭的应激。AMPK通过涉及变构调节的机制、由称为AMPK激酶的上游蛋白激酶促进磷酸化和抑制去磷酸化而由高AMP和低ATP激活。活化的AMPK可以在体内磷酸化和调节羟甲基戊二酰辅酶A还原酶和乙酰辅酶A羧化酶,它们分别是固醇合成和脂肪酸合成的关键调节酶。人类AMPKα1和AMPKα2基因分别编码548个氨基酸和552个氨基酸的蛋白质。人类AMPKβ1编码271个氨基酸的蛋白质,人类AMPKβ2编码272个氨基酸的蛋白质。人类AMPKγ1基因编码331个氨基酸的蛋白质。人类AMPKγ2和AMPKγ3分别含有569个和492个氨基酸的蛋白质,它们含有独特的N-末端结构域,并可能直接参与AMPK复合物中AMP的结合。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    AMPKβ2 抗体 (F-8) 参考文献:

    1. AMP激活蛋白激酶α2-异构体在心脏对无血流缺血的代谢反应中的作用  |  Zarrinpashneh, E., et al. 2006. Am J Physiol Heart Circ Physiol. 291: H2875-83. PMID: 16877552
    2. 通过 ADIPOR1-AMPK 途径控制正常大鼠和糖尿病大鼠肾远端小管中的糖原合酶。  |  Cammisotto, PG., et al. 2008. Am J Physiol Renal Physiol. 294: F881-9. PMID: 18256313
    3. AMPKβ 亚基:在 AMPK 复合物的形成过程中不仅仅是一个支架。  |  Sanz, P., et al. 2013. FEBS J. 280: 3723-33. PMID: 23721051
    4. 含有β2调节亚基的AMP激活蛋白激酶复合物在脂肪生成过程中上调,并促进脂肪生成。  |  Katwan, OJ., et al. 2019. Biochem J. 476: 1725-1740. PMID: 31189568
    5. 尼可刹米能独立于 AMP 激活含有 β2 亚基的 AMP 激活蛋白激酶复合物。  |  Suzuki, T., et al. 2020. Biochem Biophys Res Commun. 533: 758-763. PMID: 32993962
    6. 槲皮素通过调节肉鸡肠道微生物和 AMPK/PPAR 信号通路对脂质代谢的影响  |  Wang, M., et al. 2021. Front Cell Dev Biol. 9: 616219. PMID: 33634119
    7. TNF 诱导的坏死通过 RIPK3 依赖性 AMPK 激活启动早期自噬事件,但抑制晚期自噬。  |  Wu, W., et al. 2021. Autophagy. 17: 3992-4009. PMID: 33779513
    8. 2 型糖尿病患者骨骼肌细胞的特异性差异。  |  Frankenberg, NT., et al. 2022. Cell Mol Life Sci. 79: 256. PMID: 35460430
    9. AMP 激活的蛋白激酶 β1 或 β2 缺失可促进结肠癌细胞的生长和肿瘤发生。  |  Shi, F., et al. 2022. Acta Biochim Biophys Sin (Shanghai). 54: 1140-1147. PMID: 35880569
    10. 抑制神经元 AMPKβ2 同工酶会损害识别记忆和突触可塑性。  |  Swift, NA., et al. 2024. Neurobiol Dis. 201: 106664. PMID: 39278510

    订购信息

    产品名称产品编号规格价格数量收藏夹

    AMPKβ2 抗体 (F-8)

    sc-376897
    200 µg/ml
    $316.00

    I need to use an antibody to detect the protein in samples of porcine origin. Do you know if AMPKβ2 (F-8): sc-376897 mouse monoclonal antibody will work?

    Asked by: AbPolly
    Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Strong band in WB in human skeletal muscleStrong band in WB in human skeletal muscle tissue extract. -SCBT QC
    Date published: 2015-03-13
    Rated 5 out of 5 by from Good band in WB in human AMPK 2 transfectedGood band in WB in human AMPK 2 transfected 293T whole cell lysate and rat skeletal muscle tissue extract. -SCBT QC
    Date published: 2014-03-07
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    AMPKβ2 抗体 (F-8) is rated 5.0 out of 5 by 2.
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