Date published: 2025-9-7

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AMPKβ2 抗体 (C-7): sc-376752

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说明书
  • AMPK beta 2 抗体 C-7 是小鼠单克隆 IgG2a κ,AMPKβ2抗体, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列1-75位于human物种的AMPKβ2的N-terminus
  • AMPK beta 2 抗体 (C-7) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 AMPKβ2
  • 抗AMPK beta 2抗体(C-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取AMPKβ2 (C-7): sc-376752免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是AMPKβ2 Antibody (C-7) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与AMPKβ2 Antibody (C-7) 打包提供(请参阅下面的订购信息)。

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関連項目

AMPKβ2抗体(C-7)是一种IgG2aκ小鼠单克隆AMPK beta 2抗体(也称为AMPKβ2抗体),它通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的AMPK beta 2蛋白。AMPKβ2抗体(C-7)既可作为非偶联的抗AMPK beta 2抗体形式存在,也可作为多种偶联形式的抗AMPK beta 2抗体存在,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。AMPK(5'-AMP-激活蛋白激酶)是一种由催化α亚基和调节β和γ亚基组成的异三聚体复合物。它通过关闭ATP消耗的生物合成途径来保护细胞免受导致ATP耗竭的应激。AMPK通过涉及变构调节的机制、由称为AMPK激酶的上游蛋白激酶促进磷酸化和抑制去磷酸化而由高AMP和低ATP激活。活化的AMPK可以在体内磷酸化和调节羟甲基戊二酰辅酶A还原酶和乙酰辅酶A羧化酶,它们分别是固醇合成和脂肪酸合成的关键调节酶。人类AMPKα1和AMPKα2基因分别编码548个氨基酸和552个氨基酸的蛋白质。人类AMPKβ1编码271个氨基酸的蛋白质,人类AMPKβ2编码272个氨基酸的蛋白质。人类AMPKγ1基因编码331个氨基酸的蛋白质。人类AMPKγ2和AMPKγ3分别是569和492个氨基酸的蛋白质,它们含有独特的N-末端结构域,并可能直接参与AMPK复合物中AMP的结合。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

AMPKβ2 抗体 (C-7) 参考文献:

  1. AMP 活化蛋白激酶 gamma 亚基同工酶的特征及其在 AMP 结合中的作用。  |  Cheung, PC., et al. 2000. Biochem J. 346 Pt 3: 659-69. PMID: 10698692
  2. 双杂交分析发现蛋白酶体的非ATP酶亚基PSMD11是AMP激活的蛋白激酶的新型相互作用伙伴。  |  Moreno, D., et al. 2009. Int J Biochem Cell Biol. 41: 2431-9. PMID: 19616115
  3. 各种间充质细胞类型中 AMP 激活蛋白激酶亚基的基因表达谱和磷酸化模式。  |  Wang, Y., et al. 2014. Chin Med J (Engl). 127: 2451-7. PMID: 24985582
  4. AMPKβ2与PP1靶向亚基R6之间的相互作用受细胞内糖原含量的动态调节。  |  Oligschlaeger, Y., et al. 2016. Biochem J. 473: 937-47. PMID: 26831516
  5. 牛磺酸上调基因1作为主调节因子协调肝细胞癌中的糖酵解和转移。  |  Lin, YH., et al. 2018. Hepatology. 67: 188-203. PMID: 28802060
  6. 性别和纤维类型对人体静息状态和高强度运动恢复期间的 AMPK、TBC1D1 和 TBC1D4 有独立影响。  |  Tobias, IS., et al. 2020. J Appl Physiol (1985). 128: 350-361. PMID: 31895596
  7. AMPKβ1和AMPKβ2在人类多能干细胞中定义了一种同工酶特异性基因特征,以不同方式介导心系的形成。  |  Ziegler, N., et al. 2020. J Biol Chem. 295: 17659-17671. PMID: 33454005
  8. 运动训练可减轻免疫介导的坏死性肌病和皮肌炎患者的骨骼肌脂肪浸润,改善胰岛素通路。  |  de Oliveira, DS., et al. 2023. Arch Rheumatol. 38: 189-199. PMID: 37680507
  9. 哺乳动物 AMP 激活蛋白激酶亚家族。  |  Stapleton, D., et al. 1996. J Biol Chem. 271: 611-4. PMID: 8557660
  10. AMP-活化蛋白激酶--哺乳动物细胞的燃料调节器?  |  Hardie, DG. and Carling, D. 1997. Eur J Biochem. 246: 259-73. PMID: 9208914
  11. AMP激活的蛋白激酶同工酶家族:亚基结构和染色体位置。  |  Stapleton, D., et al. 1997. FEBS Lett. 409: 452-6. PMID: 9224708
  12. 鉴定在骨骼肌中高表达的新型 AMP 激活蛋白激酶 beta 亚基同工酶。  |  Thornton, C., et al. 1998. J Biol Chem. 273: 12443-50. PMID: 9575201

订购信息

产品名称产品编号规格价格数量收藏夹

AMPKβ2 抗体 (C-7)

sc-376752
200 µg/ml
$316.00

AMPKβ2 (C-7): m-IgGκ BP-HRP 套装

sc-523082
200 µg Ab, 40 µg BP
$354.00

AMPKβ2 (C-7): m-IgG2a BP-HRP 套装

sc-546142
200 µg Ab; 10 µg BP
$354.00

AMPKβ2 抗体 (C-7) AC

sc-376752 AC
500 µg/ml, 25% agarose
$416.00

AMPKβ2 抗体 (C-7) HRP

sc-376752 HRP
200 µg/ml
$316.00

AMPKβ2 抗体 (C-7) FITC

sc-376752 FITC
200 µg/ml
$330.00

AMPKβ2 抗体 (C-7) PE

sc-376752 PE
200 µg/ml
$343.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 488

sc-376752 AF488
200 µg/ml
$357.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 546

sc-376752 AF546
200 µg/ml
$357.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 594

sc-376752 AF594
200 µg/ml
$357.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 647

sc-376752 AF647
200 µg/ml
$357.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 680

sc-376752 AF680
200 µg/ml
$357.00

AMPKβ2 抗体 (C-7) Alexa Fluor® 790

sc-376752 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of equine origin. Do you know if sc-376752: AMPKβ2 (C-7) mouse monoclonal antibody will work?

Asked by: Trav11
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
  • y_2025, m_9, d_7, h_4CST
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Rated 4 out of 5 by from Good antibody for WBWe can see the band. Application: WB Sample: rat microglia culture
Date published: 2020-08-25
Rated 5 out of 5 by from Great featuresI applied an sample a month ago, and so happy that I did Weatern blot(dilution 1:100),I am very satified with the result.
Date published: 2017-08-17
Rated 5 out of 5 by from Excellent antibody for Western blotting.This product has been independently tested and validated in-house at Kinexus Bioinformatics Corporation as a very potent and highly specific antibody for Western blotting with in diverse human cell lines. It strongly detects an appropriately sized target 30 kDa protein in immunoblots of a mix of HeLa and Jurkat cell lysates, but does show cross-reactivity with an unidentified ~120 kDa protein.
Date published: 2016-10-13
Rated 5 out of 5 by from Strong band in WB in human skeletal muscleStrong band in WB in human skeletal muscle tissue extract. -SCBT QC
Date published: 2015-05-12
Rated 5 out of 5 by from Strong signal in WB in rat skeletal muscleStrong signal in WB in rat skeletal muscle tissue extract and HeLa whole cell lysate. -SCBT QC
Date published: 2013-10-20
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AMPKβ2 抗体 (C-7) is rated 4.8 out of 5 by 5.
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