SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | ¥305.00 ¥429.00 ¥1106.00 ¥3069.00 | 28 | |
竞争性抑制多种阴离子转运蛋白,可能降低SLC17家族成员的功能。 | ||||||
Phloridzin | 60-81-1 | sc-219613 | 2.5 g | ¥4377.00 | ||
抑制钠依赖性转运蛋白,可能降低磷酸盐的竞争性摄取。 | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | ¥316.00 ¥417.00 | 18 | |
通过影响前列腺素的合成间接抑制阴离子转运蛋白,改变肾脏转运动力学。 | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | ¥451.00 | ||
一种抑制NKCC2的环孢利尿剂,可能对磷酸盐转运产生次要影响。 | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | ¥1207.00 ¥2527.00 | 9 | |
与呋塞米类似,抑制NKCC2,从而间接影响SLC17A活性。 | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | ¥2414.00 | ||
影响肌醇单磷酸酶,导致阴离子转运发生变化,从而改变SLC17A功能。 | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | ¥361.00 | ||
改变脂质代谢,并通过改变膜特性影响膜转运蛋白。 | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | ¥609.00 ¥2651.00 ¥3678.00 ¥6216.00 ¥10932.00 | ||
一种影响电解质重吸收的噻嗪类利尿剂,可能间接影响与SLC17A相关的转运。 | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | ¥429.00 ¥1185.00 ¥1941.00 | ||
与氢氯噻嗪类似,可能通过改变离子平衡间接影响SLC17A活性。 |