Ste20 (sterile 20) Serine/Threonine Kinase (STK) 抑制因子

The GCK (Germinal Center Kinase) Group III family of kinases falls under the larger Ste20 (sterile 20) superfamily of serine/threonine kinases. This group is characterized by a distinct structural and functional profile, setting it apart within the Ste20 kinase superfamily. The Ste20 family itself is quite large, encompassing a broad array of kinases implicated in various cellular signaling pathways. These pathways are crucial for controlling a range of cellular functions, including cell growth, differentiation, death, and volume regulation. In humans, about 30 members of the Ste20 family have been identified, and the GCK Group III kinases are a notable subset of this family.

Small molecule inhibitors targeting the Ste20 (sterile 20) superfamily of serine/threonine kinases are designed to modulate the kinase activity of this diverse group of enzymes. The Ste20 family plays a pivotal role in a variety of cellular signaling pathways, influencing processes such as cell growth, differentiation, apoptosis, and cytoskeletal organization. By inhibiting these kinases, small molecules can alter the phosphorylation state of target proteins, thereby modulating the signaling pathways in which these kinases are involved. The specificity and efficacy of these inhibitors are crucial, as they need to selectively target the Ste20 kinases without affecting other serine/threonine kinases.