Scrib 抑制因子

Common Scrib Inhibitors include, but are not limited to Cyclopamine CAS 4449-51-8, DAPT CAS 208255-80-5, Vismodegib CAS 879085-55-9, IWP-2 CAS 686770-61-6 and XAV939 CAS 284028-89-3.

Scrib, also known as Scribble, is a scaffolding protein that plays a critical role in determining cell polarity and maintaining proper cellular architecture. It belongs to the LAP (LRR and PDZ) protein family and is characterized by the presence of 16 leucine-rich repeats (LRRs) and four PSD-95/Dlg/ZO-1 (PDZ) domains. Scrib is localized at the basolateral membrane of epithelial cells and is involved in various cellular processes, including cell-to-cell adhesion, migration, proliferation, and differentiation. Its primary function is to establish and maintain epithelial cell polarity, ensuring that cells are oriented correctly within tissues. Additionally, Scrib is known to interact with various proteins, forming complexes that mediate numerous signaling pathways, including the Hippo and Wnt signaling pathways.

Scrib inhibitors are molecules specifically designed to target and inhibit the function of the Scrib protein. Given the pivotal role of Scrib in cellular polarity and signaling, the inhibition of its activity can have profound effects on cellular behavior and organization. These inhibitors may bind directly to the Scrib protein or disrupt its interaction with binding partners, thereby affecting its role in signaling pathways and cell polarity establishment. The precise understanding and development of Scrib inhibitors arise from in-depth studies in molecular biology, biochemistry, and structural biology, aiming to elucidate the Scrib protein's exact mechanisms of action. By targeting Scrib, these inhibitors offer valuable insights into the protein's role in various cellular processes and help to understand the broader implications of modulating cell polarity and associated signaling pathways in different cellular contexts.