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XIAP 抗体 (D-2): sc-55552

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说明书
  • XIAP抗体(D-2)是小鼠单克隆IgG2b κ, 在15篇文献中引用,规格为200 µg/ml
  • 针对氨基酸1-202,在XIAP的human起源的N-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的XIAP WB, IP, IF 和 ELISA检测
  • 看 XIAP (A-7): sc-55550,可查看有标记的 XIAP 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是XIAP Antibody (D-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与XIAP Antibody (D-2) 打包提供(请参阅下面的订购信息)。
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杆状病毒蛋白p35可以抑制病毒诱导的无脊椎动物和哺乳动物细胞的凋亡,并可能通过破坏宿主免疫系统清除病毒感染细胞的功能来发挥作用。这至少部分是通过其抑制ICE家族丝氨酸蛋白酶的能力来阻断TNF和FAS介导的凋亡来实现的。杆状病毒p35的两个哺乳动物同源物,被称为凋亡抑制蛋白(IAP)1和2,共享一个氨基末端杆状病毒IAP重复(BIR)基序和一个羧基末端RING指结构。尽管c-IAPs不直接与TNF受体(TNF-R)结合,但它们通过与下游TNF-R效应器TRAF1和TRAF2的相互作用有效地阻断TNF介导的凋亡。IAP家族的其他成员包括XIAP和存活素。XIAP抑制活化的caspase-3,导致对FAS介导的凋亡产生抗性。存活素(也称为TIAP)在细胞周期的G2/M期表达,并与有丝分裂纺锤体的微管相关。当存活素-微管相互作用发生破坏时,可检测到caspase-3活性的增加。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

XIAP 抗体 (D-2) 参考文献:

  1. 人类XIAP缺陷综合征。  |  Latour, S. and Aguilar, C. 2015. Semin Cell Dev Biol. 39: 115-23. PMID: 25666262
  2. XIAP处于细胞死亡和炎症的交叉点。  |  Vucic, D. 2018. Oncotarget. 9: 27319-27320. PMID: 29937987
  3. 炎症动员铜代谢,通过 IL-17-STEAP4-XIAP 轴促进结肠肿瘤发生。  |  Liao, Y., et al. 2020. Nat Commun. 11: 900. PMID: 32060280
  4. XIAP在人类癌症中的概况。  |  Tu, H. and Costa, M. 2020. Biomolecules. 10: PMID: 33138314
  5. 我们对XIAP缺陷的理解的演变。  |  Mudde, ACA., et al. 2021. Front Pediatr. 9: 660520. PMID: 34222142
  6. XIAP作为细胞信号传导中的多面分子。  |  Hanifeh, M. and Ataei, F. 2022. Apoptosis. 27: 441-453. PMID: 35661061
  7. 槲皮素可改善与XIAP缺陷相关的过度炎症。  |  Chiang, SCC., et al. 2022. Blood. 140: 706-715. PMID: 35687753
  8. 在X连锁抑制细胞凋亡(XIAP)缺陷中,由Caspase-8驱动的凋亡和热解凋亡的相互作用会导致细胞死亡和IL-1β释放。  |  Hughes, SA., et al. 2023. EMBO J. 42: e110468. PMID: 36647737
  9. XIAP缺失使小鼠对TNF诱导和RIP1介导的死亡敏感。  |  Witt, A., et al. 2023. Cell Death Dis. 14: 262. PMID: 37041175
  10. XIAP介导的IFT88降解会破坏HSC纤毛,从而刺激HSC活化和肝纤维化。  |  Hong, R., et al. 2024. EMBO Rep. 25: 1055-1074. PMID: 38351372

订购信息

产品名称产品编号规格价格数量收藏夹

XIAP 抗体 (D-2)

sc-55552
200 µg/ml
CNY2422.00

XIAP (D-2): m-IgG Fc BP-HRP 套装

sc-537073
200 µg Ab; 10 µg BP
CNY2715.00

XIAP (D-2): m-IgGκ BP-HRP 套装

sc-534259
200 µg Ab; 40 µg BP
CNY2715.00

XIAP (D-2): m-IgG2b BP-HRP 套装

sc-549853
200 µg Ab; 10 µg BP
CNY2715.00

I need to use an antibody to detect the protein in samples of bovine origin. Do you know if sc-55552: XIAP (D-2) mouse monoclonal antibody will work?

Asked by: Randy McDonald
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 4 out of 5 by KG from Good specificity in WB in HeLa whole cellGood specificity in WB in HeLa whole cell lysate and mouse thymus and rat kidney tissue extracts. -SCBT QC
Date published: 2015-06-08
Rated 4 out of 5 by ET from Published for WB in human and mouse pancreaticPublished for WB in human and mouse pancreatic cells. -SCBT Publication Review
Date published: 2015-04-02
Rated 4 out of 5 by ET from Strong band in WB in human BxPCStrong band in WB in human BxPC-3 and PANC-1 cells. -SCBT Publication Review
Date published: 2015-02-22
Rated 4 out of 5 by JL from Positive signal in WB in human transfectedPositive signal in WB in human transfected 293T and A549 whole cell lysates. -SCBT QC
Date published: 2015-02-21
Rated 4 out of 5 by JT from Good publishable data in WB in human A549 cellsGood publishable data in WB in human A549 cells. -SCBT Publication Review
Date published: 2014-06-02
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XIAP 抗体 (D-2) is rated 4.0 out of 5 by 5.
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