Date published: 2025-9-8
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V-ATPase B2 Antibody (C-9) - Western Blotting - Image 356617
V-ATPase B2 抗体 (C-9): sc-166122. SK-N-SH (A), HeLa (B), c4 (C), RAW 264. 7 (D), L8 (E) 和 C6 (F) 全细胞裂解液中 V-ATPase B2 表达的 Western 印迹分析.
V-ATPase B2 抗体 (C-9): sc-166122. SK-N-SH (A), HeLa (B), c4 (C), RAW 264. 7 (D), L8 (E) 和 C6 (F) 全细胞裂解液中 V-ATPase B2 表达的 Western 印迹分析.

V-ATPase B2 抗体 (C-9): sc-166122

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说明书
  • V-ATPase B2抗体(C-9)是小鼠单克隆IgG3 κ, 在4篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的V-ATPase B2的N-terminus的氨基酸2-38之间
  • 推荐用于 mouse, rat 和 human 来源的V-ATPase B2 WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 canine and bovine
  • m-IgG3 BP-HRP是V-ATPase B2 Antibody (C-9) 适用于 WB 应用。 的首选辅助检测试剂，该试剂现与V-ATPase B2 Antibody (C-9) 搭配使用（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

附加V-ATPase抗体，包括V-ATPase A1, V-ATPase α 1, V-ATPase B1, V-ATPase B2, V-ATPase C1, V-ATPase C2, V-ATPase D, V-ATPase D1, V-ATPase D2, V-ATPase G1, V-ATPase G2和V-ATPase H

液泡型H+-ATP酶 (V-ATPase) 是一种多亚基酶，它负责酸化真核细胞内细胞器。V-ATP酶可以逆着电化学梯度泵送质子，而F-ATP酶则能逆转该过程，从而合成ATP。V-ATPase 由外周V1结构域和完整V0结构域组成，它们分别负责ATP水解和质子转运。V1结构域由九个亚基（A-H）组成，V0结构域由五个亚基（a、d、c、c'和c"）组成。V-ATP酶与F-ATP酶一样很可能通过旋转原理运转。V-ATPase V1 B亚基存在两种亚型。在内耳中，V-ATPase B1亚型在分泌质子中起作用，用以维持合适的内淋巴pH值和正常的听觉功能。编码人V-ATPase B1亚型的基因位于染色体2cen-q13。该基因发生突变会导致远端肾小管酸中毒，这与感音神经性耳聋相关。V-ATPase B2亚型在肾脏有表达，是破骨细胞中唯一能表达的B亚型。编码人V-ATPase B2亚型的基因位于染色体 8p22-p21。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

V-ATPase B2 抗体 (C-9) 参考文献:

  1. Rab GTPase 在小鼠肾脏中的分布以及与液泡 H+-ATPase 的比较  |  Curtis, LM. and Gluck, S. 2005. Nephron Physiol. 100: p31-42. PMID: 15838183
  2. V-ATPase B2亚基在缺乏B1亚基的小鼠附睾透明细胞顶膜上的重新定位。  |  Da Silva, N., et al. 2007. Am J Physiol Cell Physiol. 293: C199-210. PMID: 17392376
  3. B1缺陷小鼠肾髓质闰层细胞中V-ATP酶B2亚基同工酶的补偿膜表达  |  Paunescu, TG., et al. 2007. Am J Physiol Renal Physiol. 293: F1915-26. PMID: 17898041
  4. CFTR 和 ClC-5 在调节肾近曲小管空泡 H+-ATP 酶活性中的作用  |  Carraro-Lacroix, LR., et al. 2010. Cell Physiol Biochem. 26: 563-76. PMID: 21063094
  5. V-ATPase 促进转化生长因子-β 诱导的大鼠近端肾小管上皮细胞上皮-间质转化。  |  Cao, X., et al. 2012. Am J Physiol Renal Physiol. 302: F1121-32. PMID: 22129967
  6. V-ATPase B2 和（原）肾素受体在促进肾小管间质纤维化进程中的相互作用  |  Liu, Y., et al. 2016. Sci Rep. 6: 25035. PMID: 27121029
  7. V-ATP 酶受损会导致溶酶体 pH 值升高，造成溶酶体降解紊乱和自噬通量受阻，从而导致氟化物诱导的发育神经毒性。  |  Han, X., et al. 2022. Ecotoxicol Environ Saf. 236: 113500. PMID: 35421827
  8. 过表达 V-ATPase B2 可稳定溶酶体膜通透性并增加胶原降解，从而减轻肺损伤/纤维化。  |  Lee, JU., et al. 2022. Exp Mol Med. 54: 662-672. PMID: 35624153
  9. V-ATPase B2 通过使 MAPK 信号通路失活，促进小胶质细胞吞噬髓鞘碎片。  |  Li, Y., et al. 2024. Neuropeptides. 106: 102436. PMID: 38733728
  10. F-53B 通过抑制神经细胞中的 V-ATPase-AMPK 轴来破坏能量代谢。  |  Zhang, Y., et al. 2025. J Hazard Mater. 487: 137111. PMID: 39793390

订购信息

产品名称产品编号规格价格数量收藏夹

V-ATPase B2 抗体 (C-9)

sc-166122
200 µg/ml
RMB2377.00

V-ATPase B2 (C-9): m-IgG3 BP-HRP 套装

sc-550390
200 µg Ab; 40 µg BP
RMB2662.00

V-ATPase B2 (C-9) 中和勝肽

sc-166122 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-166122 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good Antibody for WBThis antibody is well-cited for a variety of applications including WB, IP, IF, and even ELISA. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2017-01-27
Rated 5 out of 5 by from Excellent immunofluorescence cytoplasmicExcellent immunofluorescence cytoplasmic and cytoplasmic vesicles staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-05-18
Rated 5 out of 5 by from Positive detection of endogenous VPositive detection of endogenous V-ATPase B2 expression in U-87 MG cells by WB. -SCBT QC
Date published: 2015-04-30
Rated 4 out of 5 by from An increase in signal was observed via WesternAn increase in signal was observed via Western Blot when comparing mouse V-ATPase B2 transfected 293T cells with those that have not been transfected. -SCBT QC
Date published: 2015-03-11
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V-ATPase B2 抗体 (C-9) is rated 4.8 out of 5 by 4.
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