Date published: 2025-9-7

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TRAF5 抗体 (E-5): sc-74503

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说明书
  • TRAF5抗体(E-5)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的TRAF5的氨基酸1-257
  • 推荐用于 mouse, rat 和 human 来源的TRAF5 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是TRAF5 Antibody (E-5) for WB applications. 的首选辅助检测试剂,这些试剂现与TRAF5 Antibody (E-5) 打包提供(请参阅下面的订购信息)。

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関連項目

TRAF5是TNF受体相关因子(TRAF)蛋白家族的成员。TRAF蛋白与TNF受体超家族成员相关并介导其信号转导。TRAF5是与CD40细胞质域相关的复合物的一个组成部分,介导TNF诱导的NF-kappa B激活并保护细胞免于死亡。TRAF5通过其他受体影响信号事件,包括CD27、CD30和淋巴毒素-β受体。TRAF5在破骨细胞生成中发挥作用。据报道,有两种编码相同蛋白的替代剪接转录变体。肿瘤坏死因子(TNF)受体超家族由几种I型整体膜糖蛋白组成,这些糖蛋白在其富含半胱氨酸的细胞外结构域中表现出同源性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TRAF5 抗体 (E-5) 参考文献:

  1. TRAF5 缺乏会增加炎症细胞的招募和泡沫细胞的形成,从而加速小鼠动脉粥样硬化的发生。  |  Missiou, A., et al. 2010. Circ Res. 107: 757-66. PMID: 20651286
  2. 肿瘤坏死因子受体相关因子 3(TRAF3)和 TRAF5 在免疫细胞功能中的作用。  |  Hildebrand, JM., et al. 2011. Immunol Rev. 244: 55-74. PMID: 22017431
  3. TRAF5 负向调节 B 淋巴细胞中的 TLR 信号。  |  Buchta, CM. and Bishop, GA. 2014. J Immunol. 192: 145-50. PMID: 24259503
  4. TRAF5和TRAF3IP2基因多态性与白塞氏病和Vogt-Koyanagi-Harada综合征相关:一项病例对照研究。  |  Xiang, Q., et al. 2014. PLoS One. 9: e84214. PMID: 24416204
  5. TRAF5 介导的 Lys-63 链接多泛素化在 RORγt 促进 IL-17A 表达的正向调节中发挥着重要作用。  |  Wang, X., et al. 2015. J Biol Chem. 290: 29086-94. PMID: 26453305
  6. TRAF5能促进骨髓祖细胞中质树突状细胞的发育。  |  Kobayashi, S., et al. 2020. Biochem Biophys Res Commun. 521: 353-359. PMID: 31668809
  7. 缺乏 TRAF5 会降低非造血细胞中 TRAF2 的表达,从而改善右旋糖酐硫酸钠结肠炎的严重程度。  |  Phung, HT., et al. 2020. Immunohorizons. 4: 129-139. PMID: 32156688
  8. TRAF5 可通过 AKT 信号传导防止心肌缺血再灌注损伤。  |  Xu, W., et al. 2020. Eur J Pharmacol. 878: 173092. PMID: 32234528
  9. TRAF5 通过激活 PI3K/AKT/NF-κB 信号通路促进结肠癌的发生和发展。  |  Sun, G., et al. 2020. J Biol Regul Homeost Agents. 34: 1257-1268. PMID: 32911926
  10. 通过抑制LTBR介导的NF-κB信号传导,沉默TRAF5可增强肝细胞癌的坏死。  |  Wu, G., et al. 2023. PeerJ. 11: e15551. PMID: 37366426

订购信息

产品名称产品编号规格价格数量收藏夹

TRAF5 抗体 (E-5)

sc-74503
200 µg/ml
RMB2377.00

TRAF5 (E-5): m-IgG Fc BP-HRP 套装

sc-539534
200 µg Ab; 10 µg BP
RMB2662.00

TRAF5 (E-5): m-IgG1 BP-HRP 套装

sc-541548
200 µg Ab; 20 µg BP
RMB2662.00

Are there any issues with using sc-74503: TRAF5 (E-5) mouse monoclonal primary antibody on mouse samples?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-74503 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Publishable data for IP and WB in MLE cellsPublishable data for IP and WB in MLE cells, human PBMCs, and U937 cells. -SCBT Publication Review
Date published: 2015-03-04
Rated 5 out of 5 by from Worked well in WB in HeLaWorked well in WB in HeLa, Jurkat and CTLL-2 whole cell lysates. -SCBT QC
Date published: 2015-01-24
Rated 5 out of 5 by from Publishable data for IP and WB in human HBECsPublishable data for IP and WB in human HBECs and MEFs. -SCBT Publication Review
Date published: 2013-08-23
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TRAF5 抗体 (E-5) is rated 5.0 out of 5 by 3.
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