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TLR9 Antibody (5G5) - Western Blotting - Image 11051
TLR9 抗体 (5G5): sc-47723. RAW 309 Cr. 1 全细胞裂解液中 TLR9 表达的 Western 印迹分析.
TLR9 Antibody (5G5) - Western Blotting - Image 11051
TLR9 抗体 (5G5): sc-47723. RAW 309 Cr. 1 全细胞裂解液中 TLR9 表达的 Western 印迹分析.
TLR9 抗体 (5G5): sc-47723. RAW 309 Cr. 1 全细胞裂解液中 TLR9 表达的 Western 印迹分析.

TLR9 抗体 (5G5): sc-47723

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寫評論提問

说明书
  • TLR9抗体(5G5)是小鼠单克隆IgG2a λ, 在17篇文献中引用，规格为100 µg/ml
  • 针对由TLR9 of human TLR9（残基1-815）组成的融合蛋白
  • 推荐用于 mouse, rat 和 human 来源的TLR9 WB, IP, IF, IHC(P) 和 FCM检测; 也和以下物种反应，包括： canine
  • 关于如何获取TLR9 (5G5): sc-47723的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成TLR9 抗体 (5G5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 TLR 抗体 包括 TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8和TLR9

TLR9抗体（5G5）是一种小鼠单克隆IgG抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测小鼠、大鼠和人类来源的TLR9蛋白。抗TLR9抗体（5G5）有非结合形式。TLR9蛋白在先天免疫系统中起着至关重要的作用，它能够识别细菌和病毒DNA中的特定未甲基化的CpG序列，这对于启动免疫反应至关重要。这种识别会触发多种信号通路的激活，包括NFκB通路，从而产生促炎细胞因子并激活适应性免疫。TLR9主要在免疫相关组织（如脾脏、淋巴结和骨髓）中表达，在这些组织中，TLR9有助于协调人体对病原体的防御。TLR9检测外来DNA的能力对于免疫系统区分自身和非自身至关重要，这使得TLR9成为维持免疫稳态和预防自身免疫性疾病的关键因素。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TLR9 抗体 (5G5) 参考文献:

  1. 微生物脂蛋白通过收费样受体触发的宿主防御机制。  |  Brightbill, HD., et al. 1999. Science. 285: 732-6. PMID: 10426995
  2. 三种新型哺乳动物收费样受体：基因结构, 表达和进化。  |  Du, X., et al. 2000. Eur Cytokine Netw. 11: 362-71. PMID: 11022119
  3. 克隆和鉴定人类收费样受体亚家族：hTLR7, hTLR8 和 hTLR9。  |  Chuang, TH. and Ulevitch, RJ. 2000. Eur Cytokine Netw. 11: 372-8. PMID: 11022120
  4. 果蝇 Toll 和 IL-1 受体  |  Gay, NJ. and Keith, FJ. 1991. Nature. 351: 355-6. PMID: 1851964
  5. 重新审视TLR9作为CLL治疗靶点。  |  Kortylewski, M. 2021. Blood. 137: 3006-3008. PMID: 34081121
  6. 双重靶向TLR9和PD-L1可释放树突状细胞，从而诱导持久的抗肿瘤免疫。  |  Fernandez-Rodriguez, L., et al. 2023. J Immunother Cancer. 11: PMID: 37208130
  7. 趋化因子CXCL4对TLR9配体的隔离对中央B细胞耐受产生负面影响。  |  Çakan, E., et al. 2023. J Exp Med. 220: PMID: 37773045
  8. 周期性棕榈酰化调节小鼠TLR9信号传导和系统性自身免疫。  |  Ni, H., et al. 2024. Nat Commun. 15: 1. PMID: 38169466
  9. 通过DNA感应TLR9通路形成记忆集合。  |  Jovasevic, V., et al. 2024. Nature. 628: 145-153. PMID: 38538785
  10. B细胞中的Tlr9缺陷通过促进炎症和肠道菌群失调导致肥胖。  |  Wang, P., et al. 2024. Nat Commun. 15: 4232. PMID: 38762479
  11. TLR7和TLR9在系统性硬化症发病机理中的作用。  |  Wang, C., et al. 2024. Int J Mol Sci. 25: PMID: 38892317
  12. 在结构上与果蝇 Toll 有关的人类受体家族。  |  Rock, FL., et al. 1998. Proc Natl Acad Sci U S A. 95: 588-93. PMID: 9435236

订购信息

产品名称产品编号规格价格数量收藏夹

TLR9 抗体 (5G5)

sc-47723
100 µg/ml
RMB2377.00

Can TLR9 (5G5): sc-47723 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TLR9 (5G5): sc-47723 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 3 out of 5 by from Tested on HFFF by FACSThis antibody was tested on HFFF cells by FACS and gave a mild signal, even at dilution 1:25
Date published: 2018-11-19
Rated 5 out of 5 by from Funktioniert sehr gut im Western Blot.Mit TLR8HA transfiziertes Hek-Lysat gestestet, parallel dazu mit anti-HA gefärbt, funtioniert sehr gut.
Date published: 2018-04-26
Rated 1 out of 5 by from TLR9 antibody(5G5)we used TLR9 Antibody (#47723) in Human Neutrophils. It did not work (no Band). the dilution was 1/200 in TBSTMilk5%
Date published: 2018-04-10
Rated 5 out of 5 by from Great WBThis antibody will provide the correct target bands in mouse, rat, and human samples. It works well in additional applications and has been published with multiple times.
Date published: 2017-02-02
Rated 4 out of 5 by from Good for western blot analysis of TLR9 expressionGood for western blot analysis of TLR9 expression in RAW 309 Cr.1 whole cell lysate. - SCBT QC
Date published: 2014-04-03
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TLR9 抗体 (5G5) is rated 3.6 out of 5 by 5.
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