Date published: 2025-9-7
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Tau Antibody (Tau-13) - Western Blotting - Image 380605
Tau 抗体 (Tau-13): sc-21796. Jurkat (A) 和 IMR-32 (B) 全细胞裂解液中 Tau 表达的 Western 印迹分析.
Tau 抗体 (Tau-13): sc-21796. Jurkat (A) 和 IMR-32 (B) 全细胞裂解液中 Tau 表达的 Western 印迹分析.

Tau 抗体 (Tau-13): sc-21796

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说明书
  • Tau抗体(Tau-13)是小鼠单克隆IgG1 κ, 在34篇文献中引用，规格为200 µg/ml
  • 针对human重组Tau
  • 抗-Tau 抗体 (Tau-13) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 all Tau isoforms; 不受Tau磷酸化抑制
  • 抗Tau抗体（Tau-13）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 另提供生物素偶联抗体，可用于WB、IHC(P)和ELISA实验
  • 关于如何获取Tau (Tau-13): sc-21796的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Tau 抗体 (Tau-13) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Tau 抗体 (Tau-13) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

Tau抗体（Tau-13）是一种小鼠单克隆IgG1 kappa轻链抗体，专门用于识别人类重组Tau蛋白。抗Tau抗体（Tau-13）可检测小鼠、大鼠和人类的所有Tau同种型，适用于蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）等应用。Tau，也称为MAPT（微管相关蛋白Tau）或TAU，是一种由758个氨基酸组成的蛋白质，对神经细胞中微管的稳定和组装至关重要。Tau主要位于细胞质、细胞骨架和细胞膜中，含有四个Tau/MAP重复序列，有助于与微管结合，从而维持神经元的极性并支持细胞骨架的可塑性。Tau主要在神经组织中表达，存在多种可变剪接的同工型，对于细胞骨架的动态重组至关重要，而细胞骨架对于神经元的正常功能必不可少。Tau经历多种翻译后修饰，包括磷酸化、多泛素化和糖化，这些修饰可调节其活性和降解过程。Tau基因的失调或突变与多种神经退行性疾病有关，如阿尔茨海默氏症、苍白球-桥脑-黑质变性（PPND）、皮质基底变性（CBD）和进行性核上性麻痹（PSP），这凸显了Tau在神经元健康中的关键作用。Tau 单克隆抗体（Tau-13）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和各种 Alexa Fluor® 结合物，为研究人员提供了灵活多样的实验设置选择。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Tau 抗体 (Tau-13) 参考文献:

  1. Tau 纤维化。  |  Chaudhary, N. and Nagaraj, R. 2012. Subcell Biochem. 65: 75-90. PMID: 23225000
  2. 人类微管相关蛋白tau的多种同种型：阿尔茨海默病神经纤维缠结中的序列和定位。  |  Goedert, M., et al. 1989. Neuron. 3: 519-26. PMID: 2484340
  3. 微管相关蛋白tau磷酸化在阿尔茨海默病中的作用。  |  Ma, RH., et al. 2017. J Huazhong Univ Sci Technolog Med Sci. 37: 307-312. PMID: 28585125
  4. Tau的突触定位。  |  Hanger, DP., et al. 2019. Adv Exp Med Biol. 1184: 105-112. PMID: 32096032
  5. Tau在突触后中的作用。  |  Regan, P. and Cho, K. 2019. Adv Exp Med Biol. 1184: 113-121. PMID: 32096033
  6. Tau寡聚体。  |  Maeda, S. and Takashima, A. 2019. Adv Exp Med Biol. 1184: 373-380. PMID: 32096050
  7. Tau内化：Tau传播中的一个复杂步骤。  |  Zhao, J., et al. 2021. Ageing Res Rev. 67: 101272. PMID: 33571704
  8. Tau聚集在清除和传输之间的命运。  |  Seitkazina, A., et al. 2022. Front Aging Neurosci. 14: 932541. PMID: 35923541
  9. Tau：不仅仅是神经元中的微管结合蛋白。  |  Alonso, ADC., et al. 2024. Cytoskeleton (Hoboken). 81: 71-77. PMID: 37819542
  10. Tau的核面：神经退行性疾病的内部参与者。  |  Younas, N., et al. 2023. Acta Neuropathol Commun. 11: 196. PMID: 38087392

订购信息

产品名称产品编号规格价格数量收藏夹

Tau 抗体 (Tau-13)

sc-21796
200 µg/ml
RMB2377.00

Tau (Tau-13): m-IgG Fc BP-HRP 套装

sc-528371
200 µg Ab; 10 µg BP
RMB2662.00

Tau (Tau-13): m-IgGκ BP-HRP 套装

sc-520733
200 µg Ab, 40 µg BP
RMB2662.00

Tau (Tau-13): m-IgG1 BP-HRP 套装

sc-542899
200 µg Ab; 20 µg BP
RMB2662.00

Tau 抗体 (Tau-13) AC

sc-21796 AC
500 µg/ml, 25% agarose
RMB3129.00

Tau 抗体 (Tau-13) HRP

sc-21796 HRP
200 µg/ml
RMB2377.00

Tau 抗体 (Tau-13) FITC

sc-21796 FITC
200 µg/ml
RMB2482.00

Tau 抗体 (Tau-13) PE

sc-21796 PE
200 µg/ml
RMB2580.00

Tau 抗体 (Tau-13) Alexa Fluor® 488

sc-21796 AF488
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) Alexa Fluor® 546

sc-21796 AF546
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) Alexa Fluor® 594

sc-21796 AF594
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) Alexa Fluor® 647

sc-21796 AF647
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) Alexa Fluor® 680

sc-21796 AF680
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) Alexa Fluor® 790

sc-21796 AF790
200 µg/ml
RMB2685.00

Tau 抗体 (Tau-13) B

sc-21796 B
200 µg/ml
RMB2407.00

To whom concerned, Could you tell me the epitope of anti-Tau (Tau13) (product number: sc-21796)? In another company info, clone tau-13 has the epitope of 15-25 of N-terminal portion of full-length total Tau. The same clone? Thanks!

Asked by: HiroHiroHiro
Thank you for your question. We have not yet further identified its specific epitope.It would be helpful if you could email our Asia Service department at [email protected] for more interactive discussions on this and other related issues.
Answered by: Zhanglong
Date published: 2025-02-24

Good morning, I would like to know which tau epitopes the antibody Tau 13 binds. Thanks

Asked by: MariaCT
Thank you for your question. This antibody was raised against recombinant Tau of human origin and is reactive with all Tau isoforms.
Answered by: Tech Service
Date published: 2019-06-05

Can you provide the epitope sequence or information? Need to make sure this clone (Tau-13) is targeting all human isoforms. Thank you very much!

Asked by: CSYang
Thank you for your question. Unfortunately this antibody has not been epitope mapped, so we do not have further information than what is provided on this product block. It is known to detect all Tau isoforms.
Answered by: Technical Support
Date published: 2019-01-26

Is it possible to buy the hybridoma cell line / vector for transient expression? How much would this cost?

Asked by: Wimq
Thank you for your question. Our hybridoma cell lines are not commercially available for purchase. Please contact our Special Orders Department to inquire about other options, including a bulk purchase of the antibody. Please call us toll-free at (800) 457-3801 option 2, or e-mail <[email protected]>.
Answered by: Technical Support
Date published: 2017-07-31

Is Tau Antibody (Tau-13): sc-21796 available directly conjugated to HRP or fluorescent dyes?

Asked by: jenni
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at [email protected] Alternatively, consider using Tau (Tau 46), which is available conjugated to agarose, HRP, FITC, PE, and more. (https://www.scbt.com/scbt/product/tau-antibody-tau-46)
Answered by: Technical Support 6
Date published: 2017-01-09
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Rated 5 out of 5 by from 很好用，功能很准确用来做WB，结果很好，显示也十分清晰。 性价比很好，沟通过程也比较爽快，货期也比较短。 期待下次的合作愉快。
Date published: 2024-09-02
Rated 5 out of 5 by from Anti-Tau Antibody (Tau-13) is a good Tau antibodyWorks well in our ELISA assay as one of the best pair standing out
Date published: 2022-08-10
Rated 3 out of 5 by from Good antibodyI have used this antibody for IF. The samples were fixed with MeOHl for 5 minutes at -20°C. After blocking solution, I have used the diluited antibody (1:300) for 1h at 37°C. Strong, clear signal with little background.
Date published: 2019-12-02
Rated 5 out of 5 by from Excellent antibody for a very famous protein!This anti-tau antibody is highly specific and identified multiple bands at around 55kda which is perfect. Both human Hek293 and HepG2 cells lines showed the expression of Tau protein based on this antibody and that matched expression pattern reported in human protein atlas. Tau is heavily phosphorylated and there are other post-transnational modifications reported in the literature.The extra high molecular weight bands may be due to multiple differential PTMs. Excellent choice and highly recommend this antibody for your research.
Date published: 2017-11-14
Rated 4 out of 5 by from works well in SH-5Y5Y cellsAble to get similar bands as shown in the product sheet.
Date published: 2017-09-04
Rated 5 out of 5 by from Wow !! Superb IHC and IFTake a look at both IHC and IF staining; forget discontinued polyclonals
Date published: 2017-01-10
Rated 5 out of 5 by from Reliable Antibody for Many ApplicationsThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC. Detects both the regular and phosphorylated version of Tau. Strong, clear signal with little to no background. Works well in a variety of species including mouse, rat, and human samples.
Date published: 2016-12-22
Rated 4 out of 5 by from Robust immunoperoxidase cytoplasmic and membraneRobust immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human breast tissue. -SCBT QC
Date published: 2015-02-12
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Tau抗体 (Tau-13) is rated 4.4 out of 5 by 10.
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