Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

SUZ12 抗体 (D-10): sc-271325

4.9(8)
寫評論提問

说明书
  • SUZ12 抗体 D-10 是小鼠单克隆 IgG1 κ,SUZ12抗体, 在17篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列440-739位于human物种的SUZ12的C-terminus
  • SUZ12 抗体 (D-10) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 SUZ12
  • 抗SUZ12抗体(D-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取SUZ12 (D-10): sc-271325免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是SUZ12 Antibody (D-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与SUZ12 Antibody (D-10) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

SUZ12抗体(D-10)是一种IgG1 κ小鼠单克隆SUZ12抗体(也称为SUZ12 Polycomb抑制复合体2亚基抗体、CHET9抗体、JJAZ1抗体、染色质沉淀E2F靶标9蛋白抗体、与JAZF1蛋白连接的抗体、Polycomb蛋白SUZ12抗体、ChET 9蛋白抗体、Zeste 12同源抑制物(果蝇)抗体或IMMAS抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的SUZ12蛋白。SUZ12抗体(D-10)既有非偶联抗SUZ12抗体形式,也有多种偶联形式的抗SUZ12抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Polycomb群(PcG)基因有助于维持细胞身份、细胞周期调节和肿瘤发生。哺乳动物PcG蛋白是对于Hox基因表达、轴骨发育以及造血细胞增殖和存活控制重要的调节蛋白。通过诱导染色质结构的变化,PcG蛋白成为细胞记忆系统的一部分,该系统负责将基因活性遗传给后代细胞。PcG蛋白通过与不同成分形成多聚蛋白复合物来沉默基因表达。在哺乳动物细胞系中操纵各种PcG蛋白的表达水平会导致细胞转化,这可能是与染色质相关的PcG蛋白与癌症之间的联系。Polycomb蛋白SUZ12,也称为ChET 9蛋白或与JAZF1连接的蛋白,是一种属于VEFS(VRN2-EMF2-FIS2-SUZ12)家族的核蛋白。在已报道的子宫内膜间质肉瘤中,已在某些复发性染色体易位的断点处检测到SUZ12。它是PRC2复合物的组成部分,由EED、EZH2、SUZ12/JJAZ1、RBBP4和RBBP7组成。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SUZ12 抗体 (D-10) 参考文献:

  1. 子宫内膜间质瘤中JAZF1和JJAZ1基因的频繁融合。  |  Koontz, JI., et al. 2001. Proc Natl Acad Sci U S A. 98: 6348-53. PMID: 11371647
  2. 利用染色质免疫沉淀技术克隆新型 E2F 靶启动子。  |  Weinmann, AS., et al. 2001. Mol Cell Biol. 21: 6820-32. PMID: 11564866
  3. 组蛋白 H3 赖氨酸 27 甲基化在多聚酶群沉默中的作用  |  Cao, R., et al. 2002. Science. 298: 1039-43. PMID: 12351676
  4. 组蛋白甲基转移酶活性与含有泽斯特增强子蛋白的人类多蛋白复合物缔合作用。  |  Kuzmichev, A., et al. 2002. Genes Dev. 16: 2893-905. PMID: 12435631
  5. 组蛋白甲基转移酶活性和 EED-EZH2 复合物的沉默功能都需要 SUZ12。  |  Cao, R. and Zhang, Y. 2004. Mol Cell. 15: 57-67. PMID: 15225548
  6. 人类多聚酶靶基因的沉默与组蛋白 H3 Lys 27 的甲基化有关。  |  Kirmizis, A., et al. 2004. Genes Dev. 18: 1592-605. PMID: 15231737
  7. Suz12对小鼠的发育和EZH2组蛋白甲基转移酶的活性至关重要。  |  Pasini, D., et al. 2004. EMBO J. 23: 4061-71. PMID: 15385962

订购信息

产品名称产品编号规格价格数量收藏夹

SUZ12 抗体 (D-10)

sc-271325
200 µg/ml
$316.00

SUZ12 (D-10): m-IgG Fc BP-HRP 套装

sc-529163
200 µg Ab; 10 µg BP
$354.00

SUZ12 (D-10): m-IgGκ BP-HRP 套装

sc-521910
200 µg Ab, 40 µg BP
$354.00

SUZ12 (D-10): m-IgG1 BP-HRP 套装

sc-543362
200 µg Ab; 20 µg BP
$354.00

SUZ12 抗体 (D-10) AC

sc-271325 AC
500 µg/ml, 25% agarose
$416.00

SUZ12 抗体 (D-10) HRP

sc-271325 HRP
200 µg/ml
$316.00

SUZ12 抗体 (D-10) FITC

sc-271325 FITC
200 µg/ml
$330.00

SUZ12 抗体 (D-10) PE

sc-271325 PE
200 µg/ml
$343.00

SUZ12 抗体 (D-10) Alexa Fluor® 488

sc-271325 AF488
200 µg/ml
$357.00

SUZ12 抗体 (D-10) Alexa Fluor® 546

sc-271325 AF546
200 µg/ml
$357.00

SUZ12 抗体 (D-10) Alexa Fluor® 594

sc-271325 AF594
200 µg/ml
$357.00

SUZ12 抗体 (D-10) Alexa Fluor® 647

sc-271325 AF647
200 µg/ml
$357.00

SUZ12 抗体 (D-10) Alexa Fluor® 680

sc-271325 AF680
200 µg/ml
$357.00

SUZ12 抗体 (D-10) Alexa Fluor® 790

sc-271325 AF790
200 µg/ml
$357.00

Hi! I would like to request a free sample of SUZ12 (D-10): sc-271325. Please let me know how to obtain such a sample. Thanks! -Tad

Asked by: Tadeusz
Thank you for your question. Please contact Technical Service for more information on how to receive a 10 μg sample of our well characterized monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-05

What is your recommended western blotting secondary antibody for use with SUZ12 (D-10): sc-271325?

Asked by: jenniferc
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 14
Date published: 2017-02-04
  • y_2025, m_9, d_6, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_271325, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 106ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Western Blot and ImmunocytochemistryThe antibody stains cell nucleus specifically. However, for western blot several non-specific bands were detected. Highly recommended for fluorescence staining.
Date published: 2018-03-07
Rated 5 out of 5 by from good antibody with clear and specific bindgood antibody with clear and specific bind,excelent performence in chip experiment
Date published: 2017-12-19
Rated 5 out of 5 by from Worked great in WesternUsed in 1:400 for western blot of 293T total lysates. Yielded decent staining at expected size.
Date published: 2017-04-28
Rated 5 out of 5 by from worked finefirst try - worked fine! the antibody detects a higher molecular weight though,
Date published: 2017-02-11
Rated 5 out of 5 by from Good functionThis antibody is a very good product and it is enough for an excellent Western Blot signal.
Date published: 2017-02-11
Rated 5 out of 5 by from Very popular choice for WB and IPSUZ12 Antibody (D-10) is a very popular choice for use in Western blotting and immunoprecipitation applications. It is featured in 6 recent journal articles which can be viewed in the product citations list.
Date published: 2017-01-19
Rated 5 out of 5 by from Clean and strong band detected at expectedClean and strong band detected at expected molecular weight in HeLa whole cell lysate. -SCBT QC
Date published: 2015-04-27
Rated 5 out of 5 by from CoIPCoIP, WB publishable data with human transfected 293T cells - SCBT Publication Review
Date published: 2014-06-10
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_8
  • loc_zh_CN, sid_271325, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 18ms
  • REVIEWS, PRODUCT
SUZ12 抗体 (D-10) is rated 4.9 out of 5 by 8.
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_8
  • loc_zh_CN, sid_271325, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 116ms
  • REVIEWS, PRODUCT