Date published: 2026-10-24

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survivin Antibody (C-6) - Western Blotting - Image 351321
survivin 抗体 (C-6): sc-374616. Jurkat (A), IMR-32 (B) 和 A-431 (C) 全细胞裂解液中存活素表达的 Western 印迹分析.
survivin 抗体 (C-6): sc-374616. Jurkat (A), IMR-32 (B) 和 A-431 (C) 全细胞裂解液中存活素表达的 Western 印迹分析.

survivin 抗体 (C-6): sc-374616

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说明书
  • survivin抗体(C-6)是小鼠单克隆IgG1 κ, 在7篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的survivin的N-terminus的氨基酸2-29之间
  • 推荐用于 human 来源的survivin WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 survivin (D-8): sc-17779，可查看有标记的 survivin 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是survivin Antibody (C-6) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与survivin Antibody (C-6) 打包提供（请参阅下面的订购信息）。
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杆状病毒蛋白p35抑制由病毒引起的无脊椎动物和哺乳动物细胞的凋亡，并且可能起损害由宿主免疫系统清除病毒感染细胞的作用。这至少部分地通过p35抑制ICE丝氨酸蛋白酶家族的能力来实现，从而阻断TNF和FAS介导的凋亡。杆状病毒p35的两个哺乳动物同源物，被称为凋亡抑制蛋白（IAP）1和2，共享一个氨基末端杆状病毒IAP重复（BIR）基序和一个羧基末端RING指。尽管c-IAPs不直接与TNF受体（TNF-R）相关，但它们通过与下游TNF-R效应物TRAF1和TRAF2的相互作用，有效地阻断TNF介导的凋亡。IAP家族的其他成员包括ILP（用于IAP样蛋白）和survivin。ILP抑制活化的caspase-3，导致对FAS介导的凋亡的抗性。Survivin（也称为TIAP）在细胞周期的G2/M期表达，并与有丝分裂纺锤体的微管相关。当survivin-微管相互作用发生破坏时，检测到caspase-3活性增加。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

survivin 抗体 (C-6) 参考文献:

  1. 存活素介导肾近曲小管从AKI中恢复  |  Chen, J., et al. 2013. J Am Soc Nephrol. 24: 2023-33. PMID: 23949800
  2. Survivin诱导的异常倍体导致囊性肾和动脉瘤的形成。  |  Aboualaiwi, WA., et al. 2014. Circulation. 129: 660-72. PMID: 24235270
  3. 评估垂体肿瘤中Survivin剪接变体的存在。  |  Waligórska-Stachura, J., et al. 2015. Pituitary. 18: 410-6. PMID: 25107550
  4. 健康和哮喘妊娠中循环survivin水平。  |  Bikov, A., et al. 2014. Reprod Biol Endocrinol. 12: 93. PMID: 25248821
  5. 抑制 MGMT 可抑制胰腺癌中存活素的表达。  |  Bobustuc, GC., et al. 2015. Pancreas. 44: 626-35. PMID: 25875800
  6. 用于小鼠胰腺肿瘤成像的存活素靶向纳米粒子  |  Wang, Z., et al. 2016. Nanomedicine. 12: 1651-61. PMID: 26995092
  7. Survivin在子宫内膜异位症发病机理中的作用。  |  Bianco, B., et al. 2020. Minerva Med. 111: 21-32. PMID: 31755675
  8. 靶向存活素能使宫颈癌细胞对放射治疗敏感。  |  Zhou, J., et al. 2020. Bioengineered. 11: 130-140. PMID: 31959045
  9. 磷酸化调节白塞氏病中 Survivin 的功能  |  Pahlavan, Y., et al. 2020. Adv Pharm Bull. 10: 278-283. PMID: 32373497
  10. 存活素介导缺血性中风新生血管形成的机制  |  Shu, L., et al. 2024. Asian J Surg. 47: 3674-3675. PMID: 38653701

订购信息

产品名称产品编号规格价格数量收藏夹

survivin 抗体 (C-6)

sc-374616
200 µg/ml
CNY2422.00

survivin (C-6): m-IgG Fc BP-HRP 套装

sc-540487
200 µg Ab; 10 µg BP
CNY2715.00

survivin (C-6): m-IgG1 BP-HRP 套装

sc-542154
200 µg Ab; 20 µg BP
CNY2715.00

survivin (C-6) 中和勝肽

sc-374616 P
100 µg/0.5 ml
CNY519.00

Is this antibody available directly conjugated to HRP or fluorescent dyes?

Asked by: cjMara
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at [email protected] Alternatively, consider using survivin (D-8): sc-17779 for survivin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488 and Alexa Fluor® 647.
Answered by: Technical Support 7
Date published: 2017-01-18
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Rated 5 out of 5 by Bill28 from OutstandingVery nice western blot data; strong signal; also great IHC staining
Date published: 2017-02-01
Rated 5 out of 5 by jerojero from Works Great!This antibody works great in western blot analysis of survivin expression in HL-60 (A) and HeLa (B) whole cell lysates.
Date published: 2016-12-23
Rated 5 out of 5 by Wang from Great antibodyGreat antibody. Used it on Human cell samples in Western.
Date published: 2015-10-05
Rated 5 out of 5 by HC from Produced positive Western Blot data of survivinProduced positive Western Blot data of survivin expression in HCT 116 whole cell lysate. -SCBT QC
Date published: 2015-02-12
Rated 5 out of 5 by MC from Produced positive Western Blot data of survivinProduced positive Western Blot data of survivin expression in HL-60 and HeLa whole cell lysates. -SCBT QC
Date published: 2013-11-12
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survivin 抗体 (C-6) is rated 5.0 out of 5 by 5.
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