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Sulfiredoxin 抗体 (B-10): sc-166786

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说明书
  • Sulfiredoxin抗体(B-10)是小鼠单克隆IgG2a κ, 在3篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Sulfiredoxin的C-terminus的氨基酸121-137之间
  • 推荐用于 mouse, rat 和 human 来源的Sulfiredoxin WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine and porcine
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是Sulfiredoxin Antibody (B-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Sulfiredoxin Antibody (B-10) 打包提供(请参阅下面的订购信息)。

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関連項目

Sulfiredoxin,也称为Sulfiredoxin-1和染色体20开放阅读框139(C20orf139),是一种细胞质抗氧化蛋白,通过催化减少氧化修饰参与信号传导。它通过将保守的半胱氨酸从亚磺酸还原为亚磺酸来调节过氧化物酶(PRXs),这是一类减少过氧化氢的蛋白质家族。这影响了PRX在其他下游转录因子和激酶信号通路中的作用。Sulfiredoxin蛋白特异性地作用于PRDX1、PRDX2、PRDX3和PRDX4过氧化物酶,但不作用于PRDX5或PRDX6。Sulfiredoxin作为磷酸转移酶和硫醇转移酶起作用,并且在体内广泛表达,在肺、脾、肾和胸腺组织中检测到最高水平。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Sulfiredoxin 抗体 (B-10) 参考文献:

  1. 硫亚磺酸酯中间体与过氧化还原酶在催化机制中形成共价硫亚磺酸酯中间体的证据。  |  Roussel, X., et al. 2008. J Biol Chem. 283: 22371-82. PMID: 18552404
  2. c-Jun依赖性硫氧还蛋白诱导介导BDNF保护大鼠皮质神经元免受线粒体抑制。  |  Wu, CL., et al. 2012. Neurobiol Dis. 46: 450-62. PMID: 22402332
  3. 硫氧还蛋白-1可保护原代培养的星形胶质细胞免受缺血损伤。  |  Yu, S., et al. 2015. Neurochem Int. 82: 19-27. PMID: 25620665
  4. 线粒体H2O2信号传导受过氧化物还原酶III和硫氧还蛋白的共同作用控制:将线粒体功能与昼夜节律联系起来。  |  Rhee, SG. and Kil, IS. 2016. Free Radic Biol Med. 100: 73-80. PMID: 28236420
  5. 硫亚磺酸酯-1是肝细胞癌的一种有前景的新型预后生物标志物。  |  Rao, QW., et al. 2020. Cancer Med. 9: 8318-8332. PMID: 32955798
  6. 人类硫氧还蛋白还原剂和过氧化物酶同工型的特异性。  |  Forshaw, TE., et al. 2021. Antioxidants (Basel). 10: PMID: 34208049
  7. 硫亚磺酸酯-过氧化还原酶氧化还原系统调节结肠癌干细胞的干细胞和存活。  |  Song, IS., et al. 2021. Redox Biol. 48: 102190. PMID: 34798428
  8. 硫氧还蛋白-1的血液mRNA表达水平与海马萎缩和认知能力下降呈负相关。  |  Cucos, CA., et al. 2022. F1000Res. 11: 114. PMID: 35242306
  9. 揭示硫氧还蛋白-1在早发型子痫前期中的作用:滋养层细胞铁死亡的关键参与者。  |  Wei, J., et al. 2024. J Reprod Immunol. 164: 104273. PMID: 38852489
  10. 硫氧还蛋白-1通过抑制TFEB介导的细胞自噬和溶酶体生物发生促进肝细胞癌的生长。  |  Rao, Q., et al. 2024. Exp Cell Res. 441: 114169. PMID: 39029574

订购信息

产品名称产品编号规格价格数量收藏夹

Sulfiredoxin 抗体 (B-10)

sc-166786
200 µg/ml
RMB2377.00

Sulfiredoxin (B-10): m-IgG Fc BP-HRP 套装

sc-537530
200 µg Ab; 10 µg BP
RMB2662.00

Sulfiredoxin (B-10): m-IgGκ BP-HRP 套装

sc-534823
200 µg Ab; 40 µg BP
RMB2662.00

Sulfiredoxin (B-10): m-IgG2a BP-HRP 套装

sc-548045
200 µg Ab; 10 µg BP
RMB2662.00

Sulfiredoxin (B-10) 中和勝肽

sc-166786 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-166786 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from Not good for probing rat endogenous proteinI used rat cell lysate with this antibody to test endogenous SRNX-1, tried 10ug, 20ug and 30ug loading, tried 1;1000, 1:500. 1:250, 1:125 and 1:50. All those combinations give me a band around 37 kD, no 14 kD band detected.
Date published: 2016-12-22
Rated 5 out of 5 by from Good Western Blot data of Sulfiredoxin expressionGood Western Blot data of Sulfiredoxin expression in non-transfected and human Sulfiredoxin transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-04-27
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Sulfiredoxin 抗体 (B-10) is rated 3.0 out of 5 by 2.
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