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Substance P 抗体 (SP-DE4-21): sc-58591

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说明书
  • Substance P 抗体 SP-DE4-21 是小鼠单克隆 IgG1, 在16篇文献中引用,提供 50 µg/500 µl
  • 免疫human物种的Substance P的氨基酸1-11
  • 推荐用于 mouse, rat 和 human 来源的Substance P and protachykinin 1 precursor IF 和 IHC(P)检测; 也和以下物种反应,包括: 和 equine and bovine; 不会与 related Tachykinins (human Neurokinin A, Neurokinin B, and Kassinin)产生交联反应
  • 目前,我们还没有完成Substance P 抗体 (SP-DE4-21)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

物质 P 抗体(SP-DE4-21)是一种小鼠单克隆 IgG1 抗体,专门设计用于靶向物质 P,这是一种 11 氨基酸的神经肽,属于速激肽家族,也称为神经激肽-1 配体。物质 P 的结构至关重要,因为其精确的氨基酸排列使其能够有效地与神经激肽-1(NK1)受体结合,从而介导疼痛传导、炎症和血管扩张等重要生理过程。当用于免疫荧光(IF)和石蜡包埋切片免疫组化(IHCP)时,抗物质 P 抗体(SP-DE4-21)可与小鼠、大鼠、人、马和牛体内的物质 P 和原速激肽 1 前体发生反应,并且不会与相关的速激肽(如神经激肽 A、神经激肽 B 或卡西蛋白)发生交叉反应。物质 P 单克隆抗体(SP-DE4-21)有助于研究人员探索该肽在神经和免疫功能中的作用,有助于疼痛机制和炎症性疾病的研究。了解物质 P 的结构非常重要,因为任何改变都会影响它与受体的相互作用,从而影响其生物活性和作为治疗靶点的潜力。抗物质 P 抗体 (SP-DE4-21) 是研究涉及速激肽的复杂途径及其对健康和疾病的影响的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Substance P 抗体 (SP-DE4-21) 参考文献:

  1. 激肽和激肽受体:结构和活性关系。  |  Coveñas, R. and Muñoz, M. 2014. Histol Histopathol. 29: 881-90. PMID: 24535838
  2. 炎症性疼痛中激肽神经免疫连接。  |  Bignami, F., et al. 2016. Curr Drug Targets. 17: 1265-74. PMID: 26477461
  3. 肠道中的激肽受体:生理和病理意义。  |  Mistrova, E., et al. 2016. Neuropeptides. 58: 41-51. PMID: 26706184
  4. 神经肽物质 P 与免疫反应。  |  Mashaghi, A., et al. 2016. Cell Mol Life Sci. 73: 4249-4264. PMID: 27314883
  5. 癌症进展与物质P。  |  Chi, G., et al. 2018. Curr Neuropharmacol. 16: 43-50. PMID: 28474564
  6. 激肽和激肽受体:一个不断发展的家族。  |  Seo, EJ., et al. 2018. Life Sci. 203: 268-275. PMID: 29730167
  7. 物质P及其对眼部炎症的抑制作用。  |  Zieglgänsberger, W. 2019. Cell Tissue Res. 375: 227-241. PMID: 30284083
  8. 多巴胺、5-羟色胺和激肽在自残行为中的作用。  |  Feickert, M. and Burckhardt, BB. 2019. Clin Chim Acta. 495: 501-506. PMID: 31103623
  9. 物质P与纤维化疾病。  |  Peng, L., et al. 2019. Neuropeptides. 76: 101941. PMID: 31256921
  10. 物质P可阻断乙醇引起的肝毒性。  |  Redkiewicz, P. 2022. Int J Mol Sci. 23: PMID: 35054936

订购信息

产品名称产品编号规格价格数量收藏夹

Substance P 抗体 (SP-DE4-21)

sc-58591
50 µg/500 µl
CNY2422.00

Can Substance P Antibody (SP-DE4-21): sc-58591 be used for WB?

Asked by: Heine
Thank you for your question. We do not currently recommend this antibody for use in a Western blotting application (WB). However, there are a couple of product citations that mention using this antibody for WB. Please refer to the following papers as a reference: PMID’s: 26951962 and 29089453.
Answered by: Technical Support
Date published: 2018-12-21

Can sc-58591: Substance P (SP-DE4-21) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jenniferc
Thank you for your question. Yes, sc-58591: Substance P (SP-DE4-21) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by Albson from worked excellent1:100 dilution used with paraffin embedded , It is highly suitable to show cellular staining.
Date published: 2017-04-13
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Substance P 抗体 (SP-DE4-21) is rated 4.5 out of 5 by 2.
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