Date published: 2025-9-8

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Spastin 抗体 (Sp 6C6): sc-81624

3.5(2)
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说明书
  • Spastin抗体(Sp 6C6)是小鼠单克隆IgG2a κ, 在4篇文献中引用,规格为200 µg/ml
  • 免疫human物种的重组Spastin
  • 推荐用于 mouse, rat 和 human 来源的Spastin WB, IP 和 IF检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是Spastin Antibody (Sp 6C6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Spastin Antibody (Sp 6C6) 打包提供(请参阅下面的订购信息)。

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AAA蛋白家族成员共享一个ATP酶结构域,并在各种细胞过程中发挥作用,包括细胞内运动、膜转运、蛋白质水解、蛋白质折叠和细胞器生物发生。Spastin是AAA蛋白家族的一个成员,是一种由616个氨基酸组成的蛋白质,参与核蛋白复合物的功能或组装。Spastin蛋白在细胞中普遍表达,定位于细胞核和细胞质,也可能参与微管动力学。Spastin基因(SPAST,SPG4)的突变导致最常见的痉挛性截瘫4型,这是一种常染色体显性遗传性痉挛性截瘫(HSP)。HSPs是一组遗传性神经障碍,其特征是由于皮质脊髓运动神经元的长度依赖性逆行性轴突病变导致的下肢痉挛性无力。SPAST特异性突变约占所有常染色体显性HSPs的40%。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Spastin 抗体 (Sp 6C6) 参考文献:

  1. Spastin和微管:在健康和疾病中的功能  |  Salinas, S., et al. 2007. J Neurosci Res. 85: 2778-82. PMID: 17348041
  2. AAA ATPase spastin 将微管切断与膜建模联系在一起。  |  Lumb, JH., et al. 2012. Biochim Biophys Acta. 1823: 192-7. PMID: 21888932
  3. Spastin与CRMP5相互作用,通过控制微管动力学促进神经元外生  |  Ji, Z., et al. 2018. Dev Neurobiol. 78: 1191-1205. PMID: 30257070
  4. 通过防止内切酶依赖性降解,使遗传性痉挛性截瘫患者的 Spastin 恢复正常。  |  Sardina, F., et al. 2020. Life Sci Alliance. 3: PMID: 33106322
  5. Spastin与CRMP5相互作用,通过切断微管促进小鼠卵母细胞中纺锤体的组织。  |  Jin, Z., et al. 2022. Zygote. 30: 80-91. PMID: 34034836
  6. Rab3A 与 spastin 相互作用,调控海马神经元的神经元突起。  |  Yang, Y., et al. 2023. Biochem Biophys Res Commun. 643: 77-87. PMID: 36587525
  7. 抑制脊蛋白会影响脊髓损伤后的运动功能恢复。  |  Yang, J., et al. 2023. Brain Res Bull. 205: 110806. PMID: 37918696
  8. Spastin调节无丝分裂期染色体分离距离和含微管的核隧道。  |  Kelley, ME., et al. 2024. Mol Biol Cell. 35: ar48. PMID: 38335450
  9. Spastin 可在局部放大微管动力学,为突触前的货物运输提供轴突模式。  |  Aiken, J. and Holzbaur, ELF. 2024. Curr Biol. 34: 1687-1704.e8. PMID: 38554708
  10. Spastin调节ER-线粒体接触点和线粒体的稳态。  |  Raby, A., et al. 2024. iScience. 27: 110683. PMID: 39252960

订购信息

产品名称产品编号规格价格数量收藏夹

Spastin 抗体 (Sp 6C6)

sc-81624
200 µg/ml
RMB2377.00

Spastin (Sp 6C6): m-IgG Fc BP-HRP 套装

sc-537251
200 µg Ab; 10 µg BP
RMB2662.00

Spastin (Sp 6C6): m-IgGκ BP-HRP 套装

sc-534476
200 µg Ab; 40 µg BP
RMB2662.00

Spastin (Sp 6C6): m-IgG2a BP-HRP 套装

sc-547948
200 µg Ab; 10 µg BP
RMB2662.00

Could you provide the targeting site of Spastin Antibody (Sp 6C6): sc-81624 ?

Asked by: Cho Ming
Thank you for your question. No epitope mapping has been performed for this antibody yet. Its exact epitope on its target protein is unknown.
Answered by: Technical Support Europe
Date published: 2020-10-11

Are there any issues with using sc-81624: Spastin (Sp 6C6) mouse monoclonal primary antibody on mouse samples?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-81624 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Has been working really well in WBHas been working really well in WB!
Date published: 2015-07-23
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Spastin 抗体 (Sp 6C6) is rated 3.5 out of 5 by 2.
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