Date published: 2026-10-24

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Superoxide Dismutase 2/SOD2 Antibody (E-10) - Western Blotting - Image 366655
SOD-2 抗体 (E-10): sc-137254 HRP. 非转染 293: sc-110760 (A), 人 SOD-2 转染 293: sc-113078 (B) 和 U-87 MG (C) 全细胞裂解液以及大鼠肝脏 (D), 人肝脏 (E) 和小鼠肝脏 (F) 组织提取物中 SOD-2 表达的直接 Western 印迹分析.
SOD-2 抗体 (E-10): sc-137254 HRP. 非转染 293: sc-110760 (A), 人 SOD-2 转染 293: sc-113078 (B) 和 U-87 MG (C) 全细胞裂解液以及大鼠肝脏 (D), 人肝脏 (E) 和小鼠肝脏 (F) 组织提取物中 SOD-2 表达的直接 Western 印迹分析.

Superoxide Dismutase 2/SOD2 抗体 (E-10): sc-137254

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寫評論提問
说明书
  • Superoxide Dismutase 2/SOD2 抗体 E-10 是小鼠单克隆 IgG2b κ，Superoxide Dismutase 2/SOD2抗体, 在129篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的SOD-2的N-terminus附近的氨基酸22-58之间
  • Superoxide Dismutase 2/SOD2 抗体 (E-10) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 SOD-2; 也和以下物种反应，包括： 和 canine, bovine and porcine
  • 抗Superoxide Dismutase 2/SOD2抗体（E-10）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是Superoxide Dismutase 2/SOD2 Antibody (E-10) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Superoxide Dismutase 2/SOD2 Antibody (E-10) 打包提供（请参阅下面的订购信息）。
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研究信息

関連項目

附加SOD抗体，包括SOD-1, SOD-2和SOD-3

SOD-2抗体（E-10）是一种IgG2b κ小鼠单克隆SOD-2抗体（也称为SOD2抗体、超氧化物歧化酶2抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的SOD-2蛋白。SOD-2抗体（E-10）既有非偶联形式的抗SOD-2抗体，也有多种偶联形式的抗SOD-2抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。超氧化物歧化酶家族由三种金属酶（SOD-1、SOD-2和SOD-3）组成，可催化活性氧（ROS）如超氧阴离子的氧化还原。SOD-2前体是一种由核染色质编码的222个氨基酸的蛋白质，在细胞质中合成，翻译后导入线粒体基质。与作为同源二聚体细胞质Cu-Zn酶的SOD-1不同，SOD-2是一种同源四聚体锰酶（也称为MnSOD），在线粒体中发挥作用。ROS涉及广泛的退行性过程，包括阿尔茨海默病、帕金森病和缺血性心脏病。缺乏SOD-2的纯合突变小鼠表现出扩张型心肌病、肝脏和骨骼肌中脂质积累、代谢性酸中毒、氧化性DNA损伤以及心脏和骨骼肌中呼吸链缺陷。SOD-2基因的多态性也与人类的非家族性、特发性扩张型心肌病有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Superoxide Dismutase 2/SOD2 抗体 (E-10) 参考文献:

  1. 超氧化物歧化酶锰（Sod2）与驱动转移的信号事件的氧化还原控制。  |  Hempel, N., et al. 2011. Anticancer Agents Med Chem. 11: 191-201. PMID: 21434856
  2. SOD-2基因的多态性差异可能影响糖尿病患者和糖尿病并发症患者肾病的发病机制。  |  Houldsworth, A., et al. 2015. Gene. 569: 41-5. PMID: 25858271
  3. SOD2的强表达和HPV-16/18阳性是宫颈癌中的独立事件。  |  Rabelo-Santos, SH., et al. 2018. Oncotarget. 9: 21630-21640. PMID: 29774090
  4. TNF‑α介导的SOD‑2上调可促进食管鳞状细胞癌细胞增殖和顺铂耐药性。  |  Zuo, J., et al. 2019. Oncol Rep. 42: 1497-1506. PMID: 31364751
  5. 骨髓间充质干细胞中SOD2的过度表达可改善肝缺血/再灌注损伤。  |  Li, Q., et al. 2021. Mol Med Rep. 24: PMID: 34296303
  6. PPARγ/SOD2 通过抑制 ATG4D 介导的丝裂促进胰腺癌增殖，从而防止线粒体 ROS 依赖性凋亡  |  Nie, S., et al. 2021. Front Cell Dev Biol. 9: 745554. PMID: 35186942
  7. Maresin 1 通过 LGR6 介导的 cAMP-SOD2-ROS 通路缓解糖尿病肾病  |  Li, X., et al. 2022. Oxid Med Cell Longev. 2022: 7177889. PMID: 35498124
  8. SOD2缺失导致星形胶质细胞氧化还原失衡，加速小鼠衰老。  |  Tsesmelis, K., et al. 2023. Aging Cell. 22: e13911. PMID: 37609868
  9. 靶向ZNF-148/miR-335/SOD2信號級聯可引發氧化應激介導的熱潰瘍，抑制乳腺癌的進展。  |  Wang, Y., et al. 2023. Cancer Med. 12: 21308-21320. PMID: 37909239
  10. 姜黄素通过 SIRT3-SOD2-ROS 信号通路调节自噬，改善 KOA 大鼠模型股四头肌萎缩。  |  Ye, H., et al. 2024. Sci Rep. 14: 8176. PMID: 38589505

订购信息

产品名称产品编号规格价格数量收藏夹

Superoxide Dismutase 2/SOD2 抗体 (E-10)

sc-137254
200 µg/ml
CNY2422.00

Superoxide Dismutase 2/SOD2 (E-10): m-IgGκ BP-HRP 套装

sc-521473
200 µg Ab, 40 µg BP
CNY2715.00

Superoxide Dismutase 2/SOD2 (E-10): m-IgG2b BP-HRP 套装

sc-548909
200 µg Ab; 10 µg BP
CNY2715.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) AC

sc-137254 AC
500 µg/ml, 25% agarose
CNY3189.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) HRP

sc-137254 HRP
200 µg/ml
CNY2422.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) FITC

sc-137254 FITC
200 µg/ml
CNY2527.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) PE

sc-137254 PE
200 µg/ml
CNY2625.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 488

sc-137254 AF488
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 546

sc-137254 AF546
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 594

sc-137254 AF594
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 647

sc-137254 AF647
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 680

sc-137254 AF680
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 抗体 (E-10) Alexa Fluor® 790

sc-137254 AF790
200 µg/ml
CNY2738.00

Superoxide Dismutase 2/SOD2 (E-10) 中和勝肽

sc-137254 P
100 µg/0.5 ml
CNY519.00

Can SOD-2 (E-10): sc-137254 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jenni
Thank you for your question. Yes, SOD-2 (E-10): sc-137254 monoclonal antibody has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support 9
Date published: 2017-01-12

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with SOD-2 (E-10): sc-137254?

Asked by: jenni
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 9
Date published: 2017-01-12
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Rated 4 out of 5 by Morena from Works just fineGreat strong and specific band used in liver samples using 80ug of protein
Date published: 2026-06-02
Rated 4 out of 5 by Manu9 from It works wellWe used this antibody in WB, good signal. 1:500 concentration
Date published: 2023-10-23
Rated 5 out of 5 by Bhava from Anti-SOD2 antibodyMembranes probed with anti-SOD2 antibody to monitor protein expressions by western blot analysis.
Date published: 2023-06-30
Rated 5 out of 5 by 137254 from SOD-2 (E-10)The experiment was completed, the antibody is good, maybe my experimental conditions are not good, the background is a little deep, the overall performance is good.
Date published: 2022-08-14
Rated 5 out of 5 by AgnieszkaBiol from Excellent sensitivityThis antibody detects even very low concentration of SOD2 w lysates of THP1-derived macrophages. Nicely visualizes even small differences in the protein level between samples.
Date published: 2018-12-17
Rated 4 out of 5 by sissi from Good!!This antibody works well in western blot in human pancreatic cancer cells
Date published: 2018-12-05
Rated 4 out of 5 by Priscilabarbosa from Great featuresThis antibody works well in rat liver tissue, but it`s possible to see other band in the top. I don`t know if that happened with someone more. Anyway, my protein of interest can also be seen by a strong signal.
Date published: 2018-03-13
Rated 3 out of 5 by Brígida Pinho from Weak signalWestern-blot: A faint band was obtained with this antibody at 1:500, overnight.
Date published: 2017-12-07
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Superoxide Dismutase 2/SOD2 抗体 (E-10) is rated 4.8 out of 5 by 24.
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